Institution
University Hospital of North Durham
Healthcare•Durham, England, United Kingdom•
About: University Hospital of North Durham is a healthcare organization based out in Durham, England, United Kingdom. It is known for research contribution in the topics: Population & Cancer. The organization has 345 authors who have published 284 publications receiving 4490 citations. The organization is also known as: Dryburn Hospital.
Topics: Population, Cancer, Health care, Knee replacement, Chronic constipation
Papers published on a yearly basis
Papers
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TL;DR: Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries and should also address the need for safe perioperative care.
Abstract: Background
As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care.
Methods
We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries.
Results
A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2–7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries.
Conclusions
Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care.
364 citations
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TL;DR: No evidence was identified that a multistrain preparation of lactobacilli and bifidobacteria was effective in prevention of AAD or CDD, and an improved understanding of the pathophysiology of A AD is needed to guide future studies.
329 citations
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TL;DR: Treatment with a proton pump inhibitor reduces the risk of rebleeding and the requirement for surgery after ulcer bleeding but has no benefit on overall mortality.
Abstract: Objectives To review randomised controlled trials of treatment with a proton pump inhibitor in patients with ulcer bleeding and determine the impact on mortality, rebleeding, and surgical intervention.
Design Systematic review and meta-analysis.
Data sources Cochrane Collaboration's trials register, Medline, and Embase, handsearched abstracts, and pharmaceutical companies.
Review methods Included randomised controlled trials compared proton pump inhibitor with placebo or H2 receptor antagonist in endoscopically proved bleeding ulcer and reported at least one of mortality, rebleeding, or surgical intervention. Trials were graded for methodological quality. Two assessors independently reviewed each trial, and disagreements were resolved by consensus.
Results We included 21 randomised controlled trials comprising 2915 patients. Proton pump inhibitor treatment had no significant effect on mortality (odds ratio 1.11, 95% confidence interval 0.79 to 1.57; number needed to treat (NNT) incalculable) but reduced rebleeding (0.46, 0.33 to 0.64; NNT 12) and surgery (0.59, 0.46 to 0.76; NNT 20). Results were similar when the meta-analysis was restricted to the 10 trials with the highest methodological quality: 0.96, 0.46 to 2.01, for mortality; 0.41, 0.25 to 0.68, NNT 10, for rebleeding; 0.62, 0.46 to 0.83, NNT 25, for surgery.
Conclusions Treatment with a proton pump inhibitor reduces the risk of rebleeding and the requirement for surgery after ulcer bleeding but has no benefit on overall mortality.
154 citations
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King's College London1, University of Zurich2, Beni-Suef University3, University of Szeged4, Trinity College, Dublin5, National Skin Centre6, Tartu University Hospital7, University of Tartu8, University of Kiel9, Royal Victoria Infirmary10, Medical University of Vienna11, University of Washington12, University Hospital of North Durham13, University of Manchester14, University of Bradford15, University of Glasgow16, Monash University Malaysia Campus17
TL;DR: In this paper, the authors sought to characterize the clinical and genetic features of pustular psoriasis through the analysis of an extended patient cohort, including 863 unrelated patients (251 with GPP, 560 with PPP, 28 with acrodermatitis continua of Hallopeau [ACH], and 24 with multiple diagnoses).
Abstract: Background The term pustular psoriasis indicates a group of severe skin disorders characterized by eruptions of neutrophil-filled pustules. The disease, which often manifests with concurrent psoriasis vulgaris, can have an acute systemic (generalized pustular psoriasis [GPP]) or chronic localized (palmoplantar pustulosis [PPP] and acrodermatitis continua of Hallopeau [ACH]) presentation. Although mutations have been uncovered in IL36RN and AP1S3, the rarity of the disease has hindered the study of genotype-phenotype correlations. Objective We sought to characterize the clinical and genetic features of pustular psoriasis through the analysis of an extended patient cohort. Methods We ascertained a data set of unprecedented size, including 863 unrelated patients (251 with GPP, 560 with PPP, 28 with ACH, and 24 with multiple diagnoses). We undertook mutation screening in 473 cases. Results Psoriasis vulgaris concurrence was lowest in PPP (15.8% vs 54.4% in GPP and 46.2% in ACH, P Conclusions The analysis of an unparalleled resource revealed key clinical and genetic differences between patients with PPP and those with GPP.
149 citations
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TL;DR: This review looks into the various modes of presentation, ways to minimise spillage, treating the complications, and the legal implications of laparoscopic cholecystectomy.
Abstract: Laparoscopic cholecystectomy is associated with spillage of gall stones in 5%–40% of procedures, but complications occur very rarely. There are, however, isolated case reports describing a range of complications occurring both at a distance from and near to the subhepatic area. This review looks into the various modes of presentation, ways to minimise spillage, treating the complications, and the legal implications.
130 citations
Authors
Showing all 346 results
Name | H-index | Papers | Citations |
---|---|---|---|
William MacNee | 123 | 472 | 58989 |
Andrew A. Amis | 84 | 360 | 20670 |
Anselm Hennis | 48 | 157 | 18785 |
Simon Maxwell | 39 | 136 | 5277 |
Grigorios I. Leontiadis | 34 | 119 | 5410 |
Simon S. Jameson | 33 | 82 | 4402 |
David J. Langton | 29 | 85 | 4069 |
Yan Yiannakou | 15 | 48 | 620 |
L. Longstaff | 14 | 24 | 807 |
Matthew G.D. Bates | 14 | 38 | 1204 |
Grigoris I. Leontiadis | 11 | 30 | 745 |
Rajive Mathew Jose | 10 | 34 | 381 |
Julie Cox | 9 | 22 | 238 |
Shyamal Wahie | 8 | 14 | 238 |
Kim R Quimby | 7 | 16 | 133 |