Book ChapterDOI
4.16 – Isoxazoles and their Benzo Derivatives
S.A. Lang,Y.-I. Lin +1 more
- Vol. 4, pp 1-130
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The article was published on 1984-01-01. It has received 58 citations till now.read more
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Journal ArticleDOI
The coordination chemistry of platinum anticancer drugs and related compounds with DNA
TL;DR: This chapter discusses Pt-DNA interactions, which led to the discovery of metaIIointercaIation, and the role of cis-DDP and intercaIators on DNA in the development of platinum antitumor drugs.
Journal ArticleDOI
First heterogeneously palladium-catalysed fully selective C3-arylation of free NH-indoles
TL;DR: In this article, a simple heterogeneously palladium-catalysed procedure for the selective C3-arylation of indoles is reported. But this procedure requires the indoles substituted or not at position 2.
Journal ArticleDOI
Versatility of Weinreb amides in the Knorr pyrrole synthesis
TL;DR: In this paper, N -Methoxy-N -methyl-α-enaminocarboxamides were prepared starting from enamines and Weinreb α-aminoamides, and their reaction with oganometallic compounds and subsequent cyclization constitute a versatile alternative in the Knorr pyrrole synthesis.
Journal ArticleDOI
Haloacetylated enol ethers. 7 . Synthesis of 3-aryl-5-trihalomethylisoxazoles and 3-aryl-5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles†
TL;DR: In this paper, the 3-aryl-5-hydroxy 5-trihalomethylisoxazoles 5,6a-g was obtained by cyclocondesation with hydroxylamine hydrochloride in the presence of an excess of concentrated hydrochloric acid.
Journal ArticleDOI
Ultrasound promoted synthesis of 5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles and β-enamino trihalomethyl ketones in water
Marcos A. P. Martins,Claudio M. P. Pereira,Wilson Cunico,Sidnei Moura,Fernanda A. Rosa,Rodrigo L. Peres,Pablo Machado,Nilo Zanatta,Helio G. Bonacorso +8 more
TL;DR: A convenient method for the preparation of 5-hydroxy-5-trihalo-4,5-dihydroisoxazoles and beta-enamino trihalomethyl ketones from the reaction of 1,1,1-triHalo- 4-alkoxy-3-alken-2-ones with hydroxylamine and anilines using water as solvent and under ultrasound irradiation is reported.
References
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Journal ArticleDOI
1,3-Dipolar cycloadditions. 76. Concerted nature of 1,3-dipolar cycloadditions and the question of diradical intermediates
Journal ArticleDOI
Kinetik und Mechanismus 1.3‐Dipolarer Cycloadditionen
TL;DR: In this paper, mechanistische Kriterien fur die zu funfgliedrigen Ringen fuhrende 1.3-Dipolare Cycloaddition dienen die Stereoselektivitat bei Verwendung cis-trans-isomerer Dipolarophile, die Einflusse von Losungsmittel and Substituenten auf die Reaktionsgeschwindigkeitskonstanten, die Aktivierungsparameter and die Orientierung'sphan
Journal ArticleDOI
Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds.
TL;DR: Structural‐activity studies led to the findings that nipecotic acid (piperidine‐3‐carboxylic acid) is a powerful non‐competitive inhibitor of GABA uptake, and that perhydro‐1,2‐oxazine‐6‐car boxylic Acid is a relatively weak competitive inhibitor ofGA uptake.