Showing papers in "Cell Transplantation in 2013"

TL;DR: The features of fresh product were retained in the Lipogems product obtained from human cadavers, paving the way to an off-the-shelf strategy for reconstructive procedures and regenerative medicine.

TL;DR: Observations at 1 year indicate that the obtaining, culture, and intraspinal transplantation of autologous olfactory ensheathing cells were safe and feasible and the significance of the neurological improvement in the transplant recipients and the extent to which the cell transplants contributed to it will require larger numbers of patients.

TL;DR: Allogeneic MSCT resulted in the induction of clinical remission and improvement in organ dysfunction in drug-resistant SLE patients, and disease activity declined as revealed by significant changes in the SLEDAI score, levels of serum autoantibodies, albumin, and complements.

TL;DR: This study demonstrates the tolerability, safety, and potential efficacy of ASCs for the treatment of Crohn's fistula and provides support for further clinical study.

TL;DR: The decellularization of porcine livers is described to generate liver constructs at a scale that can be clinically relevant and provides proof-of-principle for the generation of a human-sized, three-dimensional organ scaffold as a potential structure for human liver grafts reconstruction for transplantation to treat liver disease.

TL;DR: A subcutaneous implantable bioartificial pancreas (BAP)—the “β-Air”— is designed that is able to overcome critical challenges in current clinical islet transplantation protocols: adequate oxygen supply to the graft and protection of donor islets against the host immune system.

TL;DR: The data suggest that delayed intranasal administration of stem cells is feasible in the treatment of stroke and hypoxic preconditioning of transplanted cells, significantly enhances cell's homing to the ischemic region, and optimizes the therapeutic efficacy.

TL;DR: The results from this trial support expanded studies of TRC therapy in the treatment of craniofacial deformities, and appear safe and accelerates bone regeneration, enabling jawbone reconstruction with oral implants.

TL;DR: The results indicate that hypoxia microenvironment can enhance cancer cell growth through the paracrine effects of the MSCs by driving their TGF-β1 gene expression and secretion.

TL;DR: Evidence is provided that intra-articular stem cell therapy can prevent the development of Posttraumatic arthritis after fracture and has implications for possible clinical interventions after joint injury before evidence of significant OA.

TL;DR: AD transplantation could modulate microglial activation in AD mice, mitigate AD symptoms, and alleviate cognitive decline, all of which suggest ADSC transplantation as a promising choice for AD therapy.

TL;DR: Biostable, macroporous scaffolds from poly(dimethylsiloxane) (PDMS) are fabricated and investigated islet retention and distribution, metabolic function, and glucose-dependent insulin secretion within these scaffolds and indicate the potential for transplanting islets into a clinically relevant, extrahepatic site that provides spatial distribution of islets as well as intradevice vascularization.

TL;DR: The functionally closed automated cell culture hollow fiber bioreactor Quantum cell expansion system is investigated as an alternative novel tool to conventional tissue flasks for efficient clinical-scale MSC isolation and expansion from bone marrow using PL.

TL;DR: The results indicated that transplantation of a combination of ASCs in HA solution determined a significant improvement in tightening of the skin without complications such as anechoic areas, fat necrosis, or infections, thus suggesting that ASCs are a potentially valuable source of cells for skin therapy in rare diseases such as SSc and generally in skin disorders.

TL;DR: The results further highlight the potential for using macroencapsulation to avoid immunosuppressive therapy in clinical islet transplantation and suggest that the TheraCyte™ device protects islet allografts also in immunized recipients.

TL;DR: Adipose-derived stem cells (ADSCs) are abundant in WAT and BAT, have multipotent characteristics, and are easily extracted, therefore, ADSC could be considered as a strategy for future regenerative medicine and tissue engineering.

TL;DR: It is demonstrated that promoting migration of MSCs could increase their therapeutic potential and indicates a new therapeutic paradigm for organ repair.

TL;DR: A comparative investigation demonstrates that transplanted Ad-MSCs play a significant role in tissue repair processes by virtue of their ability to suppress inflammation coupled with their enhanced ability to home to the injured CNS.

TL;DR: BM-MSCs from diabetic and nondiabetic human subjects could be differentiated without genetic manipulation to form IPCs that, when transplanted, could maintain euglycemia in diabetic mice for 3 months and optimization of the culture conditions are required to improve the yield and their functional performance.

TL;DR: Intra-artery delivery of UCMSCs via catheterization was a feasible and safe approach and may improve the neurological function of ischemic stroke patients with the middle cerebral artery territory infarcts.

TL;DR: It is suggested that CTX0E03 cell therapy may provide significant benefit to stroke patients through upregulation of angiogenesis in the ischemic brain through both release of paracrine factors and direct physical interaction.

TL;DR: The combination of conventional surgery, chemotherapy, and radiotherapy with stem cell-orientated therapy may provide a new promising treatment for reducing GBM recurrence and improving the survival rate.

TL;DR: It is demonstrated that hMAPCs are nonimmunogenic for T-cell proliferation and cytokine production and can serve as a valuable cell source for the clinical use of immunomodulatory cellular stem cell product.

TL;DR: Evidence is provided that exposure of human skin fibroblasts to a Radio Electric Asymmetric Conveyer (REAC), an innovative device delivering radio electric conveyed fields at a radiofrequency of 2.4 GHz, afforded remarkable commitment toward cardiac, neuronal, and skeletal muscle lineages.

TL;DR: PDA001 cells may provide a viable cell source to treat stroke and be related to the increase of VEGF, HGF, and BDNF expression, and a decrease of apoptosis.

TL;DR: Cell therapy presents a favorable safety profile with a low adverse event rate and no increase in severe events such as mortality and cancer and treatment with cell therapy decreases the risk of amputation, and has a positive benefit-to-risk ratio in CLI.

TL;DR: BMI, pancreas size, and CIT are useful variables for predicting islet yield, but selection of enzyme and balancing digestion time and rate are also important.

TL;DR: Animal MRI results indicated that the majority of contralaterally transplanted iPSC-derived NPCs migrated to the peri-infarct area, showing a pathotropism critical for tissue recovery.

TL;DR: Evidence is presented that donor ASCs and acceptor Tregs do not impair each other's function and therefore encourages the use of MSC therapy for the prevention of graft rejection in solid organ transplantation.

TL;DR: Novel evidence is provided that BMSC transplantation has the potential to repair the ischemia-damaged neural networks and restore lost neuronal connections and the recovered circuit activity likely contributes to the improved sensorimotor function after focal ischemic stroke and BSC transplantation.