Showing papers by "University of Alabama at Birmingham published in 1971"
TL;DR: Left ventricular dimensions in systole and diastole can be reliably determined and left ventricular chamber size and ejection fraction can be quantitated in man by the noninvasive technique of echocardiography.
Abstract: Left ventricular end-diastolic and end-systolic volume, stroke volume, and ejection fraction were determined by biplane angiocardiography and echocardiography in 27 patients suspected of having heart disease. Angiographic volumes were calculated by the area-length method and echocardiographic volumes, from the left ventricular dimension of the echograms. The angiographic minor diameter and the semilength correlated significantly with the echocardiographic left ventricular dimensions in diastole and systole. Left ventricular size over a wide range compared favorably by each technique, with a correlation coefficient of r = 0.97 for end-diastolic volume (range by angiography 80-585 ml, see ± 27.76), r = 0.97 for end-systolic volume (range by angiography 24-485 ml, see ± 23.64), r = 0.83 for total left ventricular stroke volume (range by angiography 35-229 ml, see ± 25.45), and r = 0.80 for left ventricular ejection fraction (range by angiography 0.18-0.70, see ± 0.09). These data indicate that left ventricul...
659 citations
TL;DR: Unique polypeptide chains have been isolated from S-sulfonated light-chain fractions of human serum immunoglobulin M and colostral immunoglOBulin A, which differ from those of light chains and secretory piece.
Abstract: Unique polypeptide chains have been isolated from S-sulfonated light-chain fractions of human serum immunoglobulin M and colostral immunoglobulin A. Their electrophoretic mobilities, molecular weights, peptide maps, amino acid compositions, and antigenic determinants are very similar or perhaps identical but differ from those of light chains and secretory piece.
221 citations
TL;DR: Two females with agammaglobulinaemia had nearly normal numbers of B lymphocytes bearing membrane-bound IgM, IgG, and IgA and formed germinal centres in antigen-stimulated lymph-nodes.
213 citations
TL;DR: A gas chromatographic method for determining the neutral and amino sugars commonly found in glycoproteins of animal origin, which can be determined on as little as 1 mg of a glycoprotein which contains 6% total carbohydrate.
119 citations
TL;DR: F Fluorochrome-labelled antibodies to human amylase, lysozyme and immunoglobulins reveal a different cellular source for each of these proteins in the human parotid gland.
118 citations
TL;DR: A juvenile Siamese cat with severe, progressive motor disability was shown to have extensive neuronal degeneration caused by accumulation of GM1 ganglioside, strikingly similar to juvenile GM1gangliosidosis of children.
Abstract: A juvenile Siamese cat with severe, progressive motor disability was shown to have extensive neuronal degeneration caused by accumulation of GM(1) ganglioside. Tissues from brain and kidney were markedly deficient in beta-galactosidase activity. The disease in this cat is thought to be inherited as an autosomal recessive trait, and is strikingly similar to juvenile GM(1) gangliosidosis of children.
117 citations
TL;DR: In synovial fluid from patients with rheumatoid arthritis, the mean concentrations of copper, iron and zinc were high; aluminum, barium, tin, strontium and cadmium were low; and manganese, nickel, cesium, chromium, lead and molybdenum were normal.
94 citations
TL;DR: Complete amino acid analyses of purified Clq from human serum indicate that this glycoprotein has an unusual composition for a serum protein, which includes hydroxyproline, hydroxylysine and high levels of glycine.
89 citations
TL;DR: The pits and fissures were the major source of Strep.
74 citations
71 citations
TL;DR: Current indications are that the human fetus is not immunologically incompetent, and an elevated IgM level may be a nonspecific indicator of a newborn at high risk for intrauterine infections--which may not be clinically apparent.
TL;DR: A tentative model for the HCO 3 − activation mechanism is suggested after an ATPase has been solubilized from dog gastric mucosa which was localized to the smooth vesicular fraction of the tissue homogenate.
TL;DR: High activity of the ATPase is found in tissues of Necturus which transport H+ and/or C1− and which have a high carbonic anhydrase content and a method is described for solubilization of the enzyme resulting in a marked increase in the sensitivity to HCO3− and SCN−.
TL;DR: In children, the dextranase mouthwash had no demonstrable effect on plaque formation as evidenced by plaque score and dry weight measurements, and in young adults, there was a significant increase in the nitrogen concentration of the plaque during plaque formation.
Abstract: The first article in this three-part feature reports two clinical studies, the first with young adults and the second with children. In young adults, the dextranase had no statistically significant effect on plaque score, dry weight, carbohydrate concentration, percent of the bacteria that were dextranformers, or on differential microscopic counts of plaque bacteria. However, there was a significant increase in the nitrogen concentration of the plaque during plaque formation. In children, the dextranase mouthwash had no demonstrable effect on plaque formation as evidenced by plaque score and dry weight measurements.
TL;DR: A greater number and wider age span of human fetuses were studied to provide a more comprehensive series of photographs showing craniofacial growth changes and the data on movements of the mandible will be correlated with the development of the temporomandibular joint as described in the literature.
Abstract: During a recent investigation to correlate transposition of the palatal shelves in human fetuses with reflexes that include active mouth opening by mandibular depression,' an increase in size of the mandible was noted immediately after the change in position of the palatal shelves and tongue. In that paper,' an explanation was offered for the rapid change in size of the mandible at this period of development. Because these preliminary observations are not entirely in agreement with some of the conclusions in the literature,2 including those based on morphologic cephalometric methods of investigation,3-5 a greater number and wider age span of human fetuses were studied to provide a more comprehensive series of photographs showing craniofacial growth changes. To make correlations between activity in the oral and facial regions and the morphologic changes in these rgions, summaries of the types of orofacial activity will be provided from previous publications.6-'3 Likewise, the data on movements of the mandible will be correlated with the development of the temporomandibular joint as described in the literature.'4
Patent•
22 Apr 1971TL;DR: In this paper, the outer cannula has symmetrically separable components and one end thereof engages a bone in which a hole is drilled, while the inner cannula terminates inwardly of the one end of the outer and a stylus extends to a point adjacent said one end.
Abstract: A surgical instrument for placement of bone pins and holes therefor having an outer cannula telescopically receiving an inner cannula which in turn telescopically receives a stylus. The outer cannula has symmetrically separable components and one end thereof engages a bone in which a hole is drilled. A tool is detachably connected to the outer cannula for retaining the outer cannula assembly. An inner cannula terminates inwardly of said one end of the outer cannula and a stylus extends to a point adjacent said one end of the outer cannula.
TL;DR: Submandibular MED's of four adult rats were investigated by transmission electron microscopy for active transport of Na+ and K+ by the main excretory duct (MED) of the rat sub mandibular gland.
Abstract: Recent data indicate active transport of Na+ and K+ by the main excretory duct (MED) of the rat submandibular gland. In view of these data submandibular MED's of four adult rats were investigated by transmission electron microscopy. Luminal surfaces of two MED's were examined with the scanning electron microscope. The duct is surrounded by connective tissue, blood vessels and neuron perikarya. Blood supply to the ductal epithelium consists of a plexus of sinusoidal capillaries. Three principal cell types compose the epithelium: light cells, dark cells, and basal cells. The basal cells resemble those of striated ducts except for the presence of numerous hemidesmosomes along basal plasma membranes of MED basal cells. Light cells show basal infoldings, and bulbous enlargements may occur at their distal aspects. Dark cells are narrow, electron dense cells with prominent microvilli at the luminal surface. Intercellular clefts penetrate MED epithelium from the lumen to a depth of one-third the epithelial thickness. Surfaces of the clefts are lined by dark and light cells. Intercellular tissue spaces are present at lateral boundaries of all cells and extend from the epithelial base to distal cytoplasmic levels.
TL;DR: Increases of calcium, phosphate and hydroxyl ion concentrations, and addition of 1 ppm fluoride to remineralizing solutions increased the rate of enamel Remineralized enamel was as resistant to dissolution by weak acids as natural mineralization enamel, and enamel remIneralized in solutions containing 1 ppm Fluoride was more resistant than naturally mineralized Enamel.
TL;DR: In this paper, an emission spectrometric method of analysis was described, in which trace quantities of copper, iron, aluminum, barium, manganese, nickel, cesium, tin, strontium, chromium, zinc, lead, molybdenum, and cadmium were determined in blood serum.
Abstract: An emission spectrometric method of analysis is described, in which trace quantities of copper, iron, aluminum, barium, manganese, nickel, cesium, tin, strontium, chromium, zinc, lead, molybdenum, and cadmium were determined in blood serum. The sample preparation, starting with 2.0 ml of blood serum, is discussed in detail. The source of excitation was a 10 A dc arc. Quantitation was achieved with a direct reading emission spectrometer. The metal concentration, in micrograms per 100 ml of blood serum, was calculated from the experimental data by means of a computer.
TL;DR: Isolated cells of Necturus gastric mucosa were prepared with a simple method using pronase digestion and shaking and in dye exclusion tests cell suspensions containing more than 80% of oxyntic cells were more than 90% viable.
TL;DR: The periodc-ntium of premolar teeth of dogs has been examined by scanning electron microscopy and microradiography and reveals a highly developed plexus of indifferent fibers associated with the principal fibers, which may be important in accomodalion of the periodontal ligament to tooth movement through anastomotie relationships between the plexi.
Abstract: The periodc-ntium of premolar teeth of dogs has been examined by scanning electron microscopy. lighl microscopy and microradiography. Scanning electron microscopy reveals a highly developed plexus of indifferent fibers associated with the principal fibers, The indifferent fiber plexus may be important in accomodalion of the periodontal ligament to tooth movement through anastomotie relationships between the plexus and principal fibers. Principal fibers perforate alveolar bone as compact bundles of smaller fibers. Perforating fibers of cementum enter calcified matrix as coiled or straight fibers. The number of coiled fibers is greatest in acellular cementum and the straight fibers are largest in diameter at root apices.
TL;DR: Although the experimental evidence in support of the model was collected from studies of the lactate dehydrogenase (LDH) system in the rat, the model may be generally applicable to other subunit proteins and other organisms.
Abstract: THE molecular basis for the regulation of intracellular concentrations of protein has been studied intensively since the discovery of the transfer of genetic information from DNA to RNA to protein1, 2. We wish to present experimental evidence in support of a model which considers regulation by post-translational events. This model takes into account the contributions of synthesis, degradation and protein interactions to the regulation of intracellular protein concentrations. The model explains how protein concentrations could change within a cell while rates of transcription and translation remained constant. Although the experimental evidence in support of the model was collected from studies of the lactate dehydrogenase (LDH) system in the rat, the model may be generally applicable to other subunit proteins and other organisms.
TL;DR: The data indicate a significant level of infectious drug resistance among the fecal coliforms of the urban population, and that because of the high incidence of coliform bacteria found to be doubly resistant to streptomycin and tetracyline, the inclusion of these antibiotics in selective media used for routine total or fecalcoliform counts may serve to identify domestic sources of pollution.
Abstract: Raw sewage was examined for the incidence of antibiotic-resistant coliforms present among both total and fecal coliforms. In both groups, it was found that approximately 3% of the coliform bacteria were resistant to two or more antibiotics. Of these organisms, 48% were capable of transferring all or part of their antibiotic resistance to an antibiotic-sensitive, F−, derivative of Escherichia coli K-12. Among the R factors identified, those conferring resistance to streptomycin-tetracycline, ampicillin-streptomycin-tetracycline, and ampicillin or ampicillin-streptomycin accounted for 23, 20, and 15%, respectively, of the total R factors detected. The data indicate a significant level of infectious drug resistance among the fecal coliforms of the urban population. The data indicate further that because of the high incidence of coliform bacteria found to be doubly resistant to streptomycin and tetracyline, the inclusion of these antibiotics in selective media used for routine total or fecal coliform counts may serve to identify domestic sources of pollution.
TL;DR: Data provide additional evidence for a structural similarity among phylogenetically distinct immune macroglobulins and suggest a common evolutionary origin among mammalian IgM H and L chains.
TL;DR: The effect of trimetaphosphate ion effect on mineral deposition was studied in this article, showing that small concentrations of the metal in a calcifying solution slowed the rate of calcium and phosphate deposition onto etched enamel and caused the formation of a solid phase, the chemical composition of which approximated that of hydroxyapatite.
Abstract: The effect of trimetaphosphate on mineral deposition was studied. Small concentrations of trimetaphosphate in a calcifying solution slowed the rate of calcium and phosphate deposition onto etched enamel and caused the formation of a solid phase, the chemical composition of which approximated that of hydroxyapatite and fluorapatite. The mechanism of the trimetaphosphate ion effect was due to its accumulation on the enamel mineral surface.
TL;DR: Experiments have been conducted over a period of eight months to evaluate the quality of service provided by dental therapists, and various aspects were evaluated; only a few of the differences were statistically significant.
Abstract: Because of the disparity between the need for dental service and the availability of such service, studies have been made at the University of Alabama School of Dentistry on the expanded use of auxiliary personnel. Recent experiments have been conducted over a period of eight months to evaluate the quality of service provided by dental therapists. Six dentists in private practice, two clinical instructors from the department of operative dentistry, and four dental therapists participated in the research. The six clinical procedures investigated included inserting amalgam restorations, finishing amalgam fillings, finishing silicate cement restorations, inserting temporary restorations, and placing matrix bands for amalgam fillings. Evaluations were made by dental practitioners who were unaware whether the dentists or therapists had completed the procedure. Various aspects were evaluated; only a few of the differences were statistically significant.