Journal ArticleDOI
4'-Demethyl-epipodophyllotoxin thenylidene glucoside (VM 26), a podophyllum compound with a new mechanism of action.
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TLDR
The new podophyllotoxin glucoside derivative VM 26 was found to have a high cytostatic activity in cell cultures and inhibits entry of cells into mitosis or destroys cells preparing for mitosis, one of its biochemical effects is inhibition of thymidine uptake.About:
This article is published in European Journal of Cancer.The article was published on 1970-08-01. It has received 129 citations till now. The article focuses on the topics: Podophyllum.read more
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Biological activities of lignans
W.Donald MacRae,G.H.Neil Towers +1 more
TL;DR: This review summarizes what is presently known about the biological activities of lignans and specifically inhibit certain enzymes in angiosperms and gymnosperms.
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Topoisomerase-targeting antitumor drugs.
Peter D'Arpa,Leroy-Fong Liu +1 more
TL;DR: The identification of both topoisomersase I and II as the specific targets of cancer chemotherapeutic drugs now provides a rational basis for the development of topoisomerase I poisons for possible clinical use and may lead to the identification of new therapies for treating cancer.
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The Clinical Pharmacology of Etoposide and Teniposide
P I Clark,Maurice L. Slevin +1 more
TL;DR: Etoposide has been shown to be a highly schedule-dependent drug in clinical studies and there is no evidence of accumulation of etoposide and teniposide after multiple consecutive doses by the intravenous or oral routes.
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Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship.
TL;DR: In this article, 14 congeners of podophyllotoxin were evaluated for their ability to induce DNA breakage and inhibit growth of A549 human lung adenocarcinoma cells.
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Intravesical and Systemic Chemotherapy of Murine Bladder Cancer
TL;DR: It is hoped that information gained from these animal models, which allow evaluation of many drugs within a relatively short period of time, will identify drugs effective in transitional cell carcinoma and lead to therapeutic trials in patients with bladder cancer.
References
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Journal ArticleDOI
A simple quantitative test for cytostatic agents using non-adhering cells in vitro.
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The effects of podophyllin on the maturation and cleavage of the starfish egg.
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Aufnahme von thymidin durch mastocytomzellenin vitro unter der einwirkung von podophyllumstoffen
K. Batz,F. Kalberer,H. Stähelin +2 more
TL;DR: SP-G and SP-I, two podophyllum preparations with spindle poison activity, were tested for their effect on3H-thymidine incorporation into P-815 mastocytoma cellsin vitro and did not affect DNA-synthesis as measured by thymidine incorporate.
Journal Article
On some biological effects of the cytostatic agent verrucarin A
Rüsch Me,Stähelin H +1 more