Showing papers in "Journal of Asian Natural Products Research in 2009"

TL;DR: A series of molecules with antifungal activity against different strains of fungus have been found in plants, which are of great importance to humans.

TL;DR: It is suggested that both apoptotic and autophagic mechanisms contribute to the curcumin-induced K562 cell death, which is associated with the formation of the apoptosome complex, the collapse of the mitochondrial membrane potential, and caspase-3 activation.

TL;DR: A new p-hydroxyphenylacetyl flavonoid, diosmetin 7-O-β-d-glucopyranoside (1), was isolated from the flowers of Chrysanthemum morifolium Ramat and its structure was elucidated by UV, IR, ESI-TOF-MS, 1D, and 2D NMR spectroscopic methods.

TL;DR: The studies suggest that berbamine exerts anticancer effects on human HCC HepG2 cells in vivo and in vitro, and the induction of p53 and the activity of the Fas apoptotic system may participate in the anticancer activity of berbamines in HepG 2 cells.

TL;DR: 1 may be a promising agent for AD, and the mechanism is related to β-secretase inhibition and protection against Aβ-induced cytotoxicity.

TL;DR: Four new guaiane-type sesquiterpenes (1S,4S,5S,10R)-zedoarondiol, zedoalactone D, E, and F (1–4) were isolated from Curcuma wenyujin and their inhibitory effects on nitric oxide production were evaluated.

TL;DR: A new homoisoflavonoid is isolated from the stems of Dracaena cambodianol and exhibited significant cytotoxic activities against K562 and SGC-7901 with the IC50 values of 1.4 and 2.9 μg/ml, respectively.

TL;DR: It is suggested that SML could be used as effective agents in the management of Huntington's disease by improving body weight, locomotor activity, motor coordination, and attenuated oxidative damage in different regions of rat brain.

TL;DR: This paper deals with the phytochemical investigation on Phyllanthus muellerianus and isolates 3–5 have been isolated and characterized for the first time from this source.

TL;DR: It is concluded that osthol would be an attractive natural compound for practical agronomic use against powdery mildew and may be associated with the direct fungitoxic property against the pathogen.

TL;DR: A new lignan rhamnoside, racemiside, has been isolated from the ethyl acetate-soluble fraction of Cotoneaster racemiflora, along with scopoletin, and all of them showed profound antioxidative activities in the DPPH assay.

TL;DR: It was found that FOj-5-S had significant action on the in vivo model compared with FOJ-5 (P < 0.05), and the obtained results indicated that only when the degree of substitution was in a certain range, the FOJ the5S had excellent anti-myocardial ischemic activity.

TL;DR: The present results suggest that xanthoceraside may provide a potential treatment strategy for Alzheimer's disease.

TL;DR: The results suggest that whole BV and melittin will be developed as a novel antibacterial drug.

TL;DR: The results suggest that isoflavonoids of Pueraria flowers may be of therapeutic potential in alcoholism related to microglial activation.

TL;DR: Five new compounds, dencryol A, Dencryol B, crystalltone, crystallinin, and 3-hydroxy-2-methoxy-5,6-dimethylbenzoic acid, together with six known compounds, have been isolated from the stems of Dendrobium crystallinum.

TL;DR: Two new phenolic constituents characterized as 3-methoxy-11-hydroxy-6,8-dimethylcarboxylate biphenyl and 3,5,6,7-tetrahydroxy-3′,4′-dimethoxyflavone-5-β-d-xylopyranoside are isolated from the seeds of Zanthoxylum alatum Roxb.

TL;DR: Two new annonaceous acetogenins named as squamostanin-A andSquamostAnin-B were isolated from 95% EtOH extract of the seeds of Annona squamosa by spectroscopic method and cytotoxicities were evaluated using MTT method.

TL;DR: Among the isolated compounds, clematoside S and α-hederin showed moderate cytotoxic activities against four human tumor cell lines with IC50 values in the range of 1.44–6.86 μg/ml.

TL;DR: The ethanolic extract of the plant as well as the isolated compounds 1–3 showed potent antimicrobial activity against two bacterial species (Staphylococcus aureus and Streptococcus mutans) and three fungus pathogens

TL;DR: A novel compound, selaginellin C (1), was isolated from Selaginella pulvinata Maxim as (R,S)-4-((1,2-dihydroxyethyl)-2′,4′-dhydroxy-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)((4-Hydroxyl)methylene)cyclohexa-2,5-dienone

TL;DR: The result indicated that a majority of triterpenoid saponins of this herb may be useful in the exploration of lead compounds for the treatment of some autoimmune diseases.

TL;DR: Three new minor dammarane saponins, quinquenosides L10, L14, and L16, were isolated from the leaves and stems of Panax quinquefolium L by the combination of one- and two-dimensional NMR techniques and MS spectroscopic analysis.

TL;DR: This new acetyl flavonol showed potent inhibitory activity against the production of NO in RAW264.7 stimulated by LPS with the IC50 value of 16.79 μM.

TL;DR: It is indicated that naturally occurring triterpenoid saponins can be regarded as excellent structures for the potential development of new anticancer agents.

TL;DR: A new naphthalene derivative, 1-methyl-2,3-methylenedioxy-6-naphthalenecarboxylic acid methyl ester, and a new alkaloid, ( ± )- 1-phenyl-2-imido-1-propanol, together with the four known compounds, ephedrine, pseudoephedrine

TL;DR: Two new secolignans are isolated from the whole grass of Selaginella sinensis (Desv.) Spring and their structures were elucidated by NMR and MS experiments.

TL;DR: Two new compounds were isolated from the EtOAc extract of the broth of the marine fungus Penicillium griseofulvum Y19-07 and showed potential activity against HL-60 and PC-3 prostate cancer cell lines and were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry.

TL;DR: Two new prenylated C6–C3 compounds, 4-epi-illicinone E-12-shikimate and 3-hydroxyillifunone B, were isolated from the fruits of Illicium simonsii and their structures were elucidated on the basis of extensive spectroscopic methods.

TL;DR: Two new depsidones, livistones A and B, and a new benzofurane,livistone C, together with the 11 known compounds including three stilbenes, exhibited remarkable cell protective activities against H2O2-induced SH-SY5Y cell damage.