Institution
University of Newcastle
Education•Newcastle, New South Wales, Australia•
About: University of Newcastle is a education organization based out in Newcastle, New South Wales, Australia. It is known for research contribution in the topics: Population & Health care. The organization has 19211 authors who have published 51893 publications receiving 1694726 citations. The organization is also known as: Newcastle University.
Topics: Population, Health care, Context (language use), Poison control, Randomized controlled trial
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors present an automated approach based on literature analysis and synthesis for establishing the dimensions of the ethnic marketing literature, covering a set of 239 journal articles published by nine major publishers.
48 citations
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TL;DR: Exercise-related variety support holds potential to be an efficacious method for facilitating greater exercise adherence behaviors of previously inactive people by fostering perceptions of variety.
Abstract: The purpose of this study was to examine the extent to which the provision of variety (i.e., variety support) is related to exercise behavior among physically inactive adults and the extent to which the 'experience of variety' mediates those effects. One hundred and twenty one inactive university students were randomly assigned to follow a high or low variety support exercise program for 6 weeks. Assessments were conducted at baseline, 3- and 6-weeks. Participants in the high variety support condition displayed higher levels of adherence to the exercise program than those in the low variety support condition [F(1, 116) = 5.55, p = .02, η(p)(2) = .05] and the relationship between variety support and adherence was mediated by perceived variety (β = .16, p < .01). Exercise-related variety support holds potential to be an efficacious method for facilitating greater exercise adherence behaviors of previously inactive people by fostering perceptions of variety.
48 citations
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04 Apr 2006
TL;DR: In this article, a method for an on-line junction temperature measurement is introduced, which allows the calibration of a real-time thermal model of a power MOSFET.
Abstract: A method for an on-line junction temperature measurement is introduced. The circuit allows the calibration of a real-time thermal model of a power MOSFET. A regular calibration of the real-time model provides an accurate thermal flux model over the lifetime of the power MOSFET. The measurement of threshold voltage is used to determine the device temperature. The paper presents the on-line measurement method, the circuit and test results.
48 citations
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Wellcome Trust Centre for Human Genetics1, University of Oxford2, University of Maryland, Baltimore3, National Institutes of Health4, University of Arkansas for Medical Sciences5, Queen Mary University of London6, Wellcome Trust Sanger Institute7, The Chinese University of Hong Kong8, University of Chicago9, University of Newcastle10, Shanghai Jiao Tong University11, Imperial College London12
TL;DR: The gene encoding the transcription factor upstream stimulatory factor (USF)1 influences susceptibility to familial combined hyperlipidemia (FCHL) and triglyceride levels, and typing 22 variants in the F11R/USF1 region reveals only limited evidence for replication of USF1 effects on continuous metabolic traits.
Abstract: The gene encoding the transcription factor upstream stimulatory factor (USF)1 influences susceptibility to familial combined hyperlipidemia (FCHL) and triglyceride levels. Phenotypic overlap between FCHL and type 2 diabetes makes USF1 a compelling positional candidate for the widely replicated type 2 diabetes linkage signal on chromosome 1q. We typed 22 variants in the F11R/USF1 region (1 per 3 kb), including those previously implicated in FCHL-susceptibility (or proxies thereof) in 3,726 samples preferentially enriched for 1q linkage. We also examined glucose- and lipid-related continuous traits in an overlapping set of 1,215 subjects of European descent. There was no convincing evidence for association with type 2 diabetes in any of seven case-control comparisons, individually or combined. Family-based association analyses in 832 Pima subjects were similarly negative. At rs3737787 (the variant most strongly associated with FCHL), the combined odds ratio, per copy of the rarer A-allele, was 1.10 (95% CI 0.97-1.24, P = 0.13). In 124 Utah subjects, rs3737787 was significantly associated (P = 0.002) with triglyceride levels, but direction of this association was opposite to previous reports, and there was no corroboration in three other samples. These data exclude USF1 as a major contributor to type 2 diabetes susceptibility and the basis for the chromosome 1q linkage. They reveal only limited evidence for replication of USF1 effects on continuous metabolic traits.
48 citations
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TL;DR: This article developed a model of thromboembolic stroke in rats with site-specific delivery of platelet-rich clots (PRC) to the main stem of the middle cerebral artery (MCA), which was used in a subsequent study to test microbubble-enhanced sonothrombolysis.
Abstract: Early recanalization of occluded vessels in stroke is closely associated with improved clinical outcome. Microbubble-enhanced sonothrombolysis is a promising therapy to improve recanalization rates and reduce the time to recanalization. Testing any thrombolytic therapy requires a model of thromboembolic stroke, but to date these models have been highly variable with regards to clot stability. Here, we developed a model of thromboembolic stroke in rats with site-specific delivery of platelet-rich clots (PRC) to the main stem of the middle cerebral artery (MCA). This model was used in a subsequent study to test microbubble-enhanced sonothrombolysis. In Study 1 we investigated spontaneous recanalization rates of PRC in vivo over 4 hours and measured infarct volumes at 24 hours. In Study 2 we investigated tPA-mediated thrombolysis and microbubble-enhanced sonothrombolysis in this model. Study 1 demonstrated stable occlusion out to 4 hours in 5 of 7 rats. Two rats spontaneously recanalized at 40 and 70 minutes post-embolism. Infarct volumes were not significantly different in recanalized rats, 43.93 ± 15.44% of the ischemic hemisphere, compared to 48.93 ± 3.9% in non-recanalized animals (p = 0.7). In Study 2, recanalization was not observed in any of the groups post-treatment. Site specific delivery of platelet rich clots to the MCA origin resulted in high rates of MCA occlusion, low rates of spontaneous clot lysis and large infarction. These platelet rich clots were highly resistant to tPA with or without microbubble-enhanced sonothrombolysis. This resistance of platelet rich clots to enhanced thrombolysis may explain recanalization failures clinically and should be an impetus to better clot-type identification and alternative recanalization methods.
48 citations
Authors
Showing all 19437 results
Name | H-index | Papers | Citations |
---|---|---|---|
Graham A. Colditz | 261 | 1542 | 256034 |
Martin White | 196 | 2038 | 232387 |
David W. Bates | 159 | 1239 | 116698 |
Nicholas J. Talley | 158 | 1571 | 90197 |
David Cameron | 154 | 1586 | 126067 |
Stephen J. O'Brien | 153 | 1062 | 93025 |
David J. Brooks | 152 | 1056 | 94335 |
Rui Zhang | 151 | 2625 | 107917 |
David Goldstein | 141 | 1301 | 101955 |
Graeme J. Hankey | 137 | 844 | 143373 |
Peter M. Rothwell | 134 | 779 | 67382 |
John F. Thompson | 132 | 1420 | 95894 |
Peter A. Jones | 130 | 513 | 81683 |
David Smith | 129 | 2184 | 100917 |
Christopher G. Maher | 128 | 940 | 73131 |