Institution
VA Palo Alto Healthcare System
Healthcare•Palo Alto, California, United States•
About: VA Palo Alto Healthcare System is a healthcare organization based out in Palo Alto, California, United States. It is known for research contribution in the topics: Population & Health care. The organization has 2548 authors who have published 4605 publications receiving 209938 citations.
Topics: Population, Health care, Veterans Affairs, Poison control, Mental health
Papers published on a yearly basis
Papers
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TL;DR: It is concluded that consistent gait differences exist between hemiparetic and non-disabled subjects walking at matched speeds, and the differences provide insights, concerning hemiperetic impairment and related compensatory strategies, that are in addition to the observation of slow walking speed.
607 citations
TL;DR: This work elucidate how energy produced by muscles is delivered to the crank through the synergistic action of other non-energy producing muscles; specifically, that a major function performed by a muscle arises from the instantaneous segmental accelerations and redistribution of segmental energy throughout the body caused by its force generation.
606 citations
University of Milan1, Leipzig University2, University of Antwerp3, Technische Universität München4, Katholieke Universiteit Leuven5, University of New Mexico6, Mayo Clinic7, Brigham and Women's Hospital8, Wake Forest University9, University of Queensland10, Pennington Biomedical Research Center11, VA Palo Alto Healthcare System12
TL;DR: The primary target audience of this position paper is clinicians who have limited orientation with CPX but whose caregiving would be enhanced by familiarity and application of this assessment, and a series of forms designed to highlight the utility of CPX in clinical decision-making.
Abstract: From an evidence-based perspective, cardiopulmonary exercise testing (CPX) is a well-supported assessment technique in both the United States (US) and Europe. The combination of standard exercise testing (ET) (ie, progressive exercise provocation in association with serial electrocardiograms [ECG], hemodynamics, oxygen saturation, and subjective symptoms) and measurement of ventilatory gas exchange amounts to a superior method to: 1) accurately quantify cardiorespiratory fitness (CRF), 2) delineate the physiologic system(s) underlying exercise responses, which can be applied as a means to identify the exercise-limiting pathophysiologic mechanism(s) and/or performance differences, and 3) formulate function-based prognostic stratification. Cardiopulmonary ET certainly carries an additional cost as well as competency requirements and is not an essential component of evaluation in all patient populations. However, there are several conditions of confirmed, suspected, or unknown etiology where the data gained from this form of ET is highly valuable in terms of clinical decision making.1
Several CPX statements have been published by well-respected organizations in both the US and Europe.1–5 Despite these prominent reports and the plethora of pertinent medical literature which they feature, underutilization of CPX persists. This discrepancy is at least partly attributable to the fact that the currently available CPX consensus statements are inherently complex and fail to convey succinct, clinically centered strategies to utilize CPX indices effectively. Likewise, current CPX software packages generate an overwhelming abundance of data, which to most clinicians are incomprehensible and abstract.
Ironically, in contrast to the protracted scientific statements and dense CPX data outputs, the list of CPX variables that have proven clinical application is concise and uncomplicated. Therefore, the goal of this writing group is to present an approach of CPX in a way that assists in making meaningful decisions regarding a patient’s care. Experts from the European Association for Cardiovascular Prevention and Rehabilitation and American Heart Association have joined in this effort to distill easy-to-follow guidance on CPX interpretation based upon current scientific evidence. This document also provides a series of forms that are designed to highlight the utility of CPX in clinical decision-making. Not only will this improve patient management, it will also catalyze uniform and unambiguous data interpretation across laboratories on an international level.
The primary target audience of this position paper is clinicians who have limited orientation with CPX but whose caregiving would be enhanced by familiarity and application of this assessment. The ultimate goal is to increase awareness of the value of CPX and to increase the number of healthcare professionals who are able to perform clinically meaningful CPX interpretation. Moreover, this document will hopefully lead to an increase in appropriate patient referrals to CPX with enhanced efficiencies in patient management. For more detailed information on CPX, including procedures for patient preparation, equipment calibration, and conducting the test, readers are encouraged to review other publications that address these and other topics in great detail.1–5
591 citations
TL;DR: It is demonstrated that the temporal balance between Notch and Wnt signaling orchestrates the precise progression of muscle precursor cells along the myogenic lineage pathway, through stages of proliferative expansion and then differentiation, during postnatal myogenesis.
586 citations
Vanderbilt University Medical Center1, Ohio State University2, The Ohio State University Wexner Medical Center3, Sutter Health4, University of California, San Francisco5, VA Palo Alto Healthcare System6, Stanford University7, Innovative Solutions & Support8, University of North Carolina at Chapel Hill9, Tufts Medical Center10, University of Chicago11, Houston Methodist Hospital12, Society of Critical Care Medicine13, Novant Health14, Saint Joseph Mercy Health System15, University of Pennsylvania16, Johns Hopkins University17
TL;DR: ABCDEF bundle performance showed significant and clinically meaningful improvements in outcomes including survival, mechanical ventilation use, coma, delirium, restraint-free care, ICU readmissions, and post-ICU discharge disposition.
Abstract: Objective:Decades-old, common ICU practices including deep sedation, immobilization, and limited family access are being challenged. We endeavoured to evaluate the relationship between ABCDEF bundle performance and patient-centered outcomes in critical care.Design:Prospective, multicenter, cohort st
571 citations
Authors
Showing all 2575 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Gregg C. Fonarow | 161 | 1676 | 126516 |
| Jongmin Lee | 150 | 2257 | 134772 |
| Roger J. Davis | 147 | 498 | 103478 |
| Eugene C. Butcher | 146 | 446 | 72849 |
| Gerald M. Reaven | 133 | 799 | 80351 |
| Paul G. Shekelle | 132 | 601 | 101639 |
| Helena C. Kraemer | 132 | 562 | 65755 |
| Glenn M. Chertow | 128 | 764 | 82401 |
| Lawrence Steinman | 119 | 639 | 55583 |
| Rudolf H. Moos | 119 | 622 | 49816 |
| Cornelia M. Weyand | 116 | 460 | 44948 |
| Jiahuai Han | 111 | 379 | 49379 |
| Jörg J. Goronzy | 111 | 420 | 37634 |
| Adolf Pfefferbaum | 109 | 530 | 40358 |
| Michael F. Green | 106 | 485 | 45707 |