Institution
VA Palo Alto Healthcare System
Healthcare•Palo Alto, California, United States•
About: VA Palo Alto Healthcare System is a healthcare organization based out in Palo Alto, California, United States. It is known for research contribution in the topics: Population & Health care. The organization has 2548 authors who have published 4605 publications receiving 209938 citations.
Topics: Population, Health care, Veterans Affairs, Poison control, Mental health
Papers published on a yearly basis
Papers
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TL;DR: The PC-based motion analysis offered a highly sensitive approach to identify characteristic whole body patterns of movement associated with pathological gait and may provide an improved basis for the development of interventions to modify knee load.
110 citations
TL;DR: Exposure to child abuse is associated with adult obesity among California women, even accounting for other relevant variables, and supports the notion that child abuse and its sequelae may be important targets for public health intervention, particularly in subpopulations where the prevalence of child Abuse is known to be high.
110 citations
TL;DR: Given the increasing prevalence of hypertension and the inability to achieve adequate BP control using traditional models of care, testing novel interventions in patients' homes may improve access, quality, and outcomes.
110 citations
TL;DR: Embryonic fibroblasts from Tgfb1-/- mice were stably transfected with a reporter plasmid consisting of TGF-β responsive Smad-binding elements coupled to a secreted alkaline phosphatase reporter gene (SBE-SEAP) and MFB-F11 cells can be used to rapidly and specifically measure TGF -β with high sensitivity.
Abstract: Transforming Growth Factor-β (TGF-β) regulates key biological processes during development and in adult tissues and has been implicated in many diseases. To study the biological functions of TGF-β, sensitive, specific, and convenient bioassays are necessary. Here we describe a new cell-based bioassay that fulfills these requirements. Embryonic fibroblasts from Tgfb1-/- mice were stably transfected with a reporter plasmid consisting of TGF-β responsive Smad-binding elements coupled to a secreted alkaline phosphatase reporter gene (SBE-SEAP). Clone MFB-F11 showed more than 1000-fold induction after stimulation with 1 ng/ml TGF-β1, and detected as little as 1 pg/ml TGF-β1. MFB-F11 cells were highly induced by TGF-β1, TGF-β2 and TGF-β3, but did not show induction with related family members activin, nodal, BMP-2 and BMP-6 or with trophic factors bFGF and BDNF. MFB-F11 cells can detect and quantify TGF-β in biological samples without prior enrichment of TGF-βs, and can detect biologically activated TGF-β in a cell co-culture system. MFB-F11 cells can be used to rapidly and specifically measure TGF-β with high sensitivity.
110 citations
TL;DR: The hypotheses that CRPS involves activation of the innate immune system, with keratinocyte and mast cell activation and proliferation, inflammatory mediator release, and pain are supported.
110 citations
Authors
Showing all 2575 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Gregg C. Fonarow | 161 | 1676 | 126516 |
| Jongmin Lee | 150 | 2257 | 134772 |
| Roger J. Davis | 147 | 498 | 103478 |
| Eugene C. Butcher | 146 | 446 | 72849 |
| Gerald M. Reaven | 133 | 799 | 80351 |
| Paul G. Shekelle | 132 | 601 | 101639 |
| Helena C. Kraemer | 132 | 562 | 65755 |
| Glenn M. Chertow | 128 | 764 | 82401 |
| Lawrence Steinman | 119 | 639 | 55583 |
| Rudolf H. Moos | 119 | 622 | 49816 |
| Cornelia M. Weyand | 116 | 460 | 44948 |
| Jiahuai Han | 111 | 379 | 49379 |
| Jörg J. Goronzy | 111 | 420 | 37634 |
| Adolf Pfefferbaum | 109 | 530 | 40358 |
| Michael F. Green | 106 | 485 | 45707 |