Showing papers in "Journal of Lipid Mediators and Cell Signalling in 1995"

TL;DR: In this model, cPLA2 is tightly regulated by multiple pathways, including those that control Ca2+ concentration, phosphorylation states and c PLA2 protein levels, to exert both rapid and prolonged effects on cellular processes, such as inflammation.

TL;DR: The chapter compares and contrasts the structural and kinetic properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and -2 and discusses the description of the interactions of the two isozymes with nonsteroidal anti-inflammatory drugs (NSAIDs).

TL;DR: The availability of the 15-PGDH cDNA will be a valuable tool for studying how this enzyme is regulated and isolation of the genomic DNA with its promoter regions has not yet been reported.

TL;DR: There is a physiological steady-state concentration of HNE in human venous blood plasma that is in the same range as the concentration that was found to inhibit the proliferation of cells of the peripheral tissues in vitro.

TL;DR: Establishment of PAFR(-/-) mice confirmed that the PAF receptor is responsible for pro-inflammatory responses, but that its roles in other settings remain to be clarified.

TL;DR: In this paper, a variety of organic and inorganic multi-valent cations were examined for their effects on the activity of purified PI-PLC δ and found that ionic complexes with phosphoinositides may alter their hydrolysis.

TL;DR: In this article, it has been attempted to review data primarily on the activation of human 5-lipoxygenase, in vitro and in the cell, using Ca2+, membranes, ATP, and lipid hydroperoxide.

TL;DR: Although the inhibition induced by BN-52021 suggests the involvement of PAF in cerulein-pancreatitis, the lack of effect of WEB-2170 reported here does not allow a definite conclusion and further studies are needed to elucidate the differential effect of the PAF antagonists.

TL;DR: The present results suggest that the lymphocyte growth suppressive effect of 20:5n-3 20:3n-6 or n-3 fatty acids is very likely to be independent on both the cAMP system and eicosanoid synthesis, and does not seem to involve their conversion to peroxidised products.

TL;DR: It is concluded thatPAF may be involved in the secretory effects of C. difficile toxin A, and that PAF antagonists deserve further study in C. Difficile diarrhea.

TL;DR: It is concluded that the endogenous leukotriene production can be reduced effectively by high doses of fish oil or vitamin E, whereas vitamin E depletion is associated with an increase in leukOTriene generation.

TL;DR: The present review is concerned with a group of prostanoids from soft corals, namely, clavulones and their congeners, as well as with related octadecanoids found in plants of the genus Chromolaena (Compositae).

TL;DR: Inhibition of phospholipase C reduced the supersensitivity to carbachol upon contractility in neonatal atria producing values similar to those of the adult atria, suggesting that muscarinic acetylcholine receptor (mAchR) stimulation is secondary to receptor-mediated hydrolysis of phosphoinositides.

TL;DR: It appears that inhibition of LT biosynthesis protects against both renal impairment and alterations in LTC4 synthase activity during the development of experimental GN, and may provide a useful therapeutic adjunct in the treatment of this disease.