Institution
University of Trás-os-Montes and Alto Douro
Education•Vila Real, Portugal•
About: University of Trás-os-Montes and Alto Douro is a education organization based out in Vila Real, Portugal. It is known for research contribution in the topics: Population & Context (language use). The organization has 2858 authors who have published 7146 publications receiving 138394 citations. The organization is also known as: University of Tras-os-Montes and Alto Douro & UTAD.
Topics: Population, Context (language use), Wine, Antibiotic resistance, Cancer
Papers published on a yearly basis
Papers
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TL;DR: In this article, solid lipid nanoparticles loaded with PZQ (PZQ-SLN) were prepared by a modified oil-in-water microemulsion method selecting stearic acid as lipid phase after solubility screening studies.
Abstract: Praziquantel (PZQ) is the drug of choice for oral treatment of schistosomiasis and other fluke infections that affect humans. Its low oral bioavailability demands the development of innovative strategies to overcome the first pass metabolism. In this article, solid lipid nanoparticles loaded with PZQ (PZQ-SLN) were prepared by a modified oil-in-water microemulsion method selecting stearic acid as lipid phase after solubility screening studies. The mean particle size (Z-Ave) and zeta potential (ZP) were 500 nm and −34.0 mV, respectively. Morphology and shape of PZQ-SLN were analysed by scanning electron microscopy revealing the presence of spherical particles with smooth surface. Differential scanning calorimetry suggested that SLN comprised a less ordered arrangement of crystals and the drug was molecularly dispersed in the lipid matrix. No supercooled melts were detected. The entrapment efficiency (EE) and loading capacity of PZQ, determined by high performance liquid chromatography, were 99.06 ± 0.3 and 17.48 ± 0.05, respectively. Effective incorporation of PZQ into the particles was confirmed by small angle X-ray scattering revealing the presence of a lipid lamellar structure. Stability parameters of PZQ-SLN stored at room temperature (25 °C) and at 4 °C were checked by analysing Z-Ave, ZP and the EE for a period of 60 days. Results showed a relatively long-term physical stability after storage at 4 °C, without drug expulsion.
45 citations
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TL;DR: In this article, computational fluid dynamics techniques were used to study the hydrodynamics of feed channels of a desalination membrane filled with spacers in zigzag arrangements and transverse in relation to flow.
45 citations
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TL;DR: The Bohemo-Iberian regional scale for South Gondwana, involving the Mediterranean Province, comprises five regional stages (Arenigian, Oretanian, Dobrotivian, Berounian and Kralodvorian) plus the global Tremadocian and Hirnantian as mentioned in this paper.
Abstract: The Bohemo-Iberian regional scale for South Gondwana, involving the ‘Mediterranean Province’, comprises five regional stages (Arenigian, Oretanian, Dobrotivian, Berounian and Kralodvorian) plus the global Tremadocian and Hirnantian. The predominance of shallow-water taxa in those high-latitude faunas imposes serious difficulties for correlating the regional succession with the formal global chronostratigraphy because of the almost total absence of the key graptolites and conodonts defining the base of the standard series, stages and stage slices. Instead, the abundant benthic faunas (trilobites, brachiopods, molluscs, echinoderms) of South Gondwanan origin largely dominated in the area from the middle Darriwilian to the late Katian. The poleward faunal migration of originally Avalonian, Baltic, Laurentian and even Asiatic taxa during the Boda Event of global warming progressively ends with the endemicity in the region, where the ensuing benthic assemblages were severely affected by the Hirnantian glaciation. The regional scale significantly improves the precision of correlations between Ordovician strata from SW and central Europe, North Africa and a large part of the Middle East. An updated record of palaeontological data from areas where Mediterranean faunas remain practically unknown, or are still poorly investigated, is also included. Palaeobiogeographical relationships based on the distribution of faunas across South Gondwana are suggested as an improvement for positioning many territories in modern palaeogeographical reconstructions and offer a constructive approach to problems related to the pre-Variscan and pre-Alpine orogenic puzzles.
45 citations
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TL;DR: In this paper, the reaction of methanol steam reforming was studied in a carbon membrane reactor over a commercial CuO/ZnO/Al 2 O 3 catalyst (SudChemie, G66 MR) carbon molecular sieve membranes supplied by Carbon Membranes Ltd were tested at 150°C and 200°C.
45 citations
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16 Sep 2019
TL;DR: In this article, the ionic liquid (IL) [Bmim][FeCl4] and poly(vinylidene fluoride) (PVDF) have been developed for humidity sensing applications.
Abstract: Polymer composites comprising the ionic liquid (IL) [Bmim][FeCl4] and poly(vinylidene fluoride) (PVDF) have been developed for humidity sensing applications. Different IL contents (5, 10, and 20 wt...
45 citations
Authors
Showing all 2911 results
Name | H-index | Papers | Citations |
---|---|---|---|
José A. Teixeira | 101 | 1414 | 47329 |
João Rocha | 93 | 1521 | 49472 |
Alcino J. Silva | 90 | 252 | 33508 |
Luís D. Carlos | 75 | 544 | 22063 |
Mikel Izquierdo | 71 | ||
Eliana B. Souto | 66 | 447 | 15706 |
Patrícia Valentão | 66 | 353 | 14645 |
Paul A. Kroon | 63 | 207 | 14502 |
J. A. Tenreiro Machado | 59 | 636 | 16757 |
Manuel A. Coimbra | 58 | 328 | 11108 |
João A. C. Santos | 56 | 305 | 10054 |
Adélio Mendes | 55 | 460 | 12913 |
Younes Messaddeq | 55 | 621 | 12792 |
José Alberto Pereira | 55 | 418 | 12191 |
Manuel Simões | 54 | 440 | 14380 |