Showing papers in "Seminars in Oncology in 1997"

TL;DR: This review presents current information on cytogenetic findings in AML, and correlations between karyotype and clinical features and outcome of de novo AML.

TL;DR: Antiangiogenesis agents and strategies differ from the usual cancer therapeutic approaches; therefore, investigators must devise new paradigms for the clinical development of agents that may only have a static effect on tumors and require prolonged, chronic administration.

TL;DR: Soft tissue sarcoma (STS) accounts for approximately 1% of all cancers diagnosed annually in the United States, and population-based data from Connecticut covering the years 1935-1989 have shown an increasing incidence of STS in both genders, with a greater increase among men than women.

TL;DR: Social stress, psychological distress, and psychosocial support effect the adjustment of breast cancer patients, influence their experience of and adherence to medical treatment, and may effect the course of the disease.

TL;DR: Each of the IFN-alpha species exhibits a different pattern of receptor interactions that reflects their different biologic activities and will likely explain the existence of this large family of IFN -alpha species,IFN-beta, and IFn-omega that all interact with the same basal receptor.

TL;DR: The goals of this brief review are to review folate homeostasis, to highlight the similarities and differences between natural folate and antifolates with respect to biochemistry and metabolism, and to present the pharmacology of methotrexate and several next-generation folate analogues, such as trimetrexates and raltritrexed, with an emphasis on mechanisms of drug resistance.

TL;DR: Although much is known about risk for treatment-related leukemias in adults, environmental, occupational, and other risk factors are less well studied.

TL;DR: Phase I trials demonstrate that pharmacokinetics are schedule dependent and that, in general, gemcitabine is well tolerated and dose-limiting toxicities are primarily myelosuppression.

TL;DR: This review addresses several approaches to improving the prognosis for patients with breast cancer in which understanding of tumor dynamics plays an important role and suggests that a consistent number of tumor cells remain whether high-dose chemotherapy with autologous bone marrow support is used in patients in complete pathologic remission or in patients with overt relapse.

TL;DR: Important highlights are the encouraging results using magnetic resonance imaging for noninvasive thermometry and the publication of several positive phase III trials for thermoradiotherapy compared to radiotherapy alone.

TL;DR: R reverse transcription polymerase chain reaction of the PML-RAR alpha rearrangement is useful for the monitoring of minimal residual disease and should be prevented in patients that relapse and become resistant to ATRA.

TL;DR: It is concluded that gemcitabine is a promising radiation sensitizer that needs to be developed cautiously if excessive normal tissue toxicity is to be avoided.

TL;DR: The search for novel antitumor agents from natural sources continues with botanists, marine biologists, and microbiologists teaming up with chemists, pharmacologists, toxicologists, and clinicians in the investigation of coral reefs, rain forests, and deep subsurface thermal vents for novel bioactive compounds.

TL;DR: The cancer cachexia syndrome is clinically characterized by anorexia, wasting, weight loss, weakness, fatigue, poor performance status, and impaired immune function, which are unresolved by forced caloric intake.

TL;DR: Current trends are largely due to earlier diagnosis, mammographic screening in developed countries, a decrease in deaths in both the United States and the United Kingdom, and an increasing proportion of deaths in developing countries.

TL;DR: Clinical trials of tamoxifen in ovarian cancer, hepatocellular carcinoma, desmoid tumors, malignant glioma, pancreatic carcinomas, melanoma, and renal cell carcinoma are reviewed.

TL;DR: Gemcitabine is active and well tolerated in elderly patients with NSCLC, and is a promising new alternative for the treatment of this patient population.

TL;DR: The continued progress in the understanding of the biology of neoplasia and in the identification, cloning, and sequencing of genes critical to tumor cell function permits the exploitation of this information to develop specific agents that may directly modulate the function of these genes or their protein products.

TL;DR: In conclusion, gemcitabine is an attractive drug to combine with a wide range of anticancer drugs; synergism is often schedule dependent.

TL;DR: Patients and family members should be human leukocyte antigen (HLA)-typed soon after the diagnosis to expedite transplantation should induction therapy fail, and results with unrelated donor transplants have improved with time and are approaching those for matched sibling transplants.

TL;DR: The history of the purification of human leukocyte IFN and key aspects of the current state of knowledge ofhuman leukocytes IFN genes and proteins are reviewed.

TL;DR: To identify new successful induction treatments in AML, more precise measures of CR are required including an attempt to define cytogenetic CR and molecular CR wherever it can be applied.

TL;DR: There is a very small, if any, association of tamoxifen and endometrial cancer, and in the asymptomatic patient on tamoxIFen, routine yearly gynecologic examinations are recommended.

TL;DR: The implication is that the investigators must understand the fundamental biology of the estrogen receptor complex in a tissue context before one can predict tissue activity of tamoxifen.

TL;DR: The series reported show that the patients who develop second NSCLCs tend to have early-stage NSCLC (predominantly stage I and II) and the survival of patients after the second resection of lung cancer is similar to that of patients presenting with initial NSCLS.

TL;DR: Observations support the notion that AML is heterogeneous at the molecular level, and suggest that clinicians will need to continue to take cytogenetic and molecular characteristics into consideration to optimize patient therapy.

TL;DR: The combination of carbogen breathing with MTH was far more potent than carbogen Breathing or MTH alone in increasing tumor oxygenation and potentiating the radiation effect in FSall tumors.

TL;DR: These seemingly disparate areas of research are attempted to integrate so that they can be more effectively used together to address the problem of secondary AML.

TL;DR: This article reviews the associations of cancer with rheumatic diseases and the effect of immunomodulating drugs in the development of malignancy.