Showing papers in "Radiotherapy and Oncology in 1995"

TL;DR: From November 1993 to August 1994, 55 patients with localized prostate carcinoma had three gold seeds placed in the prostate under transrectal ultrasound guidance prior to the start of radiotherapy in order to track prostate motion.

TL;DR: The two large organizations that initiate and coordinate multicenter clinical trials in Europe and in North America, the EORTC and the RTOG, have recently formed specific subcommittees or working groups to update their systems for assessing the late injury to normal tissues.

TL;DR: The cellular mechanism of radiation-induced fibrosis can be seen as a multicellular process involving various interacting cell systems in the target organ resulting in the fibrotic phenotype of the fibroblast/fibrocyte cell system.

TL;DR: In this article, the authors have presented a document that is now in the process of being endorsed by all National Scientific Societies of Radiotherapy and Medical Physics of the European countries.

TL;DR: A retrospective analysis of 965 patients with invasive cervix cancer treated by radiation therapy between 1976 and 1981 was performed, and FIGO stage was the most powerful prognostic factor followed by radiation dose and treatment duration.

TL;DR: In this article, the authors measured the percentage of apoptotic cells (apoptotic index or AI) in pre-therapy biopsies and found that increasing apoptosis was associated with poor prognosis.

TL;DR: Dose per fraction, association of the tumour with bone, and the volume of the horizontal ramus of the mandibula irradiated with a high dose were observed to be significant risk factors.

TL;DR: It is concluded that breast size is an important determinant of dose heterogeneity within the breast.

TL;DR: Between 1979 and 1990, 149 patients with non-metastatic thymomas were treated in ten French cancer centers and a worse DFS was predicted by mediastinal compression on presentation, absence of chemotherapy, young age, and stages III-IVA.

TL;DR: It is demonstrated that the biology-based approach produces lung plans that are superior to those produced when only dose-based objectives are used and that the objectives should also incorporate biology, perhaps in the form of biological indices.

TL;DR: The purpose of this Late Effects Normal Tissue (LENT) Conference will be to analyze the current scoring system for acute and late effects and develop a system which embodies simplicity of design and will result in accuracy of detail.

TL;DR: It is concluded that 15 Gy given in three fractions 2F/W is as effective as 30 Gy in ten fractions 5F/ W, but more convenient to the patient and of less cost to society.

TL;DR: An overall response parameter can be calculated prior to irradiation, which is predictive for the radiation-induced change in the overall pulmonary function, and possibly for the incidence of radiation pneumonitis, in this group of patients.

TL;DR: The results of this retrospective analysis suggest that, for some patients with this diagnosis, radiation to the involved node region alone is adequate, and no difference in survival, or cause-specific survival, was found between the two treatment groups.

TL;DR: Survition depends on the volume of the tumor and the presence of involved nodes; systematic groin dissection does not however seem advisable.

TL;DR: The purpose of this review is to extrapolate from the current published literature the type of response that of Leydig cells to radiation, and to identify the information available on dose-response for this effect.

TL;DR: 5 years of systematic measurements of the dose delivered to each patient undergoing radiotherapy treatment with photon beams are reported in order to detect any systematic error that may have escaped the different checks performed at each step of planning and calculation prior to the first treatment session.

TL;DR: It was concluded that it was not possible to obtain consistent translational setup deviations, due to rotations, but a further improvement of the setup accuracy is possible by using an off-line setup verification procedure.

TL;DR: Radiation of internal mammary chain after conservative surgery does not lead to an increase in clinically important skin or pulmonary complications and whether it prevents recurrences or new primaries of the opposite breast is too early to say because of the short follow-up time.

TL;DR: The study has shown that EPID can help reaching a high accuracy in patient treatment and confirms the need to implement daily verification procedures and to correct deviations in the treatment set-up.

TL;DR: Between December 1981 and December 1988, 329 consecutive patients with stage I and II breast cancers who underwent wide excision or quadrantectomy with or without axillary dissection were referred to radiotherapy.

TL;DR: It is suggested that prolonging overall time of radiotherapy has an effect on local control in T2 and T3 transitional cell carcinoma of the urinary bladder and patient selection bias leads to overestimation of LRFP3 for the split-course radiotherapy in retrospective studies.

TL;DR: A novel method of designing intensity modulated beams (IMBs) to achieve compensation in external beam radiotherapy of the breast, without the need for CT scans, suggests that the uncertainties in the method are significantly smaller than the improvement in dose uniformity produced.

TL;DR: This is a retrospective review of stages I and II low grade nodal non-Hodgkin's lymphoma seen at the Royal Marsden Hospital and treated with radiotherapy alone and found no significance in histology, stage or extent of radiotherapy field for the other variables.

TL;DR: These results should be considered in clinical practice when prescribing safety margins and adequate cut off doses for sparing critical organs in head and neck cancer.

TL;DR: This low alpha/beta ratio for damage to human lung after thoracic irradiation for Hodgkin's disease is consistent with late effects values from animals and humans, and illustrates the influence of large fraction sizes on the occurrence of late pulmonary complications.

TL;DR: It was observed that the rectal bleeding was controlled completely in 81% cases in median follow up of 11 months (range 6-17 months) and diversion colostomy could be avoided in all the cases.

TL;DR: It is concluded that a local recurrence must be avoided due to the morbidity associated with local failure and the potentially low likelihood of curative treatment of a local Recurrence.

TL;DR: A significant negative influence of treatment interruption was seen in glottic cancer, and a trend toward significance in node-negative supraglottic Cancer is seen in univariate analysis.