Showing papers in "Journal of Pharmaceutical Sciences in 1966"

TL;DR: Fundamental mechanical and physicochemical properties of films as affected by plasticization, solvent effects, polymer chemistry, film additives, and other factors are considered in relation to film dissolution, permeability, and diffusion properties.

TL;DR: It was found that the choice of plastic, weight of drug incorporated in matrix, solubility of drug used, matrix additives, and solvent could markedly affect the release rate.

TL;DR: This report proposes that results previously attributed to eutectic mixtures are properly explained by the existence of solid solutions and a mechanism is considered by which such solid systems may enhance dissolution rates and, in turn, the gastrointestinal absorption rate and availability of poorly soluble drugs.

TL;DR: The release pattern obtained appears to follow the theoretical relationships previously proposed for solid drugs dispersed in solid matrices.

TL;DR: A direct correlation between surfactant activity and the rate of release has been found and it is proposed that these findings are consistent with an “encapsulated” drug particle model.

TL;DR: The pattern of blood level patterns indicated a redistribution into blood of I and II previously stored by tissues, and an apparent equilibrium was reached at a ratio of I–II of 1:2.5.

TL;DR: In this paper, the binary system of APAP and urea was found to be a simple eutectic mixture with negligible formation of solid solutions, and the presence of urea enhanced the dissolution rate by virtue of a microenvironmental solubilization.

TL;DR: In this paper, a differential extraction technique for the examination of the bark of the Australian plant Acronychia Baueri Schott ( Bauerella australiana Borzi), has resulted in the isolation of the triterpene lupeol and the alkaloids melicopine, acronycine, and normelicopidine.

TL;DR: The urinary recovery of rib oflavin as a function of dose after oral administration to fasted normal humans shows that the process responsible for the absorption of this vitamin is saturable, and the site specificity and saturability of riboflavin absorption suggest that the vitamin is absorbed by specialized transport rather than by passive diffusion.

TL;DR: The phase diagram for the griseofulvin and succinic acid system showed a eutectic mixture with considerable solid solubility of griseOfulvin in succinic acids.

TL;DR: The most salient feature of the toxicity of these compounds was the central depression on the animals and the rather low order of toxicity by the parenteral route of administration.

TL;DR: Solubility studies indicated that urea increased significantly the solubility of chloramphenicol; this resulted in a large increase in the initial dissolution rate of chlorampshenicol from physically mixed samples of the drug with urea.

TL;DR: In this article, it was found that tablets of plain microcrystalline cellulose will tend to soften and swell when exposed to humid conditions, but the effect is reversed upon the removal of increased humidities.

TL;DR: Data on the micellar solubilization of the poorly water-soluble drugs, griseofulvin, hexestrol, and glutethimide, in 0–0.6 M aqueous solutions of the sodium salts of cholic, desoxycholic, taurocholics, and glycocholic acids at 3 temperatures are presented.

TL;DR: A refined experimental procedure for quantitatively studying the various factors governing the rate of release of drug from plastic matrices is described, and the matrix tortuosity can now be quantitatively determined independently of the solid drug release rate data.

TL;DR: The new potent antitumor agent, 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), is most stable at pH 4.5 and in acid and in solutions above pH 7, it decomposes rapidly.

TL;DR: It was found that tablets prepared by compression of hydrophilic gums, excipients, and drug in specified ratios result in prolonged release of drug.

TL;DR: In this investigation, mathematical equations are derived that permit the calculation of doses and of release constants that will give a blood concentration versus time curve most closely approximating an “idealized” curve.

TL;DR: A fluorometric assay for metabolite D-M was developed which when used in conjunction with the Koechlin and D'Arconte fluorometric assays for chlordiazepoxide allowed for a specific determination of each compound in blood.

TL;DR: A mixed bile salt system was found to possess a significantly lower critical micelle concentration (CMC) than any of the individual bile salts previously studied, and a mechanism for the role of dietary lipids and bileSalt in the absorption of drugs is proposed.

TL;DR: The S-shaped nature of the amount released versus (time) 1/2 plots was studied, and it appears that this behavior was the result of the relatively slow release of air from the tablets.

TL;DR: Analyses of some of the complex systems most likely to be encountered show that the three experimental approaches may not always yield the same numerical result and that comparative studies with several techniques may yield valuable information concerning the natures of the complexes.

TL;DR: Several of the samples exhibited increasing viscosity as they were cooled and, at their solidification points, formed amorphous glasses rather than crystalline solids, and it is proposed that these glasses form because of a modified lattice structure built of dimethyl sulfoxide and water molecules.

TL;DR: In this article, the solubility of 21 steroids in water at 25° was determined and compared with previous data whenever available, and the results showed that 21 steroids are solubile in 25° water.