Showing papers in "Virologica Sinica in 2020"

TL;DR: The use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury and should be combined with systemic anti-inflammatory drugs or corticosteroids.

TL;DR: In conclusion, the novel visual RT-LAMP assay is a simple, rapid, and sensitive approach for detection of SARS-CoV-2, and it is ready for application in primary care and community hospitals or health care centers, and even patients' own houses in response to the current Sars-Cov-2 epidemic because the assay does not require sophisticated equipment and skilled personnel.

TL;DR: The findings demonstrate the NTPase and helicase activities of SARS-CoV-2 nsp13, which may play an important role in Sars-Cov-2 replication and serve as a target for antivirals.

TL;DR: The sequence analysis on the S protein of 2019-nCoV has predicted a novel furin cleavage site at S1/S2 linkage, suggesting the ubiquitous expression of furin in different organs and tissues may be a reason for the high transmissibility and pathogenicity of the virus observed in the current epidemic.

TL;DR: Because there are no SARS-CoV cases reported since 2004, the aptamer-based method can be used as a supplementation to the current diagnosis of SARS -CoV-2.

TL;DR: This perspective is intended to stimulate discussions about possible pathogenic mechanisms, based on the interaction of the virus with its receptor ACE2, so that rational therapies can be developed and whether some of these potential treatments can be effective or beneficial in the management of 2019-nCoV-induced lung injury.

TL;DR: This paper suggests renaming 2019-nCoV as “transmissible acute respiratory syndrome coronavirus (TARS-CoV” and briefly review the advancement of research and development of neutralizing antibodies and vaccines targeting the receptor-binding domain (RBD) and viral fusion inhibitors targeting the heptad repeat 1 (HR1) domain in spike protein of 2019- nCoV.

TL;DR: This retrospective study investigated the clinical characterizes of the patients coinfected with SARS-CoV-2 and HBV by analyzing the clinical records and laboratory tests of 123 COVID-19 patients admitted to Zhongnan Hospital of Wuhan University,Wuhan, China, from January 5 to February 20, 2020.

TL;DR: During a retrospective study of recent pneumonia patients in the authors' department, two patients who are likely being infected with the 2019-nCoV are found and appropriately treated, and both were discharged within two weeks.

TL;DR: There is an urgent need for antiviral treatment in fighting the emerging viral diseases, and the development of antiviral drugs is time- and resource-consuming, and thus repurposing of existing drugs to treat Emerging viral diseases represents one of efficient strategies for drug development.

TL;DR: There is an urgent need for an ideal animal model that can reflect clinical symptoms and underlying etiopathogenesis similar to COVID-19 patients which can be further used for evaluation of underlying mechanisms, potential vaccines, and therapeutic strategies.

TL;DR: It is imperative to closely monitor laboratory parameters including the WBC count, LYMPH count, and CRP, along with other imaging features in chest CT scans, to promptly prevent, diagnose, and treat a SARS-CoV-2 infection during pregnancy.

TL;DR: Higher viral loads and stronger antibody responses are related to more severe disease status in patients with SARS-CoV-2 infection, and the antibodies persisted in the recovered patient for more than 6 months so that the vaccine may provide protection against SARS.

TL;DR: It appears that most efficient strategy of eliminating biofilms involves phages or lysins in combination with antibiotics, but the optimal scheme of their administration requires further studies.

TL;DR: The results suggest that more molecular epidemiological studies should be performed on several enteroviruses simultaneously, and such information should have implications for virological surveillance, disease management, vaccine development and policy-making on the prevention and control of HFMD.

TL;DR: Clues are provided for further understanding of Leflunomide as a potential antiviral drug against COVID-19 and a significant reduction in C-reactive protein levels indicate that immunopathological inflammation was well controlled.

TL;DR: By analyzing the secondary structures of the SARS-CoV-2 genome, several 21~25 base-long segments were obtained and selected as the potential targets of small interfering RNA duplexes and it was found that these targets are conserved among different strains.

TL;DR: This integrated 2D CR and 3D organoid cultures provide a physiological ex vivo model to study kidney functions, innate immune response of kidney cells to viruses, and a novel platform for drug discovery and safety evaluation.

TL;DR: Children with COVID-19 displayed an immunophenotype that is less inflammatory than adults, including unremarkable cytokine elevation, moderate CD4+ T cell response and inactive CD8+‬T cell responded, but their humoral immunity against SARS-CoV-2 were as strong as adults.

TL;DR: It is concluded that IgG could be a sensitive indicator for retrospective diagnosis and contact tracing, while IgM could be an indicator of early infection in COVID-19 infection.

TL;DR: In this study, the in vitro inhibitory activity of griffithsin (GRFT) against infection of pseudotyped and live SARS-CoV-2 infection is tested in order to repurpose the application of GRFT as a potential prophylactic or therapeutic to prevent or treat COVID-19.

TL;DR: The aim of this review is to bring together all the discovered information about the emerging pathogen human Aichi virus (AiV), discussing the possibles routes of transmission, new detection techniques and future research.

TL;DR: Comparison between patients with different disease severity suggested early seroconversion and high antibody titer were linked with less severe clinical symptoms, and supported the combination of serologic testing and NAT in routine COVID-19 diagnosis and provided evidence on the temporal profile of antibody response in patients withDifferent disease severity.

TL;DR: This paper reviews the current model analysis methods and conclusions from both micro and macro perspectives and concludes that the establishment of a comprehensive assessment model, and the use of model analysis prediction, is very efficient for the early warning of infectious diseases.

TL;DR: It is demonstrated that false negativity accounted for a vast majority of contradicting results in SARS-CoV-2 RNA test by RT-PCR.

TL;DR: Recently, several SADSr-CoVs in R. affinis which are closely related to the epidemic strains in pigs are identified which provide further evidences that SADS-CoV remains a serious threat to swine and closely related viruses are still circulating in these bat populations.

TL;DR: In this paper, the cause of viral clearance delay and the infectivity in COVID-19 patients with SARS-CoV-2 infection for more than 50 days post initial symptoms (PIS).

TL;DR: Wang et al. as discussed by the authors reviewed 51 detection kits for SARS-CoV-2 nucleic acids (24 kits), antibodies (25 kits), or antigens (2 kits) through November 20, 2020.

TL;DR: Lopinavir/ritonavir should be stopped for clinical use due to the huge gap between in vitro IC50 and free plasma concentration, and the structure–activity relationship analysis of the four inhibitors provided further information for novel design of future viral protease inhibitors of SARS-CoV-2.

TL;DR: This study increases the understanding of the genetic diversity of beta-CoVs and delta-CoV, and also provides a new perspective of the coronavirus hosts.