Showing papers in "Natural Product Reports in 2004"

TL;DR: A diverse array of secondary metabolites have been isolated and characterized from marine-derived fungi and the structures and biological activities of these metabolites are presented.

TL;DR: The effect of HupA and other cholinesterase inhibitors (anti-AD drugs) on acetylcholine esterase activity in the rat cortex and butylCholine esters activity are compared.

TL;DR: The activities described here show that there are many potential new classes of anti-staphylococcal agents which should undergo further cytotoxicity, microbial specificity and preclinical in vivo studies to assess their potential.

TL;DR: Marine natural products involved in biofouling and antifouling are described.

TL;DR: In this review, the present state of knowledge on all factors that affect bioavailability of GLS-HPs are critically evaluated, including liberation from the plant material, absorption from the digestive system, distribution around the body, metabolism and excretion.

TL;DR: The structure and catalytic activity of vanadium haloperoxidases is reviewed herein, including the importance of V-HPO-catalyzed bromination and cyclization of terpene substrates.

TL;DR: Salvia miltiorrhiza and other Chinese herbal medicines traditionally used for cardiovascular disorders contain potent antioxidant moieties in addition to their phenolic constituents, which are effective inhibitors of oxidative reactions mediated by the inflammatory oxidants, peroxynitrite,hypochlorous acid and hydroxyl radical as well as iron-dependent lipid peroxidation.

TL;DR: In this article, the structures, synthesis, biosynthesis, and bioactivity of a series of cytotoxic macrolides, named amphidinolides, isolated from symbiotic marine dinoflagellates of the genus Amphidinium which were separated from inside cells of marine flatworms.

TL;DR: A review of natural Diels-Alder type cycloadducts, synthetic efforts on the chemical feasibility of the biosynthetic diels-alder reaction and a brief history of studies on Diels−alderases are discussed in this article.

TL;DR: This review covers the recent marine chemical ecology literature for macroalgae, sponges, octocorals and other benthic invertebrates; 332 references are cited.

TL;DR: In this review the names, structures and occurrence of all new drimane and rearranged drimanes which have been published between January 1990 and January 2003 have been collected.

TL;DR: This review highlights scientific advances from 1999-2003 in the emerging field of molecular genetics of polyketide and nonribosomal peptide natural products isolated from marine organisms towards the development of marine secondary metabolites as a sustainable source of new drugs.

TL;DR: This review covers compounds with activity on African trypanosomes isolated from natural sources and is organized according to the structure of the etabolites (alkaloids, phenolic derivatives, quinones, terpenes and other metabolites).

TL;DR: This review highlights structural and biosynthetic work on a group of nitrogen-functionalised terpenes that are almost exclusively found in marine invertebrates and the animals that feed on them.

TL;DR: This review describes recent findings where this rule of co-linearity is broken, either by one module being bypassed (skipping) or through one modules being used for multiple chain extension events (stuttering).

TL;DR: Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteria and archaea, which suggests that the pathway is a strong candidate for the discovery of novel antibiotic and herbicidal compounds.

TL;DR: The review covers structures, chemical properties and synthesis of calystegines, and an emphasis is laid on the biosynthesis of the nortropane alkaloids and on the enzymes and genes that are involved.

TL;DR: In this review, the major milestones along the pathway of desaturase research will be highlighted from a bioorganic perspective.

TL;DR: This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates, using the Bugula neritina/Endobugula sertula association as a primary example.

TL;DR: The nature of these terpenoids are reviewed in this article together with some bioactivity data in an effort to highlight the rapid development in the field of phytochemistry of the Aristolochia species.

TL;DR: The mechanism of amine oxidation by flavoprotein enzymes is critically analysed through analysis of available experimental data, drawing on data from model reactions, kinetic and spectroscopic approaches, structural and mutagenesis studies.

TL;DR: This review outlines the recent developments in uncovering the enzymes and intermediates involved in fluorometabolite biosyntheses in the bacterium Streptomyces cattleya, with particular emphasis on the purification and characterisation of the fluorinase, the C-F bond forming enzyme which initiates the biosynthesis.

TL;DR: Advancements in the field of Computer-Assisted Structure Elucidation of Natural Products achieved in the past five years are discussed and the option to validate the result by an independent procedure, a high quality ab initio quantum mechanical calculation, is discussed.

TL;DR: Recent progress in structure activity relationships for analogues of amphimedine 2 and ascididemin 3 classes of pyridoacridines and correlates reported molecular mechanisms of action with biological activities are summarized.

TL;DR: The use of N-heterocyclic carbenes (NHCs) in organic synthesis has increased dramatically since the first report of a stable carbene by Arduengo in 1991 as mentioned in this paper.

TL;DR: An overview of the latest methods applied in directed evolution is given in the introduction, together with a range of approaches for the selection of variants of enzymes with desired catalytic properties.

TL;DR: This review covers advances/developments in the use of enzymes in synthetic mono-/oligo-saccharide chemistry published in the literature between January 2001 and June 2003.

TL;DR: This review covers the structures and biological activities of the multitudinous marine-derived natural products isolated from the marine flora and fauna of this nation and demonstrates the enormous variety of novel structures elaborated by these organisms.

TL;DR: The literature up to 2003 as discussed by the authors highlights selected instances of the formulation of biogenetic schemes which over the past half century have contributed to our current understanding of the biosynthesis of secondary metabolites.