Showing papers by "University of Cagliari published in 1975"
TL;DR: Sulpiride appears to be unique in respect to other neuroleptic since according to the experiments reported in this paper it does not block dopamine receptors either in vitro or in vivo.
186 citations
TL;DR: The high plasma Cortisol and ACTH levels present in pregnant women as well as the non‐parallelism of their plasma extract dilution curves in comparison with the standard curve in the ACTH radioimmunoassay are evidence for the presence of an ACTH‐like substance during pregnancy which would interfere with the assay.
Abstract: SUMMARY
The high plasma Cortisol and ACTH levels present in pregnant women as well as the non-parallelism of their plasma extract dilution curves in comparison with the standard curve in the ACTH radioimmunoassay, are evidence for the presence of an ACTH-like substance during pregnancy which would interfere with the assay.
Placental extracts were obtained by acid-acetone extraction, followed by partial purification with oxycellulose and by extraction with porous glass powder. A substance was detected which partially cross-reacted with synthetic human ACTH in the radioimmunoassay and which showed biological activity using the assay procedure described by Lipscomb & Nelson. The data sustain the existence of an ACTH-like placental hormone: human chorionic corticotrophin (HCC).
120 citations
TL;DR: The central action of sulpiride differs from that of classic neuroleptics in that this drug stimulates dopamine turnover without producing catalepsy.
Abstract: —Sulpiride (5–200 mg/kg) increases brain HVA and DOPAC levels, causes no change in dopamine concentration, does not interfere with the outflow of HVA from the CNS and enhances the disappearance of brain dopamine after inhibition of tyrosine hydroxylase. The compound influences neither 5-HT nor NE metabolism. The central action of sulpiride differs from that of classic neuroleptics in that this drug stimulates dopamine turnover without producing catalepsy.
114 citations
TL;DR: In this paper, it was shown that up to four excitonic series in Mo$S 2 can be obtained by photoconductivity, photovoltaic effect and wavelength-modulated reflectivity at temperatures of 300 to 4.2 K and in magnetic fields of up to 70 kG.
Abstract: Optical spectra of Mo${\mathrm{S}}_{2}$ in the excitonic region were obtained by photoconductivity, photovoltaic effect and wavelength-modulated reflectivity at temperatures of 300 to 4.2 K and in magnetic fields of up to 70 kG. Cleaved natural crystals and synthetic crystals studied in both the Faraday and Voigt configurations showed nearly the same characteristics. The results indicate the possibility of up to four excitonic series in Mo${\mathrm{S}}_{2}$ as in other Mo dichalcogenides, and support band-structure calculations predicting flat conduction and valence bands originating from Mo orbitals. A ground-state anomaly of the $A$ exciton is explained by a central cell correction of the type used by Harbeke and Tosatti to explain a similiar anomaly in Pb${\mathrm{I}}_{2}$. The reduced mass of the $A$ exciton is found to be ${\ensuremath{\mu}}^{*}\ensuremath{\simeq}0.4{m}_{0}$, both from the study of the series itself, and from its magneto-optical properties, thus removing a large discrepancy found in previous work.
77 citations
TL;DR: In this paper, a simple model describing the coordination around the ions only in terms of nearest-neighbour interactions is shown to be consistent with experimental data, and octahedral coordination about Br− appears to be sufficiently established.
60 citations
TL;DR: The defect in β-globin-chain synthesis in homozygous β-thalassaemia is expressed in utero, and prenatal diagnosis is possible.
47 citations
TL;DR: The data reported shows that methadone and dextromoramide produced a dose-related increase in homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) content of rat brain.
39 citations
TL;DR: In this paper, the properties of copper(II, nickel(II), cobalt(II) and cobalt (II) with 3-5-dimethylisoxazole (3,5-diMeisox) have been investigated by means of magnetic susceptibility measurements, infrared and far i.r.
38 citations
TL;DR: The results suggest that insulin enhances the transport of tyrosine and tryptophan from blood to brain, and this increase is associated with a parallel decrease in the concentration of free tryPTophan and Tyrosine in serum.
28 citations
TL;DR: In this paper, complexes of the type M(CO) 3 (22cy), where M = Cr, Mo, W and 22cy = 2,2-para-cyclophane were prepared and characterised.
23 citations
01 Jan 1975
TL;DR: The role of brain monoamines in male sexual behavior is described and inhibition of heterosexual copulatory behavior has been observed after the administration of LSD which is considered a direct stimulant of central serotonin receptors.
Abstract: Publisher Summary
This chapter describes the role of brain monoamines in male sexual behavior. The effects of p-chlorophenylalanine (PCPA) administration on the homo- and heterosexual behavior are suppressed in rats, rabbits and cats by 5-hydroxytryptophan, the direct precursor of serotonin. This amino acid also abolishes the spontaneous copulatory behavior of normal rats with receptive females. This inhibition is potentiated by inhibitors of extracerebral decarboxylase, suggesting that 5-HTP acts centrally. The monoamineoxidase inhibitor, pargyline, suppresses the spontaneous copulatory behavior of male rats with receptive females at the time when brain serotonin is maximally increased and inhibition, as well as serotonin accumulation, is prevented by PCPA. Marked homosexual mounting behavior has been observed in male rats after other treatments that lower brain serotonin, such as p-chloro-N-methyl-amphetamine and the intraventricular injection of 5,6 dihydroxytryptamine and furthermore, in testosterone-treated male rats, after different inhibitors of serotonin receptors such as mesorgydine, methysergide and Wa 335-BS . Inhibition of heterosexual copulatory behavior has been observed after the administration of LSD which is considered a direct stimulant of central serotonin receptors.
TL;DR: In this paper, the conductivity measurements of 3-methyl-5-phenylisoxazole derivatives of cobalt, nickel, copper and perchlorates are reported.
TL;DR: The arrangement of chromosomes in interphase nuclei of Anopheles atroparvus has been inferred from an analysis of the early stages of mitosis as seen following Quinacrine staining, and a peripheral arrangement of the interphase somatic complement is indicated.
Abstract: The arrangement of chromosomes in interphase nuclei of Anopheles atroparvus has been inferred from an analysis of: 1. The early stages of mitosis as seen following Quinacrine staining, and 2. The reversible effects on the chromatin pattern obtained following the treatment of living cells with various NaCl solutions, and the following conclusions have been reached: (a) The chromatin is connected to the nuclear membrane, (b) Homologous chromosomes show close side-by-side somatic pairing, (c) The long arms of the sex chromosomes form a fluorescent peripheral body, (d) The autosomes are strongly reflexed at the centromeres, (e) The autosomal centromeric regions are polarized towards the peripheral body, (f) The telomeric regions of all the autosomes are closely apposed. — A ring-shaped pattern of interphase chromatin is constantly and reversibly induced by NaCl 0.15 to 0.18 M solutions. — These relationships indicate a peripheral arrangement of the interphase somatic complement. — The distribution of the chromosomes in polytene nuclei and at the beginning of meiosis resembles that suggested above for somatic interphase cells. This distribution may apply more widely in the Diptera.
TL;DR: The complexes of palladium(II), platinum(II) halides and palladium nitrate and thiocyanate with isoxazole and 3,5-dimethylisoxazoles have been prepared and characterized by spectroscopic methods and conductivity measurements as discussed by the authors.
TL;DR: These results, in conjunction with the sedative and cataleptigenic action of this compound, support evidence for a neuroleptic activity of metoclopramide.
TL;DR: Cette souche de virus herpétique résistant à l'IUdR est très peu virulente chez la souris and le lapin, mais est capable of protéger ces animaux contre le virus pathogène d'origine.
Abstract: Par passage en serie sur des cellules en culture et en presence de 5-iodo-2-desoxyuridine (IUdR) on a obtenu une souche de virus herpetique resistant a l'IUdR. Cette souche est tres peu virulente chez la souris et le lapin, mais est capable de proteger ces animaux contre le virus pathogene d'origine.
TL;DR: In this article, an analysis of the isothermal decay curves has been performed assuming that the light emission consists of a sum of exponential decays with different time constants τi, taking into account the dependence of τi from temperature, the values of thermal activation energies of the trapping centres involved in the luminescence process are obtained.
TL;DR: In this article, the authors present a procedimento, basato sulla costruzione di basi locali di splines naturali, per la costruzzione di tali soluzioni.
Abstract: In questa nota vengono dapprima presentati i teoremi di esistenza ed unicita (in opportuni spazi) delle smoothing splines naturali mono e bidimensionali, soluzioni rispettivamente dei problemi (1,5)–(1,6) e (4,5)–(4,6). Viene quindi indicato un procedimento, basato sulla costruzione di basi locali di splines naturali, per la costruzione di tali soluzioni. Infine viene presentato un metodo generale per la costruzione di tali basi.
TL;DR: In this article, the thermoluminescent emissions of some aromatic hydrocarbon crystals have been investigated as excited at liquid N 2 temperature by UV light and diffusion scattering measurements have been also performed for determining the absorption and excitation spectra.
TL;DR: In this article, a simple theoretical model for the transition of antimony from the explosive amorphous phase to the stable crystalline phase has been proposed, and the energy released by this transition is measured to be 24 cal per gram of amorphized Sb and is related to a variation of the mass density and of the conductivity behaviour of Sb going from one configuration to the other.
Abstract: The transition of antimony from the explosive amorphous phase to the stable crystalline phase has been studied both from an experimental point of view as well as from a theoretical one. The energy released by this transition, is measured to be 24 cal per gram of amorphous Sb and is shown to be related to a variation of the mass density and of the conductivity behaviour of Sb going from one configuration to the other. A simple theoretical model is outlined which quite satisfactory gives the gross features of the free-energy diagram of the above transition, although more deep investigation is needed to account for the energy balance of it.
On a etudie d'un point de vue theorique et experimental la transition de la phase amorpheexplosive a la phase cristalline-stable de l'Antimoine. On a mesure la chaleur de transition, 24 cal pour gram de Sb amorphe et on a montre sa correlation avec la variation de densite et de conductivite pendant le changement de phase. Le simple model theorique propose explique d'une facLon assez satisfaisante le comportement general du diagram de l'energie libre de la transition, bien que une etude plus detaillee serait necessaire pour le bilan energetique.
TL;DR: Les résultats obtenus démontrent que l'ACTH maternelle ne passe pas au-delà de la barrière placentaire and confirment l'indépendance foetale des concentrations plasmatiques d' ACTH.
Abstract: Les auteurs, utilisant de l'ACTH-I125, ont etudie le probleme de la permeabilite placentaire a cette hormone chez la lapine. Les resultats obtenus demontrent que l'ACTH maternelle ne passe pas au-dela de la barriere placentaire et confirment l'independance foetale des concentrations plasmatiques d'ACTH.
TL;DR: In this paper, a series of complexes of the type M(L)(SCN) x (ClO 4 ) 2−x (where M = Zn(II), Cd(II, Hg(II); L = ethylenediamine (en), N,N,N′, N′, n′-tetramethylethylenedamine (Me 4 en), diethylenetriamine (den), N.N.N′-pentamethyl-den (Me 5 den), triethylenet
TL;DR: In this paper, the problem of thermoluminescence building-up, that is, of the carrier production and storage during the phosphor excitation, is faced by the same kinetic model which allows for the thermolumininescent emission, for the carrier recombinations.
TL;DR: In this paper, a method is proposed which, starting from kinetic equations, allows us to determine the parameters involved in the thermoluminescent process, unlike some previous ones, does not require any troublesome calculations, and thus turns out to be readily applicable.
TL;DR: The long arms of the X and Y chromosomes of the mosquito Anopheles atroparvus are equal in length, synchronous in their late DNA replication and have homologous G and Q bands, indicating differentiation of the two sex chromosomes was the consequence of a single event such as a single deletion of an autosome.
Abstract: The long arms of the X and Y chromosomes of the mosquito Anopheles atroparvus (2n = 6) are equal in length, synchronous in their late DNA replication and have homologous G and Q bands. This indicates that differentiation of the two sex chromosomes was the consequence of a single event such as a single deletion of an autosome to give the Y chromosome, not followed by the acquisition of differential heterochromatic blocks.
TL;DR: In this article, a series of compounds whose general formula is Cu L(SCN)Y, where L = bis(ethylenediamine) (en2), bis(1,3-diaminopropane) (tn2), diethylenetriamine (den), N,N,N′,N″,N'',N ''-pentamethyl-den(Me5den), 3,3′-dieninodipropylamine (dpt), 2,2′,2″-triaminotri
TL;DR: The PHA-resposiveness of normal and Hodgkin patient human peripheral blood lymphocytes has been studied and data are in agreement with the hypothesis that the presence of serum cytotoxin is at least partly responsible for the immuno-incompetence of T-lymphocytes characteristic of Hodgkin's disease.
Abstract: The PHA-resposiveness of normal and Hodgkin patient human peripheral blood lymphocytes has been studied before and after incubation with Hodgkin cytotoxic sera. The following conclusions have been reached: (a) Hodgkin cytotoxic serum is capable of decreasing the PHA-responsiveness of normal lymphocytes and of furtherly impairing the already defective PHA-responsiveness of Hodgkin lymphocytes. (b) The impaired PHA-responsiveness can be restored to the original levels by eluting the cytotoxic antibody. Control experiments in which normal and Hodgkin lymphocytes were put in contact with normal and Hodgkin non-cytotoxic serum showed no decrease of PHA-responsiveness. These data are in agreement with the hypothesis that the presence of serum cytotoxin is at least partly responsible for the immuno-incompetence of T-lymphocytes characteristic of Hodgkin's disease.
TL;DR: In this paper, the thermoluminescent emission of phenanthrene crystals, UV excited at liquid N2 temperature, was investigated on the basis of a previously proposed kinetic model.