Showing papers in "Journal of the Neurological Sciences in 1993"

TL;DR: This scale may be of use in studies especially focussing on deep white matter pathology on MRI, because it provides more detailed information, with good intra- and inter-observer reliability, and in rating periventricular hyperintensities this scale yielded no advantage.

TL;DR: Among 708 cases aged 25-74 years at onset, the most common type was typical, sporadic amyotrophic lateral sclerosis (SporALS), and Familial ALS (FamALS) was diagnosed in 7%.

TL;DR: The existence of epidermal nerve fibers will necessitate changes in present theory of structure and function of peripheral sensation, and these nerves appear to have a three-dimensional territorial distribution in relationship to the skin's surface.

TL;DR: The data indicate that CAA is an important etiological factor of cerebellar hemorrhages, as well as lobar cerebral hemorrhage, in normotensive, aged patients.

TL;DR: The present findings favour a cortical origin for the TMS induced silent period, probably on the basis of intracortical inhibition, rather than peripheral inhibition of spinal motoneurones which is considered to be the basis for the silent period following peripheral nerve stimulation.

TL;DR: The present technique of TMS mapping allows the representation of individual hand muscles in the primary motor cortex to be reliably and reproducibly mapped and should prove useful for further studies of the physiology and pathophysiology of the motor cortex in man.

TL;DR: It is hypothesized that viable cells produce or concentrate growth factors which prevent the induction of these enzymes, whereas damaged cells cannot, and the possibility that macrophages may contribute to delayed neuronal death following ischemia is raised.

TL;DR: Comparison of ultrasound and histopathological findings indicates that muscle lipomatosis has a much greater impact on muscular echointensity than does muscle fibrosis.

TL;DR: Obesity and recent weight gain occurred more frequently in patients, and the extent of visual loss did not correlate with age at diagnosis, duration of symptoms, degree of obesity, use of oral contraceptive pills, cerebrospinal fluid opening pressure, steroid treatment, or recurrence.

TL;DR: The finding that BBE and FS shared common autoantibody suggests that autoimmune mechanism common to FS is likely in BBE, and that both conditions represent a distinct disease with a wide spectrum of symptoms that include ophthalmoplegia and ataxia.

TL;DR: It is demonstrated that muscle cell replication in mdx mice commences at about 3 weeks of age, is maximal at 4-8 weeks, but continues at lower levels until at least 44 weeks, whereas myogenic cell replication was both retarded and inhibited by irradiation.

TL;DR: In FCMD muscle, a significant reduction of laminin M (merosin; a striated muscle specific basal lamina-associated protein) is found with approximately 26% of levels seen in controls by quantitative immunofluorescence, which may implicate a primary or central role for the basalLamina in FC MD muscle.

TL;DR: The findings suggest that the increased accumulations of these small heat shock proteins appear to be part of reactive processes of glial cells and neurons under pathologic conditions.

TL;DR: Four cases of severe acute Guillain-Barré syndrome (GBS) characterized by severe axonal degeneration are presented, all of which had electrically inexcitable motor nerves as early as 4 days after onset.

TL;DR: This study lends support to earlier suggestions that circuits involving the inferior olivary nuclei in the medulla and the thalmus are involved in the generation of essential tremor.

TL;DR: In non-irradiated legs, the implanted normal mpc formed markedly fewer dystrophin-positive fibres than in the contralateral, irradiated muscle, and undertook little or no migration to adjacent muscles, which indicates that some of the injected mpc must have retained the ability to proliferate, to migrate into a neighbouring muscle and to differentiate into new muscle for a considerable period after the original cell implant.

TL;DR: The data indicate that some CFS patients have some organic problem manifesting itself on neuroimaging, but finding MR abnormalities should warn the physician that the patient's symptoms may be secondary to some other medical illness and not simply primary CFS.

TL;DR: The presence of nitric oxide synthase in spinal cord and dorsal root ganglia was investigated by immunohistochemistry using antibodies against the constitutive neuronal form of NOS, indicative of the involvement of Nitric oxide in different neural functions.

TL;DR: Increased VZV latency prevalence in nervous tissue of younger people without subsequent disease indicates sufficient immune surveillance, and if the latent trigeminal ganglion HSV-1 genome were the source of endogenously acquired encephalitis, the peak incidence of HSVEncephalitis in older subjects correlates with the findings.

TL;DR: The data suggest that, after 2 h of MCA occlusion, brain tissue progresses from isolated neuronal injury to infarct with a time course dependent on anatomical site; and astrocytic reactivity, expressed by GFAP staining, reflects the outcome of the ischemic injury.

TL;DR: Raised intracellular pH thus appears to be the most characteristic abnormality in dystrophin-deficient muscle, and recovery of PCr, Pi and ADP after exercise were not impaired, suggesting that mitochondrial function is normal.

TL;DR: The findings provide an explanation for the rapid onset of fatigue in paraplegic patients taking part in FES programmes since muscles deficient in type 1 fibres will be unable to maintain force for any length of time.

TL;DR: A highly significant correlation was demonstrated between the initial 7 p.m. cortisol levels and fasting blood glucose values in those with prestroke normoglycemia, suggesting that hyperglycemia during the acute phase of stroke is a stress response.

TL;DR: Data suggest a potential role for autoimmune mechanisms in the destruction and loss of motoneurons in ALS and T-lymphocytes and activated microglia have been identified within spinal cord gray matter and motor cortex.

TL;DR: In 6 patients with early-onset Parkinson's disease smoking reduced tremor, rigidity, bradykinesia, and gait disturbance including frozen gait, and relieved parkinsonian symptoms in the off-period.

TL;DR: The results suggest that in CSF CK-BB and NSE are useful prognostic indicators of hypoxic brain injury when measured 28-76 h after cardiac arrest whereas blood samples have no prognostic value.

TL;DR: The data support the contention that the involvement of pathways that are critical for a given cognitive process as well as the progression of the axonal degeneration and sclerosis seem to play important roles in the pathophysiology of cognitive dysfunction in MS.

TL;DR: Large focal myelin thickenings were found in nerve biopsies of affected persons, whether or not pressure palsies had occurred, and by using three electroneurographical parameters it was possible to discriminate between asymptomatic patients and unaffected relatives.

TL;DR: High intensity signals on T2-weighted images in the precentral and adjacent gyri, frontotemporal white matter and pyramidal tract as well as rarely in the globus pallidus and thalamus may play a critical role in the supranuclear ophthalmoplegia seen in ALS patients.

TL;DR: Functional imaging can help us understand the nature of the networks involved in performing different motor tasks, and can reveal how these networks malfunction in the presence of bradykinesia or parkinsonian tremor.