A database of Caenorhabditis elegans behavioral phenotypes
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Using low-cost automated tracking microscopes, a behavioral database for 305 Caenorhabditis elegans strains, including 76 mutants with no previously described phenotype are generated, so that phenotypes can be identified and understood by users.Abstract:
Using low-cost automated tracking microscopes, we have generated a behavioral database for 305 Caenorhabditis elegans strains, including 76 mutants with no previously described phenotype. The growing database currently consists of 9,203 short videos segmented to extract behavior and morphology features, and these videos and feature data are available online for further analysis. The database also includes summary statistics for 702 measures with statistical comparisons to wild-type controls so that phenotypes can be identified and understood by users.read more
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Optogenetic analyses of neuronal network function and synaptic transmission in Caenorhabditis elegans
TL;DR: The transparent nematode Caenorhabditis elegans, with its anatomically well-defined nervous system comprising 302 neurons that regulate quantifiable behaviors, is an ideal model system for the development and application of optogenetic methods.
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Recurrent Neural Networks with Interpretable Cells Predict and Classify Worm Behaviour
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Deep behavioural phenotyping reveals divergent trajectories of ageing and quantifies health state in C. elegans
Celine N. Martineau,Celine N. Martineau,Baskaner B,Renée I. Seinstra,William R Schafer,Brown Aex,Nollen Eaa,Patrick Laurent +7 more
TL;DR: The power of multi-parametric dataset to describe ageing, to quantify health and to predict specific health risks is demonstrated and the pathological progression in individual animals can be predicted from early phenotypes with high accuracy.
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Multi-environment phenotyping of C. elegans for robust evaluation of physical performance
Jennifer E. Hewitt,Jennifer E. Hewitt,Ricardo Laranjeiro,Masoud Norouzi,Rebecca Ellwood,Adam Antebi,Nathaniel J. Szewczyk,Monica Driscoll,Siva A. Vanapalli +8 more
TL;DR: The ability to robustly define C. elegans locomotory phenotypes demonstrates the utility of the MEP approach toward identification of candidates for therapeutic intervention, especially in disease models in which the neuromuscular performance is impaired.
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Transcriptional variation and divergence of host-finding behaviour in Steinernema carpocapsae infective juveniles
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References
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TL;DR: In this paper, the authors describe methods for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm.
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The structure of the nervous system of the nematode Caenorhabditis elegans
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A direct approach to false discovery rates
TL;DR: The calculation of the q‐value is discussed, the pFDR analogue of the p‐value, which eliminates the need to set the error rate beforehand as is traditionally done, and can yield an increase of over eight times in power compared with the Benjamini–Hochberg FDR method.
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