Nanoparticle Biodistribution Coefficients: A Quantitative Approach for Understanding the Tissue Distribution of Nanoparticles.
TLDR
In this paper , the authors provide quantitative insights into the tissue distribution of nanoparticles and provide a critical overview of published nanoparticle physiologically-based pharmacokinetic (PBPK) models.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2023-01-19 and is currently open access. It has received 7 citations till now. The article focuses on the topics: Medicine & Biodistribution.read more
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Stealth and pseudo-stealth nanocarriers.
TL;DR: In this paper , the authors provide an integrated material and biological perspective in terms of engineering stealth nanomaterials, and propose structural holism can be a watershed to improve the stealth effect; that is, the whole surface structure and geometry play important roles.
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RNA-Seq-guided triple-combination nano-system of gold nanocluster, quercetin, and docetaxel for ultimate synergistic photothermal-chemotherapy against MDR tumor
TL;DR: In this paper , the authors used a gold nanocluster (GNC) micelle system capable of multiple NIR laser exposure; RNA-seq analysis revealed that repeated NIR exposure upregulates heat-shock protein and cell-cycle process related genes that could be associated with tumor recurrence.
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Peptide-Based Nanoparticles for Systemic Extrahepatic Delivery of Therapeutic Nucleotides
TL;DR: Peptide-based nanoparticles (PBN) for nucleotide complexation and targeting of extrahepatic diseases are gaining recognition as potent pharmaceutical vehicles for fine-tuned control of protein production (up-and/or down-regulation) and for gene delivery as mentioned in this paper .
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Bio-Responsive Macromolecular Drug and Small-Molecular Drug Conjugates: Nanoparticulate Prodrugs for Tumor Microenvironment Heterogeneity Management and Therapeutic Response Enhancement.
TL;DR: In this article , a practical solution on bio-responsive dual-drug conjugates for overcoming tumor microenvironment heterogeneity (TMH) and improving antitumor treatment, which integrates the advantages of macromolecular drugs and small-molecular drug, is proposed.
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Bacteria associated with glioma: a next wave in cancer treatment
TL;DR: A review of the previous years of research on bacteria-mediated glioma treatment can be found in this article , where the authors look back at the previous research and move forward to where they think it is headed.
References
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
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Monocyte and macrophage heterogeneity
Siamon Gordon,Philip R. Taylor +1 more
TL;DR: Recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues.
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Analysis of nanoparticle delivery to tumours
Stefan Wilhelm,Anthony J. Tavares,Qin Dai,Seiichi Ohta,Seiichi Ohta,Julie Audet,Harold F. Dvorak,Warren C. W. Chan +7 more
TL;DR: This Perspective explores and explains the fundamental dogma of nanoparticle delivery to tumours and answers two central questions: ‘ how many nanoparticles accumulate in a tumour?’ and ‘how does this number affect the clinical translation of nanomedicines?'
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PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
TL;DR: The history of the development of PEGylated nanoparticle formulations for systemic administration is described, including how factors such as PEG molecular weight, PEG surface density, nanoparticle core properties, and repeated administration impact circulation time.
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Gold nanoparticles in delivery applications
TL;DR: Gold nanoparticles provide non-toxic carriers for drug and gene delivery applications and their interaction with thiols is an effective and selective means of controlled intracellular release.