Journal ArticleDOI
3-Substituted-3-hydroxy-2-oxindole, an Emerging New Scaffold for Drug Discovery with Potential Anti-Cancer and other Biological Activities
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This article is published in Current Bioactive Compounds.The article was published on 2009-02-28. It has received 413 citations till now. The article focuses on the topics: Drug discovery.read more
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Journal ArticleDOI
Chiral Heterogeneous Scandium Lewis Acid Catalysts for Continuous-Flow Enantioselective Friedel–Crafts Carbon–Carbon Bond-Forming Reactions
Yuki Saito,Shū Kobayashi +1 more
TL;DR: In this paper, the first example of chiral heterogeneous Sc catalysts, which demonstrated excellent activity and selectivity for continuous flow enantioselective Friedel-Crafts reactions of isatins with indoles, was developed.
Journal ArticleDOI
Facile Synthesis of 3‐Hydroxy Oxindole by a Decarboxylative Aldol Reaction of β‐Ketoacid and Isatin in WERSA
Journal ArticleDOI
Journey Heading towards Enantioselective Synthesis Assisted by Organocatalysis.
TL;DR: This personal account summarizes the design of various organocatalysts derived from amino acids and Cinchona alkaloids and their applications in enantioselective carbon-carbon and carbon-nitrogen bond formation reactions.
Journal ArticleDOI
Rhodium-Catalyzed Enantioselective Addition of Arylboroxines to Isatin-Derived N-Boc Ketimines Using Chiral Phosphite-Olefin Ligands: Asymmetric Synthesis of 3-Aryl-3-amino-2-oxindoles.
TL;DR: An efficient rhodium-catalyzed enantioselective arylation of isatin-derived N-Boc ketimines with arylboroxines has been developed using H8-BINOL-derived phosphite-olefin as a chiral ligand, allowing access to a broad variety of valuable tetrasubstituted 3-amino-2-oxindole derivatives.
Book ChapterDOI
Chapter One – Oxindoles
TL;DR: The fundamental properties of oxindoles, including syntheses, electrophilic substitutions, and ring expansions, as well as alkylations of anions of Oxindole, are described.
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Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C‐3 Position
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