Showing papers in "Journal of Critical Care in 1993"

TL;DR: The results indicate that the Sid gap, base excess gap, and anion gap reflect the presence of unmeasured ions, and both the anion-gap and base-excess gap provide readily available estimates of the SID gap.

TL;DR: Reperfusion hypotension seen in group 2 patients correlated only with a decrease in systemic vascular resistance, and acute hyperkalemia, hypothermia, and acidosis do not appear to be major causes of reperfusions hypotension.

TL;DR: To test the hypothesis that this effect of hemofiltration is caused by convective removal of factors that adversely affect hemodynamics during endotoxemia, ultrafiltrate from endotoxic shock pigs into healthy pigs was infused.

TL;DR: Application of CPAP in acute asthma reduces respiratory rate and dyspnea with no untoward effects on gas exchange, expiratory airflow, or hemodynamics, and these levels ofCPAP were tolerated without deleterious side effects.

TL;DR: Although local complications and systemic infection are important predisposing factors for MOSF, a host-dependent response to unknown specific or nonspecific factors may have a role in the pathogenesis of the syndrome in 25% of patients.

TL;DR: It has become clear that the presence of live bacteria is not requisite to the occurrence of sepsis; debris from damaged or lysed bacteria (predominantly cell wall components) alone is sufficient; this findings help explain why many patients with sepsi are never found to be bacteremic, and why bacterenmia is not required for the definition of SIRS.

TL;DR: It is found that Vrec with PEEP up to 14 cm H2O was in general rather small and was absent in two patients, and if end-inspiratory Pst, rs is high at ZEEP, there is little or no alveolar recruitment with PEP; and Vrec and EELV were slightly higher during stepwise deflation than stepwise inflation with PORN.

TL;DR: There is an inverse relationship between delta PCO2 and CI that has not been previously described and may be a marker of a low cardiac index.

TL;DR: It is concluded that VO2 is independent of QO2 in patients with septic shock and lactic acidosis, and the presence of ARDS was predictive of death in this cohort.

TL;DR: It is concluded that men are more likely than women to use justice in the resolution of moral dilemmas, such as the conflicts of interest in the allocation of limited critical care resources, but that if women do use, or are required by the social system to use, justice inThe resolution ofmoral dilemma, they do a better job of it than men.

TL;DR: It is concluded that in a porcine model under sterile and nonpyrogenic conditions, prolonged anesthesia does not increase plasma cytokine levels.

TL;DR: Therapeutic infusion of dopexamine during endotoxemia did not favor flow to any particular organ; redistribution of cardiac output changed little after administration of dopExamine, and its effects were not significantly different from those of dobutamine.

TL;DR: The increase in oxygen demand caused by chest physical therapy triggered an integrated physiological response that resulted in increased respiratory and cardiac performance, which in some ways resembles the response to exercise.

TL;DR: A tamponade model was used to study the relationship between oxygen uptake (VO2) and oxygen delivery (DO2) during successive, reversible decreases in blood flow in pentobarbital-anesthetized and mechanically ventilated dogs and found no significant difference in VO2 at DO2crit.

TL;DR: It is suggested that LV ejection can enhance SVrv and that this interaction is not appreciably altered by volume loading or the presence of an intact pericardium, which would suggest that mechanical coupling was not the primary factor determining systolic ventricular interdependence.

TL;DR: It was found that pretreatment with either clonazepam, diazepam, phenobarbital, or valproic acid increased the central nervous system thresholds to the theophylline-induced seizures, whereas phenytoin and magnesium sulphate did not attenuate the sensitivity of the brain to the stimulatory action of this widely used bronchodilator.

TL;DR: Findings lend support to the hypothesis that intramyocardial pH determines myocardial function independent of CO2 production by buffer therapy by indicating that end-diastolic length was inversely proportional to changes in strokes, and coronary blood flow varied directly with changes in coronary venous Pco2.

TL;DR: It is concluded that prophylactic administration of commercial IVIg at a dose of 400 mg/kg, although safe, had no effect on the incidence of secondary infections in children with severe head injuries.

TL;DR: Continuous veno-venous hemodiafiltration offers superior azotemia control and a safe approach to renal replacement therapy in critically ill patients and may be regarded as the treatment of choice in such patients.

TL;DR: In almost all patients PEEP reduced DO2 and therefore worsened O2 balance by either increasing O2 extraction ratio and approaching the critical threshold for supply dependency or dismissing DO2 from the range of non-supply dependency.

TL;DR: In the intensive care unit setting, hyperventilated patients with severe neurological injury can not be considered to be adequate controls in terms of Rrs and Raw, because hypocapnia induces an increase of Raw and consequently also in Rrs (= Raw+delta Rrs).

TL;DR: A laminated, pocket-sized card containing a series of questions to be asked by any physician confronted with termination-of-treatment decisions is developed, fostering a systematic approach.

TL;DR: To measure the arterial occlusion Pcap at different positive end-expiratory pressure (PEEP) levels and to compare it with Pw, anesthetized, paralyzed, supine, and mechanically ventilated dogs were instrumented with a Swan-Ganz balloon tip catheter for monitoring pulmonary arterial pressure (Pa), for measuring cardiac output (CO; thermodilution technique), and for performing the arterIAL occlusions.

TL;DR: It is concluded that the interpretation of blood lactate levels during circulatory shock can be biased due to a reduced lactate clearance in patients with impaired liver function, unrelated to the status of the relationship between oxygen delivery and consumption.

TL;DR: A broader understanding by physicians of patient needs and welfare is suggested, which requires an ambitious research agenda so that physicians will be able to learn how they can genuinely help critically ill patients and their families during times of illness.

TL;DR: Observations indicate that H2O2, a product of neutrophil oxidative metabolism, is capable of producing both morphologic changes as well as gas exchange alterations in the isolated, perfused liver.

TL;DR: Emphasis in medical training is laid on therapeutic approaches that prolong life at all costs, but therapeutic goals directed at maintaining human function need to be developed in parallel with global societal values regarding quality of life issues.

TL;DR: The very nature of critical care makes it inordinately difficult to objectively address any idea of rationing health care resources, and the ethical dilemmas created by the national belief that health care rationing is inevitable are matters of wide public concern.

TL;DR: It is suggested that isotonic Carbicarb may have more beneficial effects on cardiac function than hypertonic Carbcarb, and these effects may be related to associated changes in cytosolic sodium.