Journal ArticleDOI
3-Substituted-3-hydroxy-2-oxindole, an Emerging New Scaffold for Drug Discovery with Potential Anti-Cancer and other Biological Activities
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This article is published in Current Bioactive Compounds.The article was published on 2009-02-28. It has received 413 citations till now. The article focuses on the topics: Drug discovery.read more
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Organocatalyzed Enantioselective Decarboxylative Stereoablation Reaction for the Construction of 3,3′-Disubstituted Oxindoles Using β-Ketoacids and 3-Halooxindoles
TL;DR: The first asymmetric reaction between β-ketoacids and 3-halooxindoles utilizing an organocatalyst is described, which allows for the formation of a variety of 3,3'-disubstituted oxindoles bearing a keto-carbonyl group.
Journal ArticleDOI
Organocatalytic enantioselective cross-aldol reactions of aldehydes with isatins: formation of two contiguous quaternary centered 3-substituted 3-hydroxyindol-2-ones
Journal ArticleDOI
Enantioselective organocatalytic aldol reaction of unactivated ketones with isatins
TL;DR: Using this protocol, functionalized 3-alkyl-3-hydroxyindolin-2-ones can be accessed in high yields with good to excellent enantioselectivities.
Journal ArticleDOI
A Facile Pathway to Enantiomerically Enriched 3‐Hydroxy‐2‐Oxindoles: Asymmetric Intramolecular Arylation of α‐Keto Amides Catalyzed by a Palladium–DifluorPhos Complex
TL;DR: The method is applicable to aryl triflates bearing different aromatic and aliphatic substituents, as well as sterically hindered β-keto amide (XII) as mentioned in this paper.
Journal ArticleDOI
Regiospecific epoxide opening: a facile approach for the synthesis of 3-hydroxy-3-aminomethylindolin-2-one derivatives
TL;DR: In this article, a mild and eco-friendly method was developed for aminolysis of 3-oxirane-indolin-2-ones with aliphatic and aromatic amines.
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