Journal ArticleDOI
A biologically active analogue of oxytocin not containing a disulfide group.
J. Rudinger,K. Jošt +1 more
TLDR
Die Synthese eines Analogen des Deamino-oxytocins, in dem ein Schwefelatom der Disulfidbrücke durch eine Methylengruppe ersetzt ist (I,X = CH2,R=H), wird beschrieben.Abstract:
Die Synthese eines Analogen des Deamino-oxytocins, in dem ein Schwefelatom der Disulfidbrucke durch eine Methylengruppe ersetzt ist (I,X = CH2,R=H), wird beschrieben. Die Verbindung hat oxytocinahnliche biologische Wirkungen.read more
Citations
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Journal ArticleDOI
Highly active cyclic and bicyclic somatostatin analogues of reduced ring size
D. F. Veber,Frederick W. Holly,Ruth F. Nutt,Susan J. Bergstrand,Stephen F. Brady,Ralph Hisrschmann,Monroe S. Glitzer,Richard Saperstein +7 more
TL;DR: The preparation of conformationally constrained analogues of somatostatin which are highly active inhibitors of the release of insulin, glucagon and growth hormone in vivo are reported.
Journal ArticleDOI
Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor.
Petra Johannesson,Gunnar Lindeberg,Anja Johansson,Gregory V. Nikiforovich,Adolf Gogoll,Barbro Synnergren,Madeleine Le Grèves,F Nyberg,and Anders Karlén,Anders Hallberg +9 more
TL;DR: The cyclic vinyl sulfides that have agonist activity were both shown to possess low-energy conformers compatible with the previously proposed 3D model for the bioactive conformation of Ang II.
Journal ArticleDOI
Diaminodiacid-based solid-phase synthesis of peptide disulfide bond mimics.
Hong-Kui Cui,Ye Guo,Yao He,Feng-Liang Wang,Hao-Nan Chang,Yujia Wang,Fangming Wu,Changlin Tian,Lei Liu +8 more
TL;DR: These disulfide surrogates wereusually synthesized through thiol alkylation, azide–alkynecycloaddition, or olefin metathesis reactions occurring at thepeptide side chains after the peptide skeletons are fullyassembled.
Journal ArticleDOI
Relationship of structure to biological activity of insulin as revealed by degradative studies
Book ChapterDOI
Basic Pharmacological Properties of Synthetic Analogues and Homologues of the Neurohypophysial Hormones
B. Berde,R. A. Boissonnas +1 more
TL;DR: The principal aim of all this work was to try to establish relationships between the chemical structure and the biological activities of these hormones.
References
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Journal ArticleDOI
Automatic recording apparatus for use in the chromatography of amino acids.
Journal ArticleDOI
The synthesis of an octapeptide amide with the hormonal activity of oxytocin
Vincent du Vigneaud,Charlotte Ressler,Carleton W. Roberts,Panayotis G. Katsoyannis,Samuel Gordon +4 more
Journal ArticleDOI
A highly potent analogue of oxytocin, desamino-oxytocin.
TL;DR: The synthesis and biological activities of desamino-oxytocin, an analogue lacking the free amino group present in oxytocin, are described and the presence of an amino group is vital to the possession of pharmacological activity is determined.
Journal Article
The isolation of a protein from the pars neuralis of the ox pituitary with constant oxytocic, pressor and diuresis-inhibiting activities
TL;DR: Experiments designed to demonstrate that the oxytocic and vasopressor activities are moieties chemically united with the protein are described, and reduction of the cystine in the protein by thioglycollic acid nearly abolishes the activity.
Related Papers (5)
Amino acids and peptides. LXIX. Synthesis of two biologically active analogues of deamino-oxytocin not containing a disulphide bond
K. Jošt,J. Rudinger +1 more