Journal ArticleDOI
Stereochemical Factors and Receptor Interactions Associated with Narcotic Analgesics
About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1966-09-01. It has received 82 citations till now.read more
Citations
More filters
Journal ArticleDOI
Opiate Receptor: Demonstration in Nervous Tissue
TL;DR: Tritiated naloxone, a powerful opiate antagonist, specifically binds to an opiate receptor of mammalian brain and guinea pig intestine that closely parallels their pharmacological potency.
Journal ArticleDOI
Mu Opioids and Their Receptors: Evolution of a Concept
TL;DR: Understanding of these morphine-like agents and their receptors has undergone an evolution in thinking over the past 35 years, which now reveals a complexity of the morphine- like agents andtheir receptors that had not been previously appreciated.
Journal ArticleDOI
Properties of Opiate-Receptor Binding in Rat Brain
TL;DR: Potencies of opiates and their antagonists in displacing [(3)H]naloxone binding parallel their pharmacological potencies.
Journal ArticleDOI
The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone.
TL;DR: The fumaramate methyl ester derivatives of naltrexone and oxymorphone were both found to be reversible agonists on the guinea pig ileal longitudinal muscle preparation but beta-FNA possessed on irreversible antagonistic effect against morphine whereas beta-FOA had no such capacity.
Journal ArticleDOI
The distribution of enkephalin immunoreactive fibers and terminals in the monkey central nervous system: An immunohistochemical study
Suzanne N. Haber,Robert Elde +1 more
TL;DR: Differences were observed in some areas including the hypoglossal nucleus, substantia nigra and in the region of the nucleus accumbens and olfactory area and the possible functional significance of enkephalin localization in regions related to regulation of pain, mood, and autonomic function is discussed.
References
More filters
Journal ArticleDOI
p-σ-π Analysis. A Method for the Correlation of Biological Activity and Chemical Structure
Corwin Hansch,Toshio Fujita +1 more
Journal ArticleDOI
Synthetic analgesics: stereochemical considerations.
A H Beckett,A F Casy +1 more
TL;DR: Active analgesics are shown to have structures which enable them to present similar surfaces to allow of their association with a proposed “analgesic receptor surface,” the essential features of which are described.
Journal ArticleDOI
Dolantin, ein neuartiges Spasmolytikum und Analgetikum
O. Eisleb,O. Schaumann +1 more
Journal ArticleDOI
Über eine neue Klasse von Verbindungen mit spasmolytischer und zentral analgetischer Wirksamkeit unter besonderer Berücksichtigung des 1-Methyl-4-phenyl-piperidin-4-carbonsäure-äthylesters (Dolantin)
TL;DR: In this paper, die pharmakologischen Eigenschaften einer sich von 4-Phenylpiperidin ableitenden Korperklasse beschrieben.