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A database of Caenorhabditis elegans behavioral phenotypes

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TLDR
Using low-cost automated tracking microscopes, a behavioral database for 305 Caenorhabditis elegans strains, including 76 mutants with no previously described phenotype are generated, so that phenotypes can be identified and understood by users.
Abstract
Using low-cost automated tracking microscopes, we have generated a behavioral database for 305 Caenorhabditis elegans strains, including 76 mutants with no previously described phenotype. The growing database currently consists of 9,203 short videos segmented to extract behavior and morphology features, and these videos and feature data are available online for further analysis. The database also includes summary statistics for 702 measures with statistical comparisons to wild-type controls so that phenotypes can be identified and understood by users.

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Automated scoring of nematode nictation on a textured background

TL;DR: In this paper , a Mask R-CNN-based tracker is used to segment Caenorhabditis elegans dauers and S. carpocapsae infective juveniles.
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Temporal transitions in post-mitotic neurons throughout the C. elegans nervous system

TL;DR: This work comprehensively characterized the distinct functional states (locomotor behavior) and corresponding distinct molecular states (transcriptome) of the post-mitotic nervous system across temporal transitions from early post-embryonic periods to adulthood and found that nlp-45 is required for temporal transitions in exploratory activity across larval stages, across sexual maturation, and into a diapause arrest stage.
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Motion Prediction Enables Simulated MR-imaging of Freely Moving Model Organisms

TL;DR: It is shown that adjustment of the scanning to the predicted movements strongly reduces distortions in the resulting image, opening the door for implementation in a high-resolution NMR scanner.
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A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior.

TL;DR: In this paper, the authors show that the Caenorhabditis elegans NLP-12 neuropeptide system shapes responses to food availability by modulating the activity of head and body wall motor neurons through alternate G-protein coupled receptor (GPCR) targets, CKR-1 and CKR2.
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Emergent complexity in slowly driven stochastic processes

A. Costa, +1 more
- 27 Jan 2023 - 
TL;DR: In this article , the distribution of first passage time events in the presence of non-ergodic modes that drive ergodic dynamics on a potential landscape is considered, and it is shown that in the limit of slow and large enough fluctuations the distribution exhibits heavy tails dominated by a power law with exponent f(t) ~ t−2, and corrections depend on the strength and the nature of fluctuations.
References
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Journal ArticleDOI

The genetics of caenorhabditis elegans

TL;DR: In this paper, the authors describe methods for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm.
Journal ArticleDOI

The structure of the nervous system of the nematode Caenorhabditis elegans

TL;DR: The structure and connectivity of the nervous system of the nematode Caenorhabditis elegans has been deduced from reconstructions of electron micrographs of serial sections as discussed by the authors.
Journal ArticleDOI

A direct approach to false discovery rates

TL;DR: The calculation of the q‐value is discussed, the pFDR analogue of the p‐value, which eliminates the need to set the error rate beforehand as is traditionally done, and can yield an increase of over eight times in power compared with the Benjamini–Hochberg FDR method.

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