Juliana Barr

TL;DR: These guidelines provide a roadmap for developing integrated, evidence-based, and patient-centered protocols for preventing and treating pain, agitation, and delirium in critically ill patients.

TL;DR: Recommendations are presented that include endorsement of a shared decision-making model, early and repeated care conferencing to reduce family stress and improve consistency in communication, honoring culturally appropriate requests for truth-telling and informed refusal, spiritual support, staff education and debriefing to minimize the impact of family interactions on staff health.

TL;DR: ABCDEF bundle performance showed significant and clinically meaningful improvements in outcomes including survival, mechanical ventilation use, coma, delirium, restraint-free care, ICU readmissions, and post-ICU discharge disposition.

TL;DR: An evidence-based nutritional management protocol increased the likelihood that ICU patients would receive enteral nutrition, and shortened their duration of mechanical ventilation, and was associated with a reduced risk of death in those patients studied.

TL;DR: Compared to alfentanil, the high clearance of remifentanin, combined with its small steady-state distribution volume, results in a rapid decline in blood concentration after termination of an infusion, and the drugs are pharmacodynamically similar.