Institution
University of Quindío
Education•Armenia, Colombia•
About: University of Quindío is a education organization based out in Armenia, Colombia. It is known for research contribution in the topics: Population & Toxoplasmosis. The organization has 1691 authors who have published 1664 publications receiving 9762 citations.
Papers published on a yearly basis
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McMaster University1, Université du Québec2, St. John's University3, University of the Philippines Manila4, Semmelweis University5, University of Cape Town6, Centra7, Uppsala University8, UCSI University9, Technion – Israel Institute of Technology10, University of Leicester11, Curtin University12, Alfred Hospital13, University of Quindío14, Cardiovascular Institute of the South15
TL;DR: Treatment with rosuvastatin at a dose of 10 mg per day resulted in a significantly lower risk of cardiovascular events than placebo in an intermediate-risk, ethnically diverse population without cardiovascular disease.
Abstract: BackgroundPrevious trials have shown that the use of statins to lower cholesterol reduces the risk of cardiovascular events among persons without cardiovascular disease. Those trials have involved persons with elevated lipid levels or inflammatory markers and involved mainly white persons. It is unclear whether the benefits of statins can be extended to an intermediate-risk, ethnically diverse population without cardiovascular disease. MethodsIn one comparison from a 2-by-2 factorial trial, we randomly assigned 12,705 participants in 21 countries who did not have cardiovascular disease and were at intermediate risk to receive rosuvastatin at a dose of 10 mg per day or placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, and the second coprimary outcome additionally included revascularization, heart failure, and resuscitated cardiac arrest. The median follow-up was 5.6 years. ResultsThe overall mean low-density lipop...
640 citations
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TL;DR: In this paper, the polymorphic pseudokinase ROP5 determines strain differences in virulence through an unknown mechanism, which can only inhibit accumulation of the immunity-related GTPases on the parasitophorous vacuole membrane (PVM) of strains that also express virulent Rop5 alleles.
Abstract: The obligate intracellular parasite Toxoplasma gondii secretes effector proteins into the host cell that manipulate the immune response allowing it to establish a chronic infection. Crosses between the types I, II and III strains, which are prevalent in North America and Europe, have identified several secreted effectors that determine strain differences in mouse virulence. The polymorphic rhoptry protein kinase ROP18 was recently shown to determine the difference in virulence between type I and III strains by phosphorylating and inactivating the interferon-γ (IFNγ)-induced immunity-related GTPases (IRGs) that promote killing by disrupting the parasitophorous vacuole membrane (PVM) in murine cells. The polymorphic pseudokinase ROP5 determines strain differences in virulence through an unknown mechanism. Here we report that ROP18 can only inhibit accumulation of the IRGs on the PVM of strains that also express virulent ROP5 alleles. In contrast, specific ROP5 alleles can reduce IRG coating even in the absence of ROP18 expression and can directly interact with one or more IRGs. We further show that the allelic combination of ROP18 and ROP5 also determines IRG evasion and virulence of strains belonging to other lineages besides types I, II and III. However, neither ROP18 nor ROP5 markedly affect survival in IFNγ-activated human cells, which lack the multitude of IRGs present in murine cells. These findings suggest that ROP18 and ROP5 have specifically evolved to block the IRGs and are unlikely to have effects in species that do not have the IRG system, such as humans.
193 citations
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TL;DR: Prevalence of T. gondii was determined in serum, feces, and tissues of 170 unwanted cats from Colombia, South America and mice inoculated with tissues of 12 of 15 infected cats died of toxoplasmosis; with nine T. Gondii isolates all infected mice died.
185 citations
01 Jun 2012
TL;DR: It is reported that ROP18 can only inhibit accumulation of the IRGs on the PVM of strains that also express virulent ROP5 alleles, and that the allelic combination of Rop18 and Rop5 also determines IRG evasion and virulence of strains belonging to other lineages besides types I, II and III.
Abstract: The obligate intracellular parasite Toxoplasma gondii secretes effector proteins into the host cell that manipulate the immune response allowing it to establish a chronic infection. Crosses between the types I, II and III strains, which are prevalent in North America and Europe, have identified several secreted effectors that determine strain differences in mouse virulence. The polymorphic rhoptry protein kinase ROP18 was recently shown to determine the difference in virulence between type I and III strains by phosphorylating and inactivating the interferon-γ (IFNγ)-induced immunity-related GTPases (IRGs) that promote killing by disrupting the parasitophorous vacuole membrane (PVM) in murine cells. The polymorphic pseudokinase ROP5 determines strain differences in virulence through an unknown mechanism. Here we report that ROP18 can only inhibit accumulation of the IRGs on the PVM of strains that also express virulent ROP5 alleles. In contrast, specific ROP5 alleles can reduce IRG coating even in the absence of ROP18 expression and can directly interact with one or more IRGs. We further show that the allelic combination of ROP18 and ROP5 also determines IRG evasion and virulence of strains belonging to other lineages besides types I, II and III. However, neither ROP18 nor ROP5 markedly affect survival in IFNγ-activated human cells, which lack the multitude of IRGs present in murine cells. These findings suggest that ROP18 and ROP5 have specifically evolved to block the IRGs and are unlikely to have effects in species that do not have the IRG system, such as humans.
184 citations
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TL;DR: In this paper, the effect of the sucrose solution concentration on the process kinetics and yield during osmotic dehydration of mango cylinders has been studied and the effective diffusion coefficients in the fruit liquid phase were also estimated.
172 citations
Authors
Showing all 1708 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jorge Enrique Gómez-Marín | 28 | 94 | 2231 |
César A. Collazos | 21 | 374 | 2407 |
Miguel A. Redondo | 20 | 136 | 1450 |
Manuel Ortega | 19 | 147 | 1272 |
Donald C. Taphorn | 19 | 93 | 1784 |
Alejandra de-la-Torre | 18 | 70 | 948 |
Diego Arias | 17 | 45 | 1083 |
Beatriz Guzmán | 17 | 32 | 991 |
Héctor Fabio Bermúdez Orozco | 16 | 39 | 1827 |
Enrique Arbeláez-Cortés | 14 | 42 | 712 |
Ana I. Molina | 14 | 82 | 689 |
Diego Patino | 13 | 104 | 713 |
Fernando Vargas-Salinas | 12 | 50 | 399 |
Hugo Mantilla-Meluk | 11 | 57 | 451 |
Patricia Landázuri | 11 | 60 | 420 |