Institution
VA Palo Alto Healthcare System
Healthcare•Palo Alto, California, United States•
About: VA Palo Alto Healthcare System is a healthcare organization based out in Palo Alto, California, United States. It is known for research contribution in the topics: Population & Health care. The organization has 2548 authors who have published 4605 publications receiving 209938 citations.
Topics: Population, Health care, Veterans Affairs, Poison control, Mental health
Papers published on a yearly basis
Papers
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VA Boston Healthcare System1, University of Cambridge2, University of California, Los Angeles3, Istituto Italiano di Tecnologia4, University of São Paulo5, Harvard University6, European Bioinformatics Institute7, Erasmus University Rotterdam8, Case Western Reserve University9, Veterans Health Administration10, University of Pennsylvania11, Boston University12, Uppsala University13, Charité14, University College London15, Imperial College London16, University of Utah17, University of Arizona18, Brigham and Women's Hospital19, Stanford University20, VA Palo Alto Healthcare System21, Duke University22, United States Department of Veterans Affairs23, Vanderbilt University24, Emory University25, Vanderbilt University Medical Center26
TL;DR: These findings prioritize trials of drugs targeting IFNAR2 and ACE2 for early management of COVID-19 and prioritise trials of drug repurposing based on transcriptomic and proteomic data based on approved drugs or in clinical phase of drug development.
Abstract: Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted Mendelian randomization (MR) analyses, deriving genetic instruments based on transcriptomic and proteomic data for 1,263 actionable proteins that are targeted by approved drugs or in clinical phase of drug development. Using summary statistics from the Host Genetics Initiative and the Million Veteran Program, we studied 7,554 patients hospitalized with COVID-19 and >1 million controls. We found significant Mendelian randomization results for three proteins (ACE2: P=1.6×10−6, IFNAR2: P=9.8×10−11, and IL-10RB: P=1.9×10−14) using cis-eQTL genetic instruments that also had strong evidence for colocalization with COVID-19 hospitalization. To disentangle the shared eQTL signal for IL10RB and IFNAR2, we conducted phenome-wide association scans and pathway enrichment analysis, which suggested that IFNAR2 is more likely to play a role in COVID-19 hospitalization. Our findings prioritize trials of drugs targeting IFNAR2 and ACE2 for early management of COVID-19.
66 citations
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TL;DR: CTM may add utility for lung cancer diagnosis during imaging evaluation using a sensitive detection platform to identify stage I non–small-cell lung cancer patients undergoing imaging evaluation.
66 citations
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TL;DR: It is demonstrated that patellar maltracking is more prevalent in PF pain subjects with patella alta compared to subjects with normal patell a height, and greater patellA height is shown inPF pain subjects compared to pain free subjects using four indices commonly used in clinics.
66 citations
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TL;DR: Together, changes in facets of mindfulness significantly explained post-treatment PTSD and depression severity (19-24% of variance) and changes in nonjudgmental acceptance explained unique variance in post- treatment depression severity.
Abstract: Though there has been a recent surge of interest in the relations between facets of mindfulness and Posttraumatic Stress Disorder (PTSD), there has been a dearth of empirical studies investigating the impact of changes in facets of mindfulness on PTSD treatment outcomes. The present study tested the prospective associations between pre- to post-treatment changes in facets of mindfulness and PTSD and depression severity at treatment discharge, among 48 military Veterans in residential PTSD treatment adhering to a cognitive-behavioral framework. Together, changes in facets of mindfulness significantly explained post-treatment PTSD and depression severity (19-24% of variance). Changes in acting with awareness explained unique variance in post-treatment PTSD severity and changes in nonjudgmental acceptance explained unique variance in post-treatment depression severity. These results remained significant after adjusting for shared variance with length of treatment stay.
66 citations
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TL;DR: Results suggest that SP-303 may be effective in reducing stool weight and frequency in patients with AIDS and diarrhea.
66 citations
Authors
Showing all 2575 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gregg C. Fonarow | 161 | 1676 | 126516 |
Jongmin Lee | 150 | 2257 | 134772 |
Roger J. Davis | 147 | 498 | 103478 |
Eugene C. Butcher | 146 | 446 | 72849 |
Gerald M. Reaven | 133 | 799 | 80351 |
Paul G. Shekelle | 132 | 601 | 101639 |
Helena C. Kraemer | 132 | 562 | 65755 |
Glenn M. Chertow | 128 | 764 | 82401 |
Lawrence Steinman | 119 | 639 | 55583 |
Rudolf H. Moos | 119 | 622 | 49816 |
Cornelia M. Weyand | 116 | 460 | 44948 |
Jiahuai Han | 111 | 379 | 49379 |
Jörg J. Goronzy | 111 | 420 | 37634 |
Adolf Pfefferbaum | 109 | 530 | 40358 |
Michael F. Green | 106 | 485 | 45707 |