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Institution

VA Palo Alto Healthcare System

HealthcarePalo Alto, California, United States
About: VA Palo Alto Healthcare System is a healthcare organization based out in Palo Alto, California, United States. It is known for research contribution in the topics: Population & Health care. The organization has 2548 authors who have published 4605 publications receiving 209938 citations.


Papers
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Journal ArticleDOI
TL;DR: It is shown that both costamerogenesis and myofibrillogenesis are initiated at sites of membrane contacts with the extracellular matrix and that their maturation is tightly coupled.

105 citations

Journal ArticleDOI
TL;DR: Current methods of determining the duration of post-traumatic amnesia, reports on neuropsychological deficits in PTA, reviews available data that allow inferences about its mechanism, and suggestions for further exploration of its pathophysiology are suggested.
Abstract: Post-traumatic amnesia (PTA) is a transient sequela of closed head injury (CHI). The term PTA has been in clinical use for over half a century, and generally refers to the subacute phase of recovery immediately after unconsciousness following CHI. The duration of PTA predicts functional outcome after CHI, but its pathophysiological mechanism is not known. This paper compares current methods of determining the duration of PTA, summarizes reports on neuropsychological deficits in PTA, reviews available data that allow inferences about its mechanism, and suggests methods for further exploration of its pathophysiology.

105 citations

Journal ArticleDOI
TL;DR: These results identify the chemokine receptors present on infiltrating lymphocytes during end-stage liver disease and suggest that such infiltration is predominantly controlled by non-tissue-specific inflammatory chemokines, a situation that may be distinct from liver homing pathways under normal conditions.

105 citations

Journal ArticleDOI
TL;DR: Of the eight behavioral pain scales developed for use in adult ICU patients, the Behavioral Pain Scale (BPS) and the Critical-Care Pain Observation Tool (CPOT) are considered to be the most valid and reliable for this purpose, according to the available evidence.
Abstract: A valid pain assessment is the foundation of adequate pain management Pain assessment can be challenging, especially in adult intensive care unit (ICU) patients who are unable to self-report In such situations, relying on observational assessment tools is an alternative strategy This review describes and analyzes the development and psychometric properties of pain assessment tools developed for use with nonverbal critically ill adults A total of 32 relevant papers that described the psychometric properties of eight pain assessment tools were included The scale development process, psychometric properties (ie, reliability and validity), and feasibility of pain assessment tools were analyzed using a 0 to 20 scoring system Each pain assessment tool was scored independently by two reviewers Of the eight behavioral pain scales developed for use in adult ICU patients, the Behavioral Pain Scale (BPS) and the Critical-Care Pain Observation Tool (CPOT) are considered to be the most valid and reliable for this purpose, according to the available evidence Behavioral pain scales may be viable alternatives to assessing pain in ICU patients who are unable to self-report, but only valid, reliable, and feasible scales should be used for this purpose

105 citations

Journal ArticleDOI
TL;DR: Loneliness and social isolation are strongly associated with several adverse health outcomes in older persons including death and functional impairments, and the strength of these associations has been compared with smoking.
Abstract: Loneliness and social isolation are strongly associated with several adverse health outcomes in older persons including death and functional impairments. The strength of these associations has been compared with smoking. Accordingly, loneliness and isolation have significant public health implications. Despite the adverse impacts of loneliness and social isolation on quality of life, and their strong association with health outcomes, the evaluation of loneliness and isolation have not been integrated into medical care. The risks for loneliness may be of particular concern to persons with serious illness as patients and caregivers cope with the experience of loss, loss of independence, and increasing care needs. To date, there has been no uniform way of evaluating and documenting loneliness and social isolation as a part of a review of a patient's social determinants of health. This article provides a framework for healthcare systems, providers, and community members working with older adults to (1) understand loneliness, isolation, and its counterpart social connection; (2) describe the different ways loneliness affects health; and (3) create a framework for asking about and documenting these experiences. Finally, because the lack of studies assessing whether targeting loneliness can improve health outcomes is a major gap, we provide guidance on the future of interventions. J Am Geriatr Soc 67:657-662, 2019.

105 citations


Authors

Showing all 2575 results

NameH-indexPapersCitations
Gregg C. Fonarow1611676126516
Jongmin Lee1502257134772
Roger J. Davis147498103478
Eugene C. Butcher14644672849
Gerald M. Reaven13379980351
Paul G. Shekelle132601101639
Helena C. Kraemer13256265755
Glenn M. Chertow12876482401
Lawrence Steinman11963955583
Rudolf H. Moos11962249816
Cornelia M. Weyand11646044948
Jiahuai Han11137949379
Jörg J. Goronzy11142037634
Adolf Pfefferbaum10953040358
Michael F. Green10648545707
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202316
202226
2021439
2020391
2019304
2018311