Journal ArticleDOI
195 Pt–31P nuclear spin coupling constants and the nature of the trans-effect in platinum complexes
TLDR
In this paper, the s-component of the platinum-phosphorus bonds is analyzed in terms of the trans-effect of the ligand to weaken the bond trans to itself and its relation to the trans effect is considered.Abstract:
The 195Pt–31P nuclear spin coupling constants, ranging between 1462 and 5698 c./sec., of twenty-five platinum complexes are reported and discussed in terms of the s-component of the platinum–phosphorus bonds. The trans-influence is defined as the tendency of a ligand to weaken the bond trans to itself, and its relation to the trans-effect is considered. It is shown that the high trans-influence of phosphorus is probably due to a σ-bonding mechanism and makes a significant contribution to the high trans-effect of phosphorus ligands. Some 31P chemical shifts are reported.read more
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Journal ArticleDOI
The trans-influence: its measurement and significance
Journal ArticleDOI
Trans-effects in octahedral transition metal complexes
TL;DR: An extensive survey of structural trans-effects in octahedral d-transition metal complexes is presented in this article, which allows the identification of general STE classes into which the majority of common STE ligands fit.
Journal ArticleDOI
Metal Ion Modeling Using Classical Mechanics
Pengfei Li,Kenneth M. Merz +1 more
TL;DR: This Review focuses on classical metal ion modeling based on unpolarized models (including the nonbonded, bonded, cationic dummy atom, and combined models), polarizable models, and valence bond-based models.
Journal ArticleDOI
Trans influence of Boryl Ligands and Comparison with C, Si, and Sn Ligands
TL;DR: The trans influence of boryl ligands has been investigated theoretically via density functional theory (DFT) calculations on a series of square-planar platinum(II) complexes of the form trans-[PtL(Cl)(PMe3)2].
Journal ArticleDOI
The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators
Markus Follmann,Nils Griebenow,Michael G. Hahn,Ingo Hartung,Franz-Josef Mais,Joachim Mittendorf,Martina Schäfer,Hartmut Schirok,Johannes-Peter Stasch,Friederike Stoll,Alexander Straub +10 more
TL;DR: Two classes of compounds have been discovered that amplify the function of sGC in a NO-independent manner, the so-called sGC stimulators and sGC activators, the most advanced of which, the sGC stimulator riociguat, has successfully undergone Phase III clinical trials for different forms of pulmonary hypertension.