A green process for the preparation of 11-{4-[2-(2-hydroxyethoxy) ethyl]-1-piperazinyl}dibenzo[b,f][1,4]thiazepine
Ganesh Devidas Mahale,Ashok Kumar,Dharmendra Singh,Arumugamangalam V. Ramaswamy,Suresh B. Waghmode +4 more
TLDR
In this article, a green process for the synthesis of 11-{4]-2-(2-hydroxyethoxy)ethyl]- 1-piperazinyl}dibenzo[b,f][1,4]thiazepine by the reaction of 11-(1-pariazinyl) dibenzyncyclohexane or its dihydrochloride salt with 2-chloroethoxy ethanol in the presence of an inorganic base and water is reported (conversion 99.9 % in a short time and without any impurities).Abstract:
A green process for the synthesis of 11-{4-[2-(2-hydroxyethoxy)ethyl]- 1-piperazinyl}dibenzo[b,f][1,4]thiazepine by the reaction of 11-(1-piperazinyl) dibenzo[b,f][1,4]thiazepine or its dihydrochloride salt with 2-(2-chloroethoxy) ethanol in the presence of an inorganic base and water is reported (conversion 99.9 % in a short time and without any impurities). The metal halides and phase transfer catalyst increase the rate of reaction, especially in water as the solvent.read more
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Synthesis and Characterization of Thiazepine/Benzothiazepine Derivatives Through Intramolecular C‐2 Ring Expansion Pathway
Simer Preet,Damanjt Singh Cannoo +1 more
TL;DR: A facile and highly efficient one-pot synthesis of novel thiazepine and benzothiazepine derivatives was established by ring expansion by using a greener methodology and the synthesized compounds show fluorescence and also antioxidant activity.
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Direct N-alkylation of sulfur-containing amines.
TL;DR: An efficient ruthenium-catalyzed method has been developed for the direct N-alkylation of sulfur-containing amines with alcohols, for the first time, by a step-economical and environmentally friendly hydrogen borrowing strategy as discussed by the authors.
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Dibenzothiazepine a break through heterocyclic nucleus in medicinal chemistry
TL;DR: In this paper, the authors focused on pharmacological and synthetic profile of dibenzothiazepine, a conjugated heterocyclic ring systems reported for their wide spectrum of pharmacological activity especially for its psychotherapeutic activities.
References
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Journal ArticleDOI
Behavioral approach to nondyskinetic dopamine antagonists: identification of seroquel.
Edward John Warawa,Bernard Martin Migler,Cyrus John Ohnmacht,Ann L. Needles,George C. Gatos,Mclaren Frances Marie,Cynthia L. Nelson,Karen M. Kirkland +7 more
TL;DR: Dyskinetic clozapine is a low-potency D2 dopamine receptor antagonist which appears to act selectively in the mesolimbic area and initial examination of a few close cogeners of 1 enhanced confidence in the Cebus model as a predictor of dyskinetic potential.