Showing papers in "Clinical Immunology and Immunopathology in 1989"

TL;DR: Increases in the number of HLA-DR+, CD38+ (OKT10), and Leu-8- CD8 lymphocytes were associated with a fall in CD4 levels and development of AIDS, and selective activation of subsets of CD 8 lymphocytes characterized disease progression.

TL;DR: The data demonstrate the abilities of IL-1 beta and TNF-alpha to induce IL-6 production in vivo and indicate that LPS induction ofIL-6 may be mediated, at least partially, through T NF-alpha action and suggest that IL- 6 may be an important effector in the manifestation of TNF -alpha and IL- 1 beta actions in vivo.

TL;DR: Article synthese sur la fonction des cellules NK au cours de certaines maladies humaines, dans le developpement de cancers ou de virose et leur activite chez des patients traites par chimiotherapie et radiotherapies.

TL;DR: It is suggested that TNF-α may retard murine lupus in B/W mice through effects on cellular rather than humoral mechanisms, and that the beneficial effects of T NF-α cannot be sustained indefinitely by chronic therapy.

TL;DR: Serum levels of interleukin 6 and acute phase proteins were measured in patients who underwent surgical operation, indicating that the measurement of serum IL-6 may be helpful for the early detection of an inflammatory state.

TL;DR: In studies of long-term nonprogressors - persons who have stable CD4+ T-cell counts and no HIV disease progression despite years of HIV infection - preserved lymph node architecture, low viral burden, and viral expression were found.

TL;DR: The data suggest that IL-1 and TNFα may be involved in the pathogenesis of HIV 1 infection.

TL;DR: High serum levels of soluble IL-2R correlated with several indices of disease activity in RA and SLE patients, as well as with disease progression to extraglandular involvement and to pseudolymphoma or lymphoma in patients with 1 degree SS.

TL;DR: Findings indicate that the valvular injury may at least in part be mediated by delayed-type hypersensitivity mechanisms.

TL;DR: It is demonstrated that IL-6 is released into synovial fluid in joints affected by arthritis, and there appears to be an association between the levels of IL- 6 and disease activity.

TL;DR: Within each class of FcR there appears to be considerable polymorphism, especially within the cytoplasmic portions, how these various structures dictate specific biological consequences is currently under study.

TL;DR: The demonstration that IL-4 is the essential factor for the induction of human IgE syntheses is demonstrated and further insight is provided into the cellular and molecular mechanisms involved in IgE regulation, as well as in the alterations responsible for IgE disregulation in some pathological conditions.

TL;DR: It is demonstrated that androgen therapy may reverse autoimmune sequelae in lacrimal, as well as submandibular, glands in a mouse model of Sjögren's syndrome.

TL;DR: An enzyme-linked immunosorbent assay (ELISA) using isolated 68K, A, B/B', and D polypeptides from purified U1 snRNP was developed, and levels of IgG antibodies were positively correlated with results of immunoblotting and hemagglutination.

TL;DR: Two monoclonal antibodies directed against the human progenitor cell antigen 1 (HPCA-1) (CD34) have been used for autologous positive stem cell selection in primates and these cells gave full hemopoietic reconstitution in the animals following lethal total body irradiation.

TL;DR: The analysis of specific histograms, questionnaires, and data analysis led to a specific set of recommendations for performance of flow cytometry studies.

TL;DR: An agent with a distinct and more favorable side effect profile might be useful in MG and intravenous immunoglobulin has such potential.

TL;DR: A subcommittee established by the National Committee for Clinical Laboratory Standards (NCCLS), composed of representatives from industry, academia, professional societies, and regulatory agencies, has drafted consensus procedures which address specific problems and suggested solutions for performance of immunophenotyping by flow cytometry.

TL;DR: It is shown that pulmonary granulomas were induced in mice by the intractracheal injection of agarose beads coupled to recombinant interleukin 1 (IL-1) or tumor necrosis factor-α (TNF-α).

TL;DR: Reactivity with HL-60 cells further elucidates the antigen specificity of both types of ANCA and indicates that HL- 60 cells are a suitable tissue culture cell line for investigating the pathobiology of AN CA.

TL;DR: This drug showed potential to prolong the lifespan, to reduce proteinuria, and to prevent the progression of nephropathy, andreciable differences in the levels of anti-dsDNA antibodies between treated and control animals were nil.

TL;DR: In sum, IVGG may be useful in treating specific IC renal diseases by solubilization of circulating or in situ ICs but definitive proof is lacking and in other situations, IV GG may exacerbate the glomerulonephritis, possibly through enhanced IC formation.

TL;DR: The findings that the IL-2,IL-2R, and IFN-gamma genes are not constitutionally defective in the elderly support the hypothesis that the age-related decline in proliferation observed in mitogen-stimulated T cells of the elderly is most likely attributable to alterations in the transmission of signals from the cell membrane to the nucleus.

TL;DR: It is hypothesized that MTg-specific Ts are present in normal, EAT-susceptible mice in low numbers to contribute to the maintenance of self-tolerance and that they are stimulated by increased levels of circulatory MTg to expand/differentiate and mediate the marked resistance to EAT induction.

TL;DR: A murine system in which treatment with recombinant human interleukin 1 (IL-1) induced an acute lethal state with pathologic changes similar to septic shock at high doses and development of arthritic and other tissue changes following more prolonged treatment with lower doses is described.

TL;DR: The effects of fish oil extracts and EPA on phagocytosis and humoral responses may be advantageously used in the therapy of chronic inflammatory diseases and autoimmune diseases but could be a cause for concern when these compounds are used for longer periods of time and with minimal medical supervision for the prophylaxis of atherosclerosis.

TL;DR: It was showed that cocaine had general suppressive effects on the mouse immune system and the size of tumors appeared to be increased in mice injected with cocaine for 10 consecutive days in comparison to the control mice.

TL;DR: In CCD patients under the age of 10, both anti-HIV-1 positive and negative, there were absolute elevations in immunocytes, including CD4, and there was also a distinctly different distribution of CD4 subsets.

TL;DR: The predominance of 2H4+ virgin T cells in the CD4 population whose function is associated with that of the induction of suppression rather than the up-regulation of immune responses may contribute to the observed susceptibility of neonates to infection.

TL;DR: The idiotype network concept needs to be revised in order to be in agreement with current data on protein/protein interactions, with the phenomenon of T and B cell recognition of idiotopes, and with the failure of certain anti-idiotypes to stimulate a given immune response.