A clinical study shows safety and efficacy of autologous bone marrow mononuclear cell therapy to improve quality of life in muscular dystrophy patients.
Alok Sharma,Hemangi Sane,Prerna Badhe,Nandini Gokulchandran,Pooja Kulkarni,Mamta Lohiya,Hema Biju,V. C. Jacob +7 more
TLDR
Assessment after transplantation showed neurological improvements in trunk muscle strength, limb strength on manual muscle testing, gait improvements, and a favorable shift on assessment scales such as the Functional Independence Measure and the Brooke and Vignos Scales.About:
This article is published in Cell Transplantation.The article was published on 2013-01-01 and is currently open access. It has received 33 citations till now. The article focuses on the topics: Muscular dystrophy & Duchenne muscular dystrophy.read more
Citations
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Duchenne muscular dystrophy: current cell therapies:
Dorota Sienkiewicz,Wojciech Kułak,Bożena Okurowska-Zawada,Grażyna Paszko-Patej,Katarzyna Kawnik +4 more
TL;DR: Current therapeutic methods for Duchenne muscular dystrophy are presented, based on scientific articles in English published mainly in the period 2000 to 2014, using the PubMed database to identify and review the most important studies.
Journal ArticleDOI
Where do we stand in trial readiness for autosomal recessive limb girdle muscular dystrophies
Volker Straub,M. Bertoli +1 more
TL;DR: The current status of determinants of successful drug development programmes for LGMD2 are reviewed, and the challenges of translating promising therapeutic strategies into effective and accessible treatments for patients are reviewed.
Journal ArticleDOI
An update on diagnostic options and considerations in limb-girdle dystrophies.
TL;DR: The review presents an update of the clinical phenotypes and diagnostic options for LGMD including both dominant and recessive LGMD and consider their differential clinical and histopathological features.
Journal ArticleDOI
Clinical neurorestorative cell therapies: Developmental process, current state and future prospective
TL;DR: The developmental process, current state, and future prospective for clinical neurorestorative CT are introduced and the type of cells that yield promising results and restore damaged neurological structure and functions of the central nervous system are explored.
Journal ArticleDOI
Autologous Cord Blood in Children with Cerebral Palsy: A Review
TL;DR: An increasing amount of evidence suggests that CB may be used for both early diagnostics and treatment of cerebral palsy, and several clinical studies confirmed the safety and efficacy of CB administration in both autologous and allogeneic models.
References
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G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
Isabelle Petit,Martine Szyper-Kravitz,Arnon Nagler,Meir Lahav,Amnon Peled,Liliana Habler,Tanya Ponomaryov,Russell S. Taichman,Fernando Arenzana-Seisdedos,Nobutaka Fujii,Judith Sandbank,Dov Zipori,Tsvee Lapidot +12 more
TL;DR: It is suggested that manipulation of SDF-1–CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation.
Book
Mechanism of Action
Paul D. Shaw,David Gottlieb +1 more
TL;DR: Probiotics regulation and formulations are discussed, current understanding of mechanisms of action are reviewed, and recent study data in regards to clinically relevant GI disorders are summarized.
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Performance profiles of the functional independence measure.
TL;DR: Understanding patterns of difficulty in performing FIM items according to types of impairment and levels of function, clinicians may more precisely design treatment programs, use services and predict outcomes of medical rehabilitation.
Journal ArticleDOI
The revision of the Declaration of Helsinki: past, present and future
TL;DR: A review of the past and present versions of the Declaration of Helsinki and some of the possible future trajectories for the Declaration in the light of its history and standing in the world of the ethics of medical research are given.
Journal ArticleDOI
Clinical trial in duchenne dystrophy. I. The design of the protocol
Michael H. Brooke,Robert C. Griggs,Jerry R. Mendell,Gerald M. Fenichel,Jack B. Shumate,Richard J. Pellegrino +5 more
TL;DR: A protocol has been designed which selects patients with Duchenne muscular dystrophy and permits accurate measurement of their status and an integral part of the protocol is a system for checking on the consistency of the data obtained using a computer program.
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