C
Christopher R Levi
Researcher at John Hunter Hospital
Publications - 388
Citations - 19241
Christopher R Levi is an academic researcher from John Hunter Hospital. The author has contributed to research in topics: Stroke & Perfusion scanning. The author has an hindex of 64, co-authored 354 publications receiving 15936 citations. Previous affiliations of Christopher R Levi include University of Newcastle & University of Maryland, Baltimore.
Papers
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Journal ArticleDOI
Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial.
Stephen M. Davis,Geoffrey A. Donnan,Mark W Parsons,Christopher R Levi,Kenneth Butcher,André Peeters,P. Alan Barber,Christopher F. Bladin,Deidre A. De Silva,Graham Byrnes,Jonathan B. Chalk,John N. Fink,Thomas E. Kimber,David Schultz,Peter J. Hand,Judith Frayne,Graeme J. Hankey,Keith W. Muir,Richard P. Gerraty,Brian M. Tress,Patricia Desmond +20 more
TL;DR: Alteplase was non-significantly associated with lower infarct growth and significantly associated with increased reperfusion in patients who had mismatch, and phase III trials beyond 3 h after treatment are warranted.
Journal Article
Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial
Stephen M. Davis,Geoffrey A. Donnan,Mark W Parsons,Christopher R Levi,Kenneth Butcher,André Peeters,Peter Barber,Christopher F. Bladin,Deidre A De Silva,Graham Byrnes,Jonathan B Chalk,John N. Fink,Thomas E. Kimber,David Schultz,Peter J. Hand,Judith Frayne,Graeme J. Hankey,Keith W. Muir,Richard P. Gerraty,Brian M. Tress,Patricia Desmond +20 more
TL;DR: In this paper, Alteplase was shown to promote reperfusion and attenuate infarct growth in patients who have a mismatch in perfusion-weighted MRI (PWI) and diffusion weighted MRI (DWI).
Journal ArticleDOI
A randomized trial of tenecteplase versus alteplase for acute ischemic stroke.
Mark W Parsons,Neil J. Spratt,Andrew Bivard,Bruce C.V. Campbell,Kong Chung,Ferdinand Miteff,Bill O'Brien,Christopher F. Bladin,Patrick McElduff,Chris Allen,Grant A. Bateman,Geoffrey A. Donnan,Stephen M. Davis,Christopher R Levi +13 more
TL;DR: Tenecteplase was associated with significantly better reperfusion and clinical outcomes than alteplase in patients with stroke who were selected on the basis of CT perfusion imaging.
Journal ArticleDOI
Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke
Bruce C.V. Campbell,Peter Mitchell,Leonid Churilov,Nawaf Yassi,Timothy Kleinig,Richard Dowling,Bernard Yan,Steven Bush,Helen M Dewey,Vincent Thijs,Vincent Thijs,Rebecca Scroop,Marion Simpson,Mark Brooks,Hamed Asadi,Hamed Asadi,Hamed Asadi,Teddy Y. Wu,Teddy Y. Wu,Darshan Shah,Darshan Shah,Tissa Wijeratne,Timothy Ang,Ferdinand Miteff,Christopher R Levi,Edrich Rodrigues,Henry Zhao,Patrick Salvaris,Carlos Garcia-Esperon,Peter L. Bailey,Henry E. Rice,Laetitia de Villiers,Helen Brown,Kendal Redmond,David Leggett,John N. Fink,Wayne Collecutt,Andrew Wong,Claire Muller,Alan Coulthard,Ken Mitchell,John Clouston,Kate Mahady,Deborah Field,Henry Ma,Thanh G. Phan,Winston Chong,Ronil V. Chandra,Lee-Anne Slater,Martin Krause,Timothy Harrington,Timothy Harrington,Kenneth Faulder,Kenneth Faulder,Brendan Steinfort,Brendan Steinfort,Christopher F. Bladin,Christopher F. Bladin,Gagan Sharma,Patricia Desmond,Mark W Parsons,Geoffrey A. Donnan,Stephen M. Davis +62 more
TL;DR: Tenecteplase before thrombectomy was associated with a higher incidence of reperfusion and better functional outcome than alteplase among patients with ischemic stroke treated within 4.5 hours after symptom onset.
Journal ArticleDOI
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
Matthew Traylor,Martin Farrall,Elizabeth G. Holliday,Cathie Sudlow,Jemma C. Hopewell,Yu-Ching Cheng,Myriam Fornage,M. Arfan Ikram,Rainer Malik,Steve Bevan,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Mike A. Nalls,W. T. Longstreth,Kerri L. Wiggins,Sunaina Yadav,Eugenio Parati,Anita L. DeStefano,Bradford B. Worrall,Steven J. Kittner,Muhammad Saleem Khan,Alexander P. Reiner,Anna Helgadottir,Anna Helgadottir,Anna Helgadottir,Sefanja Achterberg,Israel Fernandez-Cadenas,Sherine Abboud,Reinhold Schmidt,Matthew Walters,Wei-Min Chen,Wei-Min Chen,E. Bernd Ringelstein,Martin O'Donnell,Weang Kee Ho,Joanna Pera,Robin Lemmens,Bo Norrving,Peter Higgins,Marianne Benn,Michèle M. Sale,Gregor Kuhlenbäumer,Alex S. F. Doney,Astrid M. Vicente,Hossein Delavaran,Ale Algra,Gail Davies,Sofia A. Oliveira,Colin N. A. Palmer,Ian C. Deary,Helena Schmidt,Massimo Pandolfo,Joan Montaner,Cara L. Carty,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Konstantinos Kostulas,José M. Ferro,Natalie R. van Zuydam,Einar M. Valdimarsson,Børge G. Nordestgaard,Arne Lindgren,Vincent Thijs,Agnieszka Slowik,Danish Saleheen,Danish Saleheen,Guillaume Paré,Klaus Berger,Gudmar Thorleifsson,Albert Hofman,Thomas H. Mosley,Braxton D. Mitchell,Karen L. Furie,Robert Clarke,Christopher R Levi,Sudha Seshadri,Andreas Gschwendtner,Giorgio B. Boncoraglio,Pankaj Sharma,Joshua C. Bis,Solveig Gretarsdottir,Bruce M. Psaty,Peter M. Rothwell,Jonathan Rosand,Jonathan Rosand,Jonathan Rosand,James F. Meschia,Kari Stefansson,Kari Stefansson,Martin Dichgans,Hugh S. Markus +91 more
TL;DR: The results show that, although genetic variants can be detected in patients with ischaemic stroke when compared with controls, all associations validated are specific to a stroke subtype, and this finding has two implications.