Dynamic Changes of Antibodies to SARS-CoV-2 in COVID-19 Patients at Early Stage of Outbreak.
Huaqing Shu,Shuzhen Wang,Shunan Ruan,Yaxin Wang,Jiancheng Zhang,Yin Yuan,Hong Liu,Hong Liu,Yongran Wu,Yongran Wu,Ruiting Li,Shangwen Pan,Yaqi Ouyang,Shiying Yuan,Shiying Yuan,Peng Zhou,You Shang,You Shang +17 more
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TLDR
It is concluded that IgG could be a sensitive indicator for retrospective diagnosis and contact tracing, while IgM could be an indicator of early infection in COVID-19 infection.About:
This article is published in Virologica Sinica.The article was published on 2020-07-27 and is currently open access. It has received 33 citations till now. The article focuses on the topics: Seroconversion & Serology.read more
Citations
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic.
Kelvin K. W. To,Siddharth Sridhar,Kelvin Hei-Yeung Chiu,Derek L.L. Hung,Xin Li,Ivan Hung,Anthony Raymond Tam,Tom Wai-Hin Chung,Jasper Fuk-Woo Chan,Anna Jian-Xia Zhang,Anna Jian-Xia Zhang,Vincent C.C. Cheng,Kwok-Yung Yuen +12 more
TL;DR: In this article, the authors reviewed representative publications on the epidemiology, virology, clinical manifestations, pathology, laboratory diagnostics, treatment, vaccination, and infection control of COVID-19 as of 20 January 2021, which is 1 year after person-to-person transmission of SARS-CoV-2 was announced.
Journal ArticleDOI
Antibody Response After SARS-CoV-2 Infection and Implications for Immunity : A Rapid Living Review.
Irina Arkhipova-Jenkins,Mark Helfand,Charlotte Armstrong,Emily Gean,Joanna Anderson,Robin Paynter,Katherine Mackey +6 more
TL;DR: In this paper, the authors synthesize evidence on the prevalence, levels, and durability of detectable antibodies after SARS-CoV-2 infection and whether antibodies to SARS co-v-2 confer natural immunity.
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Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment.
Norma A. Valdez-Cruz,Enrique García-Hernández,Clara Espitia,Laura Cobos-Marín,Claudia Altamirano,Carlos G. Bando-Campos,Luis Fernando Cofas-Vargas,Enrique Wenceslao Coronado-Aceves,Ricardo A. González-Hernández,Pablo Hernández-Peralta,Daniel Juárez-López,Paola A. Ortega-Portilla,Sara Restrepo-Pineda,Patricio Zelada-Cordero,Mauricio A. Trujillo-Roldán +14 more
TL;DR: In this article, the authors summarized the present understanding of the immune response and physiopathology caused by SARS-CoV-2, including the activation of the humoral immune response, and discussed about the antibodies that can be generated in COVID-19 convalescent sera.
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Reciprocating-flowing on-a-chip enables ultra-fast immunobinding for multiplexed rapid ELISA detection of SARS-CoV-2 antibody.
Yiren Liu,Yayin Tan,Quanying Fu,Maoren Lin,Jinxu He,Suhua He,Mei Yang,Shoudeng Chen,Jianhua Zhou +8 more
TL;DR: In this article, a reciprocating-flowing immunobinding (RF-immunobinding) strategy was proposed to detect SARS-CoV-2 antibodies within 60 s. This strategy was further developed into an immunoassay method for serological detection of 13 suspected COVID-19 patients.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.