Journal ArticleDOI
A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition
Roberto Romero,Ricardo Gomez,Fabio Ghezzi,Bo Hyun Yoon,Moshe Mazor,Samuel S. Edwin,Stanley M. Berry +6 more
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TLDR
In this article, the authors proposed that preterm labor in the setting of infection results from the actions of proinflammatory cytokines secreted as part of the fetal and/or maternal host response to microbial invasion.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 1998-07-01. It has received 514 citations till now. The article focuses on the topics: Premature rupture of membranes & Amniotic fluid.read more
Citations
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Epidemiology and causes of preterm birth
TL;DR: A short cervical length and a raised cervical-vaginal fetal fibronectin concentration are the strongest predictors of spontaneous preterm birth.
Journal ArticleDOI
Intrauterine infection and preterm delivery.
TL;DR: Preterm delivery is the chief problem in obstetrics today, accounting for 70 percent of perinatal mortality and nearly half of long-term neurologic morbidity, and the remainder follow the spontaneous onset of labor or rupture.
Journal ArticleDOI
The preterm parturition syndrome
Roberto Romero,Jimmy Espinoza,Juan Pedro Kusanovic,Francesca Gotsch,Sonia S. Hassan,Offer Erez,Tinnakorn Chaiworapongsa,Moshe Mazor +7 more
TL;DR: The evidence indicating that the pathological processes implicated in the preterm parturition syndrome include: intrauterine infection/inflammation; uterine ischaemia; (3) uterine overdistension; (4) abnormal allograft reaction; (5) allergy; (6) cervical insufficiency; and (7) hormonal disorders (progesterone related and corticotrophin‐releasing factor related).
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The fetal inflammatory response syndrome.
TL;DR: The fetal systemic inflammatory response as a mechanism of disease is reviewed and potential interventions to control an exaggerated inflammatory response in utero are also described.
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The epidemiology of cerebral palsy: Incidence, impairments and risk factors
TL;DR: The majority of people with CP have the spastic syndrome of which the diplegic group is the smallest, and the most important risk factors for CP are low birthweight, intrauterine infections and multiple gestation.
References
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Matrix metalloproteinases and their inhibitors in connective tissue remodeling.
TL;DR: Latency is overcome by physical, chemical, and enzymatic treatments that separate the cysteine residue from the zinc Expression of the metalloproteinases is switched on by a variety of agents acting through regulatory elements of the gene, particularly the AP‐1 binding site.
Journal ArticleDOI
The fetal inflammatory response syndrome.
TL;DR: The fetal systemic inflammatory response as a mechanism of disease is reviewed and potential interventions to control an exaggerated inflammatory response in utero are also described.
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Infection and labor. VIII. Microbial invasion of the amniotic cavity in patients with suspected cervical incompetence: prevalence and clinical significance.
Roberto Romero,Roberto Romero,Rogelio Gonzalez,Rogelio Gonzalez,Waldo Sepulveda,Waldo Sepulveda,Francisco Brandt,Francisco Brandt,Marcelo Ramirez,Marcelo Ramirez,Yoram Sorokin,Yoram Sorokin,Moshe Mazor,Moshe Mazor,Marjorie C. Treadwell,Marjorie C. Treadwell,David B. Cotton,David B. Cotton +17 more
TL;DR: Amniocentesis to determine the microbiologic characteristics of the amniotic cavity should be considered before a cerclage is placed in women presenting with cervical dilatation in the midtrimester of pregnancy.
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Infection and labor. IV. Cachectin-tumor necrosis factor in the amniotic fluid of women with intraamniotic infection and preterm labor.
Roberto Romero,Kirk R. Manogue,Murray D. Mitchell,Ying King Wu,E. Oyarzun,John C. Hobbins,Anthony Cerami +6 more
TL;DR: The data support the concept that macrophage activation is involved in the onset of human parturition in the setting of infection, and it is proposed that the host (fetus and/or mother) signalsThe onset of parturitions through the secretion of inflammatory cytokines released in response to bacterial invasion.
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The Preterm Labor Syndrome
TL;DR: The evidence is reviewed that preterm labor is a pathologic condition caused by multiple etiologies, and hence should be considered a syndrome: the Preterm Labor Syndrome.