Showing papers in "International Journal of Pharmaceutics in 1980"

TL;DR: The interplay of flow-rate, aqueous boundary layer and membrane permeability coefficients, solute lipophilicity and intestinal length has been quantitatively determined for the in situ situation of bulk fluid flow and concurrent steady-state absorption of steroids in the small intestines of the rat.

TL;DR: In this article, the rectal absorption of diazepam was studied in man and compared with intravenous, intramuscular and oral administration, and it was calculated that the drug will not exhibit measurable first pass metabolism.

TL;DR: The enhancement of the intestinal absorption by mixed micelles was mostly due to the alteration of the mucosal membrane permeability, while bile salt or saturated fatty acid mixed miceLLes caused small or no alterations of the permeability.

TL;DR: In this paper, the degree of percutaneous penetration to the thickness of the applied base has been derived and the relative importance of simple physicochemical parameters is discussed and theoretical release curves provided to show the way in which optimum dosage regimens may be achieved.

TL;DR: The effect of monoolein or oleic acid incorporated in micellar solution on the absorption inducement of heparin and the concomitant movement of these lipids suggest that lipids play a critical role in the improvement of absorption of macromolecules.

TL;DR: In this paper, the kinetics and mechanism of decomposition of the N 3 -hydroxymethyl derivatives of various hydantoins (phenytoin, nitrofurantoin and 5,5-dimethylhydantoin) in aqueous solution at 37°C was studied to assess their potential utility as prodrugs for the parent substances.

TL;DR: In this article, the authors compared dissolution rate data obtained with sulfathiazole-povidone (PVP) co-precipitates and hydrocortisone-pividone(HPCP) drug co-procedures with cellophane membrane diffusion data.

TL;DR: It has been demonstrated that 24 h after injection, adsorbed [ 3 H]actinomycin D is 5.6, 44, and 64-fold more concentrated than the free drug in muscle, spleen and liver respectively.

TL;DR: In this article, the temperature dependency of the n -octanol water partition coefficient and the hydrophobic substituent constant, π, for a series of substituted phenols has been determined.

TL;DR: Mathematical expressions have been derived to show the effect of metabolism within the epidermis and particular emphasis has been given to substances such as the corticosteroids which are known to form a reservoir in the skin.

TL;DR: The mechanism for the enhancement of the intestinal absorption of drugs in the presence of mixed micelles was investigated using liposomal membranes as a biomembrane model and the incorporation of monoolein into liposome membranes markedly increased the release rate of these drugs through the membranes.

TL;DR: In this paper, a reasonably realistic physical model has been described for the simultaneous longitudinal spreading, fluid flow and absorption of drugs in solution under non-steady state conditions m the small intestinal tract Various input cases included first-order and zero-order stomach emptying and input from an infinite drug reservoir at constant infusion rate

TL;DR: A particle growth due to moisture absorption did not appear to be important for the total drug deposition in the respiratory tract and differences in air flow rate and tidal volume did not affect the results.

TL;DR: In this paper, the effect of habit modification on the dissolution rate of NiSO 4 α6 H 2 O in 60% ethanol was studied using a rotating basket method using X-ray diffraction powder patterns for the three habits.

TL;DR: In this article, the solubility of a poorly water-soluble drug, diazepam, in different bile salt solutions and in mixed micellar solutions, liquid crystals and emulsions of various sodium cholatelecithin compositions were investigated.

TL;DR: In one case, the capsule lodged in the oesophagus and gradually emptied its contents into the stomach, whereas after food, the dispersion was more in keeping with the in vitro disintegration times.

TL;DR: The selectivity, reproducibility and demand of time of some pharmacopoeia-methods and reversed-phase HPLC were compared for the 3 penicillins; Superior is the HPLC; this technique is highly selective and one of the fastest and most precise methods.

TL;DR: It was found that addition of up to 0.2 M chloride does not noticeably decrease the rate of loss of cisplatin in biological fluids, but rapid freezing of the samples and storage at ⩽-10°C results in good stability of cisPlatin for limited periods.

TL;DR: In this paper, the applicability of the vibratory ball mill to fine powder mixing is investigated using two model 1:1000 binary systems of microfine salicylic acid sucrose and milled tolbutamide with lactose.

TL;DR: In this paper, the authors studied the kinetics of decomposition of various N-Mannich bases of salicylamide in aqueous solution at 37°C to assess their suitability as prodrugs for amino compounds.

TL;DR: In this article, the authors investigated the release of a readily water-soluble substance (sodium chloride) from a liquid paraffin phase to an underlying water phase as a function of particle size (10−50 μm) and concentration (up to 10% m/m).

TL;DR: In this article, the pH-solubility profiles of three pharmaceutical hydrochloride salts were determined in sodium acetate-hydrochloric acid buffer, in pH range from 1.0 to 3.0.

TL;DR: Microcapsules containing sulfamethizole were prepared by coacervation of carboxymethylethylcellulose, an enteric coating material, from ethyl acetate solution in the presence of polylactic acid to achieve sustained absorption following the administration of the microcapsules.