Showing papers in "Advanced Drug Delivery Reviews in 2023"

TL;DR: In this paper , the authors provide an overview of the progress and contemporary applications of nanocarriers in treating various eye diseases, highlighting their value in achieving efficient ocular drug delivery.

TL;DR: In this paper , the authors provide quantitative insights into the tissue distribution of nanoparticles and provide a critical overview of published nanoparticle physiologically-based pharmacokinetic (PBPK) models.

TL;DR: In this paper , the authors summarize recent advances in NIR-II-emitted nanoprobes for intravital multiplexed bioimaging and discuss the current challenges and potential opportunities in designing novel long-wavelength nanoprobs for deep-tissue intra-vivo-intravital multiconnection bio-imaging.

TL;DR: In this paper , a review of drug delivery systems (DDSs) for long-acting anticancer treatments is presented, highlighting recently proposed modifications and their potential advantages for different anticancer therapies.

TL;DR: A review of the current state of knowledge on circRNA structure and function can be found in this paper , where the authors outline recent techniques for synthesizing circRNAs, highlight key delivery strategies and applications and discuss the current challenges and future prospects in the field of circRNA-based therapeutics.

TL;DR: In this paper , a review summarizes known issues of protein corona and traditional strategies to control the corona, as well as emerging efforts to enhance drug delivery to target organs via nanoparticles.

TL;DR: In this article , the structural features of variable domains of heavy chain-only antibodies (VHHs) are discussed and a review of recent advances in using Nbs as a modular scaffold to facilitate the engineering of multivalent polymers for cutting-edge applications is presented.

TL;DR: The use of inorganic nanomaterials as scaffolds TMCs and the use of these bioorthogonal nanozymes in vitro and in vivo applications are discussed in this paper .

TL;DR: In this article , the authors provide a thorough overview of the most advanced image-guided approaches for bacterial diagnosis (e.g., computed tomography imaging, magnetic resonance imaging, photoacoustic imaging, ultrasound imaging, fluorescence imaging, positron emission tomography, single photon emission computed tomogram imaging, and multiple imaging).

TL;DR: In this paper , the authors provide an integrated material and biological perspective in terms of engineering stealth nanomaterials, and propose structural holism can be a watershed to improve the stealth effect; that is, the whole surface structure and geometry play important roles.

TL;DR: The authors in this paper reviewed different 3D preclinical models of the blood-brain barrier, both in health and disease, from their development to their application for permeability testing of nanomedicines across the BBB, discussing the advantages and disadvantages of each model.

TL;DR: In this paper , the authors discuss recent advances of stimuli-responsive biomaterials to regulate local microenvironments during wound healing, emphasizing on the design and application of different biommaterials which respond to wound biological/biochemical micro-environments (ROS, pH, enzymes, glucose and glutathione), physical micro environments (mechanical force, temperature, light, ultrasound, magnetic and electric field), and the combination modes.

TL;DR: Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug administration routes as discussed by the authors and can be used to provide sustained drug delivery for prolonged periods of time.

TL;DR: In this article , the authors summarized the recent advances regarding the utilization of nanotechnology in developing eye drops, and how to optimize the nanocarrier-based ocular drug delivery systems.

TL;DR: In this paper , the authors present a review of nine different types of nanocarriers and nineteen approaches that are described based on outcomes obtained from in vitro antimicrobial assays.

TL;DR: In this paper , the authors highlight the recent progress in the past five years on developing molecularly targeted nanomedicine for imaging detection and treatment of atherosclerosis with the use of inorganic nanoparticles.

TL;DR: In this paper , a review of different types of bacteria-based bioactive materials and their construction strategies were summarized, and the advantages and property-function relationship of the bacteria-biological materials were described.

TL;DR: In this article , a review on plasmonic nanoparticles and their assemblies for cancer radiotherapy is presented, focusing on the physicochemical properties of high-Z plasmoric nanomaterials and their ability to sensitize radiotherapy.

TL;DR: In this paper , the authors systematically review the recent progress of NIR-II imaging-guided drug delivery (IGDD) paradigms for the improvement of the prognosis of patients with tumors.

TL;DR: In this article , the authors provide an overview of the formulations being tested, the diseases they aim to treat, and the results observed from respective in vitro and in vivo studies, and discuss the advantages and disadvantages of these strategies, the remaining gaps of knowledge regarding their performance, and important items to consider for their clinical translation.

TL;DR: In this article , a comprehensive review of the sono-optogenetics method from the physical principles of ultrasound and mechanoluminescence to its emerging applications for unique neuroscience studies is presented.

TL;DR: In this article , a new computer-driven framework for rational pharmaceutical formulation design is proposed, inspired by the potential of in silico explorations in understanding drug delivery details and facilitating drug formulation design.

TL;DR: In this paper , a review summarizes the synthesis, chemical modifications, optical properties, and bio-imaging applications of semiconductor QDs with particular references to metal chalcogenide QDs and bimetallic CHDs and highlights the toxicity and pharmacokinetics of QD bioconjugates.

TL;DR: In this article , a review summarizes a variety of chemical and structural designs for constructing stimuli-responsive disintegrable nanoassemblies as well as their different disassembly routes, and discuss potential challenges and barriers towards clinical translation.

TL;DR: The use of long-acting parenteral formulations for the treatment of chronic infections such as HIV/AIDS and tuberculosis is a recent development in the field as discussed by the authors , which has the potential to improve the treatment for chronic conditions.

TL;DR: In this paper , the impact of inflammation and inflammatory mediators in tendon niches, unveiling the importance of tendon cell populations and their signature features, and the influence of microenvironmental factors on inflamed and injured tendons.

TL;DR: In this article , the authors summarize how host innate immune cells sense invading fungi through their pattern recognition receptors, and subsequently initiate a series of effector mechanisms and adaptive immune responses to mediate fungal clearance.

TL;DR: In this article , a review of microneedle-based strategies for modulating wound microenvironment via introducing the main characteristics of the wound micro environment and various types of MN-based delivery systems are also discussed.

TL;DR: In this paper , both viral and non-viral gene therapy delivery systems are emerging as promising alternatives or add-on therapies to traditional treatments for improving IOP control and providing neuroprotection.