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Showing papers in "Progress in Cardiovascular Diseases in 1974"


Journal ArticleDOI
TL;DR: Of all the risk factors considered, hypertension emerges as the most common, most potent, and most universal contributor to cardiovascular mortality.

408 citations


Journal ArticleDOI
TL;DR: The damaging effect of sympathetic catecholamines on the cardiovascular system is reviewed, and the recent data that suggests that intravascular platelet aggregation is of etiologic importance is reviewed.

267 citations


Journal ArticleDOI
TL;DR: In the patient with coronary heart disease, certain types of ventricular ectopic activity, although rare and sporadic in occurrence, can be the sole harbingers of sudden and unexpected death.

218 citations


Journal ArticleDOI
TL;DR: There are several reasons for interest in the maternal hemodynamic adjustments that accompany pregnancy, and an understanding of these reversible changes and the mechanisms regulating them will lead to increased knowledge concerning the physiology of the circulation and its control.

189 citations



Journal ArticleDOI
TL;DR: Holter electrocardiography is a valuable clinical adjunct in determining permissible levels of activity in patients with established heart disease and may be the earliest practical method of detecting the coronary prone patient, especially those subject to the risk of sudden death.

102 citations


Journal ArticleDOI
TL;DR: A diverse group of patients with somewhat similar syncopal episodes but without atrioventricular block has been described in the medical literature, and an interesting and therapeutically challenging subgroup includes those patients with paroxysmal tachycardia complicating the atria1 bradycardia.

97 citations


Journal ArticleDOI
TL;DR: The pathophysiologic consequences of venous obstruction can be quantitated accurately with a noninvasive technique that measures electric impedance in the lower leg following inflation and deflation of a pneumatic tourniquet around the thigh.

92 citations


Journal ArticleDOI
TL;DR: The patterns of infection in 91 patients who developed Candida endocarditis after cardiac surgery are analyzed and the risk of disregarding postoperative candidemia, and of waiting for re-examination of the patient’s records is analyzed.

90 citations


Journal ArticleDOI
TL;DR: Since the first attempts of surgical correction of intracardiac defects in the early 195Os, problems have changed substantially due to the introduction of extracorporeal circulation, the improvement in surgical techniques, the refinements in anesthesia, the availability of DC electroshock, the better physiological approach to arrhythmias, and a more effective pharmacologic treatment.

89 citations



Journal ArticleDOI
TL;DR: “’In this instance, the sympatheticneuron would play a permissive role in the development of hypertension,’”




Journal ArticleDOI
TL;DR: In some patients, the therapeutic approach with adrenergicinhibiting drugs is successful, and a hypotensive effect can be achieved with only a moderate disruption of the overall control function of the adrenergic nervous system, however, in others, either the desired vasodepressor effect is not achieved, or it is obtained only at the expense of an unacceptable degree of disruption of adrenergic function such that homeostatic control of the circulation is severely compromised.


Journal ArticleDOI
TL;DR: It seems that the renin-angiotensin system is the main vasoconstrictor system used by the body to support the sodium volume component to maintain or restore adequuate renal perfusion, in a transition from a sodium-volume to vasoconStrictor-maintained type of hypertension.

Journal ArticleDOI
TL;DR: The animal observations can be extrapolated to patients with pulmonary embolism in describing many of the acute responses—tachypnea, shallow breathing, elevation of the hemidiaphragm, and abnormal blood gaseous exchange.


Journal ArticleDOI
TL;DR: This term has been used erroneously to describe a variety of chronic organic brain syndromes occurring in hypertensive patients including residuals of cerebral hemorrhage or cerebral infarction, senile dementia, cortical atrophy, pseudbbulbar palsy, and others.

Journal ArticleDOI
TL;DR: All vascular changes in chronic hypertension can be explained in terms of an inappropriate interaction between a vasoconstrictor component (largely angiotensin) and a volume factor (determined by renal excretory capacity modulated by aldosterone).


Journal ArticleDOI
TL;DR: Improvements in the technique of venography have now reached a point where it can be relied upon as a reference standard for evaluating the accuracy of the new methods for detecting thrombi, and there is real hope that the new knowledge arising from the use of improved diagnostic tools will help considerably in establishing a rational approach to the management of deep vein thrombosis.

Journal ArticleDOI
TL;DR: The complex sequence of changes observed in acute hypertensive arterial disease can be attributed very simply to sudden overstretching of weaker zones or branches when arterial pressure rises high or quickly enough to outstrip reserves of muscular tone and work hypertrophy.

Journal ArticleDOI
TL;DR: The AV nodal Wenckebach phenomenon is a manifestation of the operation of a positive feedback mechanism that is displaced not only by changes in heart rate but also by variations in autonomic neural tone, electrolyte concentrations, and the levels of certain drugs.

Journal ArticleDOI
TL;DR: Thromboembolic disease in young women is discussed emphasizing that considering the large number of women who use oral contraceptives serious adverse reactions are infrequent and the pill is a safe effective means of birth control.


Journal ArticleDOI
TL;DR: Electroversion of cardiac dysrhythmias is an exciting advance, but much greater effort is needed to uncover basic mechanisms of cardiac rhythm disturbances, to develop more physiologic approaches to their treatment, and particularly to the maintenance of sinus rhythm thereafter.

Journal ArticleDOI
TL;DR: Pregnancy is usually well tolerated by patients with mild essential hypertension but can be associated with superimposed preeclampsia-eClampsia, abruptio placentae, and increased fetal mortality in patients with severe hypertension.