University of Trás-os-Montes and Alto Douro

About: University of Trás-os-Montes and Alto Douro is a education organization based out in Vila Real, Portugal. It is known for research contribution in the topics: Population & Context (language use). The organization has 2858 authors who have published 7146 publications receiving 138394 citations. The organization is also known as: University of Tras-os-Montes and Alto Douro & UTAD.

Effects of coaches' timeouts on basketball teams' offensive and defensive performances according to momentary differences in score and game period

Abstract: The aim of the present study was to assess the effects of game timeouts on basketball teams' offensive and defensive performances according to momentary differences in score and game period. The sample consisted of 144 timeouts registered during 18 basketball games randomly selected from the 2007 European Basketball Championship (Spain). For each timeout, five ball possessions were registered before (n=493) and after the timeout (n=475). The offensive and defensive efficiencies were registered across the first 35 min and last 5 min of games. A k-means cluster analysis classified the timeouts according to momentary score status as follows: losing (−10 to −3 points), balanced (−2 to 3 points), and winning (4 to 10 points). Repeated-measures analysis of variance identified statistically significant main effects between pre and post timeout offensive and defensive values. Chi-square analysis of game period identified a higher percentage of timeouts called during the last 5 min of a game compared with...

ACE I/D and ACTN3 R/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli

Abstract: Genetic variation of the human ACE I/D and ACTN3 R577X polymorphisms subsequent to 12 weeks of high-speed power training on maximal strength (1RM) of the arm and leg muscles, muscle power performance (counter-movement jump), and functional capacity (sit-to-stand test) was examined in older Caucasian women [n = 139; mean age 65.5 (8.2) years; 67.0 (10.0) kg and 1.57 (0.06) m]. Chelex 100 was used for DNA extraction, and genotype was determined by PCR-RFLP methods. Muscular strength, power, and functional testing were conducted at baseline (T1) and after 12 weeks (T2) of high-speed power training. At baseline, the ACE I/D and ACTN3 R/X polymorphisms were not associated with muscle function or muscularity phenotypes in older Caucasian women. After the 12-week high-speed training program, subjects significantly increased their muscular and functional capacity performance (p < 0.05). For both polymorphisms, significant genotype-training interaction (p < 0.05) was found in all muscular performance indices, except for 1RM leg extension in the ACE I/D (p = 0.187). Analyses of the combined effects between genotypes showed significant differences in all parameters (p < 0.05) in response to high-speed power training between the power (ACTN3 RR + RX & ACE DD) versus “non-power” muscularity-oriented genotypes (ACTN3 XX & ACE II + ID)]. Our data suggest that the ACE and ACTN3 genotypes (single or combined) exert a significant influence in the muscle phenotypes of older Caucasian women in response to high-speed power training. Thus, the ACE I/D and ACTN3 R/X polymorphisms are likely factors in modulating exercise-related phenotypes in older women, particularly in response to a resistance training stimuli.

Hydrodynamic analysis of different thumb positions in swimming

Abstract: The aim of the present study was to analyze the hydrodynamic characteristics of a true model of a swimmer hand with the thumb in different positions using numerical simulation techniques. A three-dimensional domain was created to simulate the fluid flow around three models of a swimmer hand, with the thumb in different positions: thumb fully abducted, partially abducted, and adducted. These three hand models were obtained through computerized tomography scans of an Olympic swimmer hand. Steady-state computational fluid dynamics analyses were performed using the Fluent ® code. The forces estimated in each of the three hand models were decomposed into drag and lift coefficients. Angles of attack of hand models of 0o, 45o and 90o, with a sweep back angle of 0o were used for the calculations. The results showed that the position with the thumb adducted presented slightly higher values of drag coefficient compared with thumb abducted positions. Moreover, the position with the thumb fully abducted allowed increasing the lift coefficient of the hand at angles of attack of 0o and 45o. These results suggested that, for hand models in which the lift force can play an important role, the abduction of the thumb may be better, whereas at higher angles of attack, in which the drag force is dominant, the adduction of the thumb may be preferable.

Haemocompatibility of iron oxide nanoparticles synthesized for theranostic applications: a high-sensitivity microfluidic tool

Abstract: The poor heating efficiency of the most reported magnetic nanoparticles (MNPs), allied to the lack of comprehensive biocompatibility and haemodynamic studies, hampers the spread of multifunctional nanoparticles as the next generation of therapeutic bio-agents in medicine. The present work reports the synthesis and characterization, with special focus on biological/toxicological compatibility, of superparamagnetic nanoparticles with diameter around 18 nm, suitable for theranostic applications (i.e. simultaneous diagnosis and therapy of cancer). Envisioning more insights into the complex nanoparticle-red blood cells (RBCs) membrane interaction, the deformability of the human RBCs in contact with magnetic nanoparticles (MNPs) was assessed for the first time with a microfluidic extensional approach, and used as an indicator of haematological disorders in comparison with a conventional haematological test, i.e. the haemolysis analysis. Microfluidic results highlight the potential of this microfluidic tool over traditional haemolysis analysis, by detecting small increments in the rigidity of the blood cells, when traditional haemotoxicology analysis showed no significant alteration (haemolysis rates lower than 2 %). The detected rigidity has been predicted to be due to the wrapping of small MNPs by the bilayer membrane of the RBCs, which is directly related to MNPs size, shape and composition. The proposed microfluidic tool adds a new dimension into the field of nanomedicine, allowing to be applied as a high-sensitivity technique capable of bringing a better understanding of the biological impact of nanoparticles developed for clinical applications.