Showing papers in "European Journal of Pharmacology in 1975"

TL;DR: The results indicate that yohimbine is more potent in blocking the presynaptic then the postsynaptic α-adrenoceptors of the artery.

TL;DR: Findings suggest that TRH may act both as a hormone, released into the portal vessels, as well as a neurotransmitter or modulator, released at synapses in discrete regions of the brain and spinal cord.

TL;DR: These experiments support the previous conclusion that local biosynthesis of a prostaglandin (induced by mild trauma) sensitizes pain receptors to mechanical or chemical stimuli.

TL;DR: It is concluded that tertiary antidepressants act on noradrenergic neurons in their unchanged form and not via secondary amine metabolites formed during the recording experiments since alterations in liver metabolism did not influence the response.

TL;DR: The present study aims at further identifying the interaction of ACTH-like peptides and rat brain opiate receptors in vitro and finds the sequence ACTH4-10 is crucial with respect to affinity since it is the shortest sequence to inhibit the binding of [ 3H]-dihydromorphine and [3H]-naltrexone to these receptors.

TL;DR: Three anticholinergic drugs, atropine, scopolamine and benztropine significantly reversed the effect of haloperidol on the acquisition of the nigroneostriatal projection and support the view that this system is critically involved in the acquistion of learned instrumental responses.

TL;DR: It is suggested that clonidine modulates morphine withdrawal signs by potentiating the behavior associated with heat dissipation and inhibiting the behavior related with heat gain mechanisms (precipitated shakes) and these effects may occur via stimulation of central noradrenergic mechanisms.

TL;DR: The intracerebral injection technique was used to apply dopamine directly into dopamine-containing areas of the mesolimbic system, the nucleus accumbens septi, tuberculum olfactorium and nucleus amygdaloideus centralis, causing consistent stereotyped sniffing and a dose-dependent hyperactivity.

TL;DR: This method was capable of detecting the analgesic activity of morphine-like and narcotic antagonist-type analgesics, as well as the activity of the antipyretic analgesics.

TL;DR: Cyclic 3',5'-adenosine monophosphate was a less effective depressant than various other adenine nucleotides, including cyclic 2',3'-adenoine monphosphate.

TL;DR: The effect of d-amphetamine on the release of tritiated norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) was analyzed in synaptosomes from different brain area and d-Amphetamine also seems capable of releasing 3H- 5-HT from serotoninergic terminals.

TL;DR: The prostaglandin synthesis inhibitor, indomethacin, blocks the "rebound contractions" which characteristically follow the inhibitory responses of the guinea-pig taenia coli to non-adrenergic, non-cholinergic (purinergic) nerves and to exogenously applied ATP, without affecting the responses to periaterial adrenergic nerves.

TL;DR: In this article, the authors compared l-deprenyl with clorgyline, an MAO A inhibitor, with regard to its inhibitory effect on the formation of three major catecholamine metabolites, homovanillic acid (HVA), dihydroxyphenylacetic acid (DOPAC), and 3-methoxy-4-hydroxymylglycol (MOPEG) in the rat brain in vivo.

TL;DR: The results suggest that not only under normal conditions but also after treatment with various types of drugs, dopamine metabolism as reflected by the HVA levels, is closely related in the different rat brain structures.

TL;DR: Findings indicate that the depletion of brain serotonin by 4-chloroamphetamine is initially reversible but that there is a gradual transition into an irreversible effect between 24 and 48 hr after 4- chloroamphetamine injection.

TL;DR: The degree of involvement of the different areas was shown to differ for apomorphine and (minus)-NPA, in particular the nucleus accumbens septi appeared more important for the action of (minus-NPA and the tuberculum olfactorium for apomorphicine.

TL;DR: SQ 11725 had no depressant effects on contractile force of isolated guinea pig atrial muscle at the largest bath concentration studied, whereas propranolol caused significant depression at a concentration of 1-10 mug/ml, and was more effective in inhibiting tachycardic responses to treadmill exercise in unanesthetized dogs.

TL;DR: It is suggested that sedation or sleep induction by adrenergic drugs cannot be explained exclusively by an action on central alpha-adrenoceptors, and that such an action may be involved in the modulation of PS.

TL;DR: Results substantiate the hypothesis that H2-receptors mediate the histamine-induced increase in rate and contractility, whereas H1-receptionors mediates the slowing of atrioventricular conduction.

TL;DR: It is suggested that activation of dopaminergic receptors can lead to a reduction in myoclonic responses to photic stimulation, and in baboons responded idiosyncratically to both haloperidol and pimozide, displaying intermittent dystonic episodes with bucco-facial dyskinesia.

TL;DR: One major difference was noted in that tricaine shifts sodium conductance curves in the direction of depolarization along the potential axis, an effect quite similar to that observed with increasing external Ca2+ concentration and with application of pentobarbital.

TL;DR: The thesis was advanced that dopamine neurons in the pars compacta of the substantia nigra also contained AChE, possibly to inactivate acetylcholine released from cholinergic fibers afferent to this neural structure.

TL;DR: It is concluded that DOPAC is the major dopamine metabolite in rat striatum and that its measurement may provide the best index of functional neuronal activity in this species.

TL;DR: 5-HT has possibly a role in the regulation of TSH secretion, since its precursor 5-HTP decreased the response to cold and alpha-methyl-p-tyrosine increased the TSH level, and the possibility of a dopaminergic inhibitory factor released from the hypothalamus is discussed.

TL;DR: The data support the existence of two distinct HA stores in the brain: depolarization relases the amine and increases its synthesis,probably in neurones, whereas compound 48/80 releases it from a slowly turning-over store, probably in mast-cells.

TL;DR: The relative elevation of the content of homovanillic acid was significantly greater in the striatum than in the olfactory tubercle for all drugs except thioridazine.

TL;DR: It was concluded that catecholamines have no essential transmitter functions in the cardiodepressor reflex loop and the action of clonidine on cardiovascular centers in the medulla is independent of endogenous noradrenaline storage and synthesis.

TL;DR: Observations suggest that the mesolimbic dopaminergic projections mediate some of the behavioral and visceral effects of d-amphetamine.

TL;DR: The microiontophoretic potencies of dopamine, apomorphine and alpha-aminobutyric acid were examined on caudate neurones in control animals and animals that had received 2mg/kg/day of haloperidol for 9 days, indicating the development of a post-synaptic supersensitivity.

TL;DR: The findings indicate that nomifensine specifically blocks the uptake mechanism for catecholamines in the brain without significant effects on serotonin.