scispace - formally typeset
Open AccessJournal ArticleDOI

A database of Caenorhabditis elegans behavioral phenotypes

Reads0
Chats0
TLDR
Using low-cost automated tracking microscopes, a behavioral database for 305 Caenorhabditis elegans strains, including 76 mutants with no previously described phenotype are generated, so that phenotypes can be identified and understood by users.
Abstract
Using low-cost automated tracking microscopes, we have generated a behavioral database for 305 Caenorhabditis elegans strains, including 76 mutants with no previously described phenotype. The growing database currently consists of 9,203 short videos segmented to extract behavior and morphology features, and these videos and feature data are available online for further analysis. The database also includes summary statistics for 702 measures with statistical comparisons to wild-type controls so that phenotypes can be identified and understood by users.

read more

Citations
More filters
Book ChapterDOI

The Contract Random Interval Spectral Ensemble (c-RISE): The Effect of Contracting a Classifier on Accuracy

TL;DR: It is shown how the dynamic approach to contracting is more effective than the static approach of estimating the complexity before executing, and the effect of contracting on accuracy for a range of large problems is investigated.
Journal ArticleDOI

Establishment and maintenance of motor neuron identity via temporal modularity in terminal selector function

TL;DR: It is found that the suite of UNC-3 targets in MNs is modified across different life stages, revealing ‘temporal modularity’ in terminal selector function.
Journal ArticleDOI

Permutation entropy: Influence of amplitude information on time series classification performance.

TL;DR: The present study quantifies the performance of the standard PE method and other amplitude–included PE methods using a disparity of time series to find out if there are really significant performance differences, and compares statistics based uniquely on ordinal or amplitude patterns.
Journal ArticleDOI

Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans

TL;DR: It is found that neuronal xbp-1s modulates feeding behavior and reproduction, dependent upon tyramine synthesis, and remodels neuronal signaling to coordinately modulate intestinal physiology and stress-responsive behavior, functioning as a global regulator of organismal responses to stress.
Journal ArticleDOI

In actio optophysiological analyses reveal functional diversification of dopaminergic neurons in the nematode C. elegans.

TL;DR: Functional divergence is demonstrated in the genetically similar dopaminergic neurons of C. elegans, which may provide a new entry point toward understanding functional diversity of neurons beyond genetic terminal identification.
References
More filters
Journal ArticleDOI

The genetics of caenorhabditis elegans

TL;DR: In this paper, the authors describe methods for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm.
Journal ArticleDOI

The structure of the nervous system of the nematode Caenorhabditis elegans

TL;DR: The structure and connectivity of the nervous system of the nematode Caenorhabditis elegans has been deduced from reconstructions of electron micrographs of serial sections as discussed by the authors.
Journal ArticleDOI

A direct approach to false discovery rates

TL;DR: The calculation of the q‐value is discussed, the pFDR analogue of the p‐value, which eliminates the need to set the error rate beforehand as is traditionally done, and can yield an increase of over eight times in power compared with the Benjamini–Hochberg FDR method.

“Bioinformatics” 특집을 내면서

TL;DR: Assessment of medical technology in the context of commercialization with Bioentrepreneur course, which addresses many issues unique to biomedical products.
Related Papers (5)