Journal ArticleDOI
A case report of propofol dependence in a physician.
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TLDR
The present case shows for the first time that craving for propofol can be quite intense and able to induce addictive behaviour.Abstract:
Propofol is a widely used general anaesthetic with multisite mechanisms and especially ultrashort activation of certain central GABA-A receptors. Since its introduction into the market in the mid 1980s this is the seventh report on propofol dependence in the literature. The present case shows for the first time that craving for propofol can be quite intense and able to induce addictive behaviour.read more
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Journal ArticleDOI
The abuse potential of propofol.
TL;DR: Evidence is found to support propofol's abuse potential from a pharmacological and experiential standpoint with multiple reports describing tolerance, dependence, withdrawal phenomena, abuse, and death from recreational use.
Journal Article
Propofol infusion syndrome and Brugada syndrome electrocardiographic phenocopy.
Andrés Ricardo Pérez Riera,Augusto Hiroshi Uchida,Edgardo Schapachnik,Sergio Dubner,Celso Ferreira Filho,Celso Ferreira +5 more
TL;DR: Propofol is a safe anesthetic agent, but propofol infusion syndrome is a rare lethal complication that offers advantages over traditional anesthetics in clinical situations in which rapid recovery is important.
Journal ArticleDOI
The misuse and abuse of propofol.
TL;DR: The pharmacology and misuse/abuse potential of propofol and the influence of the 12-step recovery paradigm in the re-entry literature are reviewed and existing research and policy are drawn upon to suggest employment re- entry guidelines for healthcare workers.
Journal ArticleDOI
Self-administration of propofol is mediated by dopamine D1 receptors in nucleus accumbens in rats.
Qingquan Lian,Benfu Wang,Wenhua Zhou,Shengwei Jin,L. Xu,Q. Huang,Miaojun Lai,K. Lu,L. Tang,Huaqiang Zhu,H. Lin,Fuqiang Zhang,H. Cao,Jianghui Li,Jing Chen,Ren-Shan Ge,Ren-Shan Ge +16 more
TL;DR: Findings provide the first direct evidence that D1 receptors in nuclear accumbens play an important role in the maintenance of propofol self-administration.
Journal ArticleDOI
Extracellular Signal-Regulated Kinase in Nucleus Accumbens Mediates Propofol Self-Administration in Rats
Benfu Wang,Xiao-wei Yang,Anna Sun,Lanman Xu,Sicong Wang,Wenxuan Lin,Miaojun Lai,Huaqiang Zhu,Wenhua Zhou,Qingquan Lian +9 more
TL;DR: The data suggest that ERK signal transduction pathways coupled with D1 dopamine receptors in the NAc may be involved in the maintenance of propofol self-administration and its rewarding effects.
References
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Journal Article
Benzodiazepine Use, Abuse, and Dependence
TL;DR: Due to the chronic nature of anxiety, long-term low-dose benzodiazepine treatment may be necessary for some patients; this continuation of treatment should not be considered abuse or addiction.
Journal ArticleDOI
Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane
Matthew D. Krasowski,Vladimir V. Koltchine,Caroline E. Rick,Qing Ye,Suzanne E. Finn,Neil L. Harrison +5 more
TL;DR: The effects of propofol, etomidate, the barbiturate methohexital, and the steroid alphaxalone on wild-type and mutant GABAA receptors expressed in human embryonic kidney 293 cells indicate that the receptor structural requirements for positive modulation by volatile and intravenous general anesthetics may be quite distinct.
Journal ArticleDOI
Sertraline treatment of pathological gambling: a pilot study.
Jerónimo Saiz-Ruiz,Carlos Blanco,Angela Ibáñez,Xavier Masramon,Margarita M. Gómez,María Madrigal,T Diez +6 more
TL;DR: Sertraline was not statistically significantly superior to placebo in the overall sample, and the power of the study was limited by the high placebo-response rate and the small sample size.
Journal ArticleDOI
Mapping of chemical trigger zones for reward.
Satoshi Ikemoto,Roy A. Wise +1 more
TL;DR: This approach has identified GABAergic, dopaminergic, glutamatergic, and cholinergic trigger zones within meso-corticolimbic circuitry important for natural reward function.
Journal ArticleDOI
Molecular and systemic mechanisms of general anaesthesia: the 'multi-site and multiple mechanisms' concept.
TL;DR: The finding that amnesia, hypnosis and immobility involve distinct molecular targets opens new avenues for developing improved therapeutic strategies in anaesthesia.