Institution
Saint Vincent Hospital
Healthcare•Worcester, Massachusetts, United States•
About: Saint Vincent Hospital is a healthcare organization based out in Worcester, Massachusetts, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 582 authors who have published 753 publications receiving 13289 citations.
Topics: Population, Cancer, Medicine, Health care, Pandemic
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that neuropsychological assessment is a useful indicator of cognitive functioning in athletes and that both history of multiple concussions and learning disability are associated with reduced cognitive performance.
Abstract: ContextDespite the high prevalence and potentially serious outcomes associated
with concussion in athletes, there is little systematic research examining
risk factors and short- and long-term outcomes.ObjectivesTo assess the relationship between concussion history and learning disability
(LD) and the association of these variables with neuropsychological performance
and to evaluate postconcussion recovery in a sample of college football players.Design, Setting, and ParticipantsA total of 393 athletes from 4 university football programs across the
United States received preseason baseline evaluations between May 1997 and
February 1999. Subjects who had subsequent football-related acute concussions
(n=16) underwent neuropsychological comparison with matched control athletes
from within the sample (n=10).Main Outcome MeasuresClinical interview, 8 neuropsychological measures, and concussion symptom
scale ratings at baseline and after concussion.ResultsOf the 393 players, 129 (34%) had experienced 1 previous concussion
and 79 (20%) had experienced 2 or more concussions. Multivariate analysis
of variance yielded significant main effects for both LD (P<.001) and concussion history (P=.009),
resulting in lowered baseline neuropsychological performance. A significant
interaction was found between LD and history of multiple concussions and LD
on 2 neuropsychological measures (Trail-Making Test, Form B [P=.007] and Symbol Digit Modalities Test [P=.009]),
indicating poorer performance for the group with LD and multiple concussions
compared with other groups. A discriminant function analysis using neuropsychological
testing of athletes 24 hours after acute in-season concussion compared with
controls resulted in an overall 89.5% correct classification rate.ConclusionsOur study suggests that neuropsychological assessment is a useful indicator
of cognitive functioning in athletes and that both history of multiple concussions
and LD are associated with reduced cognitive performance. These variables
may be detrimentally synergistic and should receive further study.
835 citations
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TL;DR: This review explains the manifestations of tamponade, including a presentation in which the diagnostic finding of pulsus paradoxus is absent, and variant forms, such as low-pressure tamp onade and regional tamponades.
Abstract: Acute cardiac tamponade is life threatening and requires prompt pericardial drainage. This review explains the manifestations of tamponade, including a presentation in which the diagnostic finding of pulsus paradoxus is absent, and variant forms, such as low-pressure tamponade and regional tamponade.
615 citations
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TL;DR: A brief description of the biochemistry of the mevalonate pathway is presented, together with a review of the current knowledge of the clinical and therapeutical implications of this fascinating and complex metabolic pathway.
502 citations
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Mayo Clinic1, University of Cincinnati2, Cleveland Clinic3, American Academy of Dermatology4, University of California, San Francisco5, Harvard University6, Yale University7, Oregon Health & Science University8, University of Miami9, University of Connecticut10, Saint Vincent Hospital11, University of Pennsylvania12, University of South Florida13, Tulane University14, Georgetown University15
TL;DR: The appropriate use criteria process synthesizes evidence-based medicine, clinical practice experience, and expert judgment to optimize the use of MMS for scenarios in which the expected clinical benefit is anticipated to be the greatest.
Abstract: The appropriate use criteria process synthesizes evidence-based medicine, clinical practice experience, and expert judgment. The American Academy of Dermatology in collaboration with the American College of Mohs Surgery, the American Society for Dermatologic Surgery Association, and the American Society for Mohs Surgery has developed appropriate use criteria for 270 scenarios for which Mohs micrographic surgery (MMS) is frequently considered based on tumor and patient characteristics. This document reflects the rating of appropriateness of MMS for each of these clinical scenarios by a ratings panel in a process based on the appropriateness method developed by the RAND Corp (Santa Monica, CA)/University of California–Los Angeles (RAND/UCLA). At the conclusion of the rating process, consensus was reached for all 270 (100%) scenarios by the Ratings Panel, with 200 (74.07%) deemed as appropriate, 24 (8.89%) as uncertain, and 46 (17.04%) as inappropriate. For the 69 basal cell carcinoma scenarios, 53 were deemed appropriate, 6 uncertain, and 10 inappropriate. For the 143 squamous cell carcinoma scenarios, 102 were deemed appropriate, 7 uncertain, and 34 inappropriate. For the 12 lentigo maligna and melanoma in situ scenarios, 10 were deemed appropriate, 2 uncertain, and 0 inappropriate. For the 46 rare cutaneous malignancies scenarios, 35 were deemed appropriate, 9 uncertain, and 2 inappropriate. These appropriate use criteria have the potential to impact health care delivery, reimbursement policy, and physician decision making on patient selection for MMS, and aim to optimize the use of MMS for scenarios in which the expected clinical benefit is anticipated to be the greatest. In addition, recognition of those scenarios rated as uncertain facilitates an understanding of areas that would benefit from further research. Each clinical scenario identified in this document is crafted for the average patient and not the exception. Thus, the ultimate decision regarding the appropriateness of MMS should be determined by the expertise and clinical experience of the physician.
398 citations
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TL;DR: Saccharin was considerably more potent as a promoting agent than was tryptophan, inducing higher incidences of bladder tumors and having a shorter latent period than was saccharin, who might act as tumor-promoting agents during bladder carcinogenesis.
Abstract: The existence of at least two stages in bladder carcinogenesis was evaluated in male Fischer rats using N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) fed for six weeks at a level of 0.2% of the diet as the initiator. Sodium saccharin and dl-tryptophan were fed at levels of 5 and 2% of the diet, respectively, as possible promoting chemicals, and they were fed either immediately after FANFT administration or after six weeks of FANFT plus six weeks of control diet. All surviving rats were killed at the end of two years. Both chemicals significantly increased the incidence of bladder tumors following FANFT feeding compared to six weeks of FANFT feeding followed by control diet, and the results were similar whether saccharin or tryptophan feeding was started immediately after FANFT feeding was concluded or after a six-week delay. Saccharin was considerably more potent as a promoting agent than was tryptophan, inducing higher incidences of bladder tumors and having a shorter latent period. Long-term administration of FANFT induced a 100% incidence of bladder cancer. Sequential epithelial changes were observed by scanning and transmission electron microscopy as well as by light microscopy. Pleomorphic microvilli were present on the superficial cells of all tumors examined and on the surface cells of hyperplastic bladder epithelium after six weeks of FANFT plus six weeks of saccharin, but not after six weeks of FANFT and six weeks of control diet. Rats fed only saccharin, tryptophan, or control diet did not have bladder tumors or pleomorphic microvilli on bladder epithelium. These data suggest that saccharin and tryptophan might act as tumor-promoting agents during bladder carcinogenesis.
287 citations
Authors
Showing all 586 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert J. Goldberg | 109 | 666 | 49143 |
Paul E. Marik | 89 | 621 | 32719 |
John Crown | 71 | 378 | 23374 |
Frederick A. Anderson | 69 | 221 | 23644 |
Yogesh C. Awasthi | 61 | 254 | 12304 |
Ronald S. Weinstein | 56 | 308 | 13207 |
David H. Spodick | 52 | 545 | 10528 |
Peter McCluskey | 46 | 340 | 7897 |
Joseph Alroy | 42 | 174 | 9142 |
Christian Rose | 41 | 203 | 6885 |
Robert A. Yood | 37 | 78 | 5332 |
Bonnie H. Weiner | 36 | 102 | 4508 |
C. William Hanke | 35 | 150 | 4148 |
Jayashri Aragam | 31 | 68 | 3314 |
Michael Grasso | 31 | 80 | 3222 |