Journal ArticleDOI
A gene complex controlling segmentation in Drosophila.
TLDR
The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.Abstract:
The bithorax gene complex in Drosophila contains a minimum of eight genes that seem to code for substances controlling levels of thoracic and abdominal development. The state of repression of at least four of these genes is controlled by cis-regulatory elements and a separate locus (Polycomb) seems to code for a repressor of the complex. The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.read more
Citations
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Journal ArticleDOI
Mutations affecting segment number and polarity in Drosophila
TL;DR: The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.
Journal Article
Preservation of duplicate genes by complementary, degenerative mutations.
TL;DR: Cooke et al. as mentioned in this paper proposed a new conceptual framework for understanding the evolution of duplicate genes that may help explain this conundrum, focusing on the regulatory complexity of eukaryotic genes, and showed how complementary degenerative mutations in different regulatory elements of duplicated genes can facilitate the preservation of both duplicates, thereby increasing long-term opportunities for the development of new gene functions.
Journal ArticleDOI
Preservation of Duplicate Genes by Complementary, Degenerative Mutations
TL;DR: Focusing on the regulatory complexity of eukaryotic genes, it is shown how complementary degenerative mutations in different regulatory elements of duplicated genes can facilitate the preservation of both duplicates, thereby increasing long-term opportunities for the evolution of new gene functions.
Journal ArticleDOI
Specification of cerebral cortical areas
TL;DR: The radial unit model provides a framework for understanding cerebral evolution, epigenetic regulation of the parcellation of cytoarchitectonic areas, and insight into the pathogenesis of certain cortical disorders in humans.
Journal ArticleDOI
The Polycomb complex PRC2 and its mark in life
Raphaël Margueron,Danny Reinberg +1 more
TL;DR: This work has uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes, and expanded the perspectives on its function and regulation.
References
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Journal ArticleDOI
Developmental compartmentalisation of the wing disk of Drosophila.
TL;DR: This report will demonstrate the existence of clonal segregation of developmental pathways in the wing (dorsal mesothoracic) disk of Drosophila and show that these cell lineages are fixed.
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Lakes Beneath the Antarctic Ice Sheet
TL;DR: The technique of radio-echo sounding of polar ice sheets is now well established as mentioned in this paper, and three seasons of radioecho sounding from long range aircraft of the US Navy have been completed under a joint programme of the Scott Polar Research Institute and the US National Science Foundation.
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Genes and Developmental Pathways
TL;DR: An approach is discussed which makes use of a series of pseudoallelic genes in Drosophila which have, in several instances, been profitably exploited in the bacteria to learn more about how genes control biochemical pathways.
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Pseudoallelism and gene evolution.
TL;DR: The underlying thesis will be that in those instances of pseudoallelism in which there is evidence for close functional similarity among the component genes the authors may come close to seeing the direct results of a process which produces new genes.