University of Peshawar

About: University of Peshawar is a education organization based out in Peshawar, Pakistan. It is known for research contribution in the topics: Adsorption & Population. The organization has 2461 authors who have published 4963 publications receiving 76525 citations. The organization is also known as: Peshawar University & UoP.

Diabetes mellitus and oxidative stress—A concise review

Abstract: Human body is continuously exposed to different types of agents that results in the production of reactive species called as free radicals (ROS/RNS) which by the transfer of their free unpaired electron causes the oxidation of cellular machinery. In order to encounter the deleterious effects of such species, body has got endogenous antioxidant systems or it obtains exogenous antioxidants from diet that neutralizes such species and keeps the homeostasis of body. Any imbalance between the RS and antioxidants leads to produce a condition known as “oxidative stress” that results in the development of pathological condition among which one is diabetes. Most of the studies reveal the inference of oxidative stress in diabetes pathogenesis by the alteration in enzymatic systems, lipid peroxidation, impaired Glutathione metabolism and decreased Vitamin C levels. Lipids, proteins, DNA damage, Glutathione, catalane and superoxide dismutase are various biomarkers of oxidative stress in diabetes mellitus. Oxidative stress induced complications of diabetes may include stroke, neuropathy, retinopathy and nephropathy. The basic aim of this review was to summarize the basics of oxidative stress in diabetes mellitus.

The closing of Tethys and the tectonics of the Himalaya

Abstract: Recent geological and geophysical data from southern Tibet allow refinement of models for the closing of southern (Neo-) Tethys and formation of the Himalaya. Shelf sediments of the Indian passive continental margin which pass northward into deep-sea Tethyan sediments of the Indus-Tsangpo suture zone were deposited in the Late Cretaceous. An Andean-type margin with a 2,500-km-long Trans-Himalayan (Kohistan-Ladakh-Gangdese) granitoid batholith formed parallel to the southern margin of the Lhasa block, together with extensive andesites, rhyolites, and ignimbrites (Lingzizong Formation). The southern part of the Lhasa block was uplifted, deformed, and eroded between the Cenomanian and the Eocene. In the western Himalaya, the Kohistan island arc became accreted to the northern plate at this time. The northern part of the Lhasa block was affected by Jurassic metamorphism and plutonism associated with the mid-Jurassic closure of the Bangong-Nujiang suture zone to the north. The timing of collision between the two continental plates (ca. 50-40 Ma) marking the closing of Tethys is shown by (1) the change from marine (flysch-like) to continental (molasse-like) sedimentation in the Indus-Tsangpo suture zone, (2) the end of Gangdese I-type granitoid injection, (3) Eocene S-type anatectic granites and migmatites in the Lhasa block, and (4) the start of compressional tectonics in the Tibetan-Tethys and Indus-Tsangpo suture zone (south-facing folds, south-directed thrusts). After the Eocene closure of Tethys, deformation spread southward across the Tibetan-Tethys zone to the High Himalaya. Deep crustal thrusting, Barrovian metamorphism, migmatization, and generation of Oligocene-Miocene leucogranites were accompanied by south-verging recumbent nappes inverting metamorphic isograds and by south-directed intracontinental shear zones associated with the Main Central thrust. Continued convergence in the late Tertiary resulted in large-scale north-directed backthrusting along the Indus-Tsangpo suture zone. More than 500 km shortening is recorded in the foreland thrust zones of the Indian plate, south of the suture, and > 150 km shortening is recorded across the Indian shelf (Zanskar Range) and the Indus suture in Ladakh. There was also large-scale shortening of the Karakoram and Tibetan microplates north of the suture; as much as 1,000 km shortening occurred in Tibet. The more recent deformation, however, involved the spreading of this thickened crust and the lateral motion of the Tibetan block along major approximately east-west–trending strike-slip fault zones.

The uptake and bioaccumulation of heavy metals by food plants, their effects on plants nutrients, and associated health risk: a review.

Abstract: Heavy metal contamination is a globally recognized environmental issue, threatening human life very seriously. Increasing population and high demand for food resulted in release of various contaminants into environment that finally contaminate the food chain. Edible plants are the major source of diet, and their contamination with toxic metals may result in catastrophic health hazards. Heavy metals affect the human health directly and/or indirectly; one of the indirect effects is the change in plant nutritional values. Previously, a number of review papers have been published on different aspects of heavy metal contamination. However, no related information is available about the effects of heavy metals on the nutritional status of food plants. This review paper is focused upon heavy metal sources, accumulation, transfer, health risk, and effects on protein, amino acids, carbohydrates, fats, and vitamins in plants. The literature about heavy metals in food plants shows that both leafy and nonleafy vegetables are good accumulators of heavy metals. In nonleafy vegetables, the bioaccumulation pattern was leaf > root ≈ stem > tuber. Heavy metals have strong influence on nutritional values; therefore, plants grown on metal-contaminated soil were nutrient deficient and consumption of such vegetables may lead to nutritional deficiency in the population particularly living in developing countries which are already facing the malnutrition problems.

Stratigraphic evidence for an early collision between northwest India and Asia

Abstract: THE collision of India with Asia1 had a profound influence on late Cretaceous and Cenozoic oceanography2, climate3, fauna! extinctions4 and the motion of at least some of the Earth's litho-spheric plates5. As the collision ended a period of rapid Indo-Asian convergence6, a precise knowledge of its timing (when the crust of the neo-Tethys ocean was completely subducted7, at some point along the plate boundary) is important for understanding its wider consequences. But current estimates of the collision age range from 65 to 38 Myr before present6, 8–11. Here we report the results of extensive biostratigraphic analyses from Waziristan and Kurram in northwest Pakistan, which show that accretionary-prism and trench strata were first thrust onto the northwest Indian passive margin after 66 Myr but before 55.5 Myr. After this time, volcanic-arc fragments, the accretionary prism, trench material and imbricates of the north Indian slope were raised to shallow water depths and overlapped by upper Palaeocene shallow-water carbonates and shales12–14, indicative of post-collision thrusting in this region. Finally, both the suture and the Indian craton were overlapped by continuous unconformable upper Lower Eocene shallow-marine strata, demonstrating that suturing was complete by 49 Myr.