Journal ArticleDOI
A longitudinal study to explain the pain-depression link in older adults with osteoarthritis.
Gillian A. Hawker,Monique A. M. Gignac,Elizabeth M. Badley,Aileen M. Davis,M.R. French,Ye Li,Anthony V. Perruccio,J. Denise Power,Joanna E. M. Sale,Wendy Lou +9 more
TLDR
To evaluate whether osteoarthritis (OA) pain determines depressed mood, taking into consideration fatigue and disability and controlling for other factors is evaluated.Abstract:
Objective
To evaluate whether osteoarthritis (OA) pain determines depressed mood, taking into consideration fatigue and disability and controlling for other factors.
Methods
In a community cohort with hip/knee OA, telephone interviews assessed OA pain and disability (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]), fatigue (Multidimensional Fatigue Symptom Inventory), depressed mood (Center for Epidemiologic Studies Depression Scale), and covariates (demographics, self-rated health, comorbidity, pain coping, pain catastrophizing, and social support) at 3 time points over 2 years. Drawing on previous research, a path model was developed to test the interrelationships among the key concepts (pain, depression, fatigue, disability) over time, controlling for covariates.
Results
The baseline mean age was 75.4 years; 78.5% of the subjects were women, 37.2% were living alone, and 15.5% had ≥3 comorbid conditions. WOMAC scores indicated moderate OA symptoms and disability. From the final model with 529 subjects, adjusting for covariates, we found that current OA pain strongly predicted future fatigue and disability (both short and long term), that fatigue and disability in turn predicted future depressed mood, that depressed mood and fatigue were interrelated such that depressed mood exacerbated fatigue and vice versa, and that fatigue and disability, but not depressed mood, led to worsening of OA pain.
Conclusion
Controlling for other factors, OA pain determined subsequent depressed mood through its effect on fatigue and disability. These effects led to worsening of pain and disability over time. These results support the need for improved pain management in OA to prevent or attenuate the downstream effects of pain on disability and mood.read more
Citations
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Journal ArticleDOI
The epidemiology and impact of pain in osteoarthritis.
TL;DR: More insights are needed into pain mechanisms in OA to enable rational mechanism-based management of pain and to contribute to a substantial socioeconomic burden.
Journal ArticleDOI
Persistent pain after joint replacement: Prevalence, sensory qualities, and postoperative determinants
TL;DR: It is found that persistent postsurgical pain is common after joint replacement, although much of the pain is mild, infrequent, or an improvement on preoperative pain.
Journal ArticleDOI
Pain, catastrophizing, and depression in the rheumatic diseases
Robert R. Edwards,Christine M. Cahalan,George Mensing,Michael T. Smith,Jennifer A. Haythornthwaite +4 more
TL;DR: This Review describes the growing body of literature relating depression and catastrophizing to the experience of pain and pain-related sequelae across a number of rheumatic diseases.
Journal ArticleDOI
Reciprocal Relationship between Pain and Depression: A 12-Month Longitudinal Analysis in Primary Care
Kurt Kroenke,Kurt Kroenke,Jingwei Wu,Matthew J. Bair,Matthew J. Bair,Erin E. Krebs,Erin E. Krebs,Teresa M. Damush,Wanzhu Tu,Wanzhu Tu,Wanzhu Tu +10 more
TL;DR: It is shown that pain and depression have strong and similar effects on one another when assessed longitudinally over 12 months, and a change in severity of either symptom predicts subsequent severity of the other symptom.
Journal ArticleDOI
OARSI-FDA initiative: Defining the disease state of osteoarthritis
Nancy E Lane,Kenneth D. Brandt,Gillian A. Hawker,E. Peeva,E. Schreyer,W. Tsuji,Marc C. Hochberg +6 more
TL;DR: The design and conduct of clinical trials for new OA treatments should address the heterogeneity of the disease, treatment-associated structural changes in target joints and patient-reported outcomes.
References
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Journal ArticleDOI
Cutoff criteria for fit indexes in covariance structure analysis : Conventional criteria versus new alternatives
Li-tze Hu,Peter M. Bentler +1 more
TL;DR: In this article, the adequacy of the conventional cutoff criteria and several new alternatives for various fit indexes used to evaluate model fit in practice were examined, and the results suggest that, for the ML method, a cutoff value close to.95 for TLI, BL89, CFI, RNI, and G...
Journal ArticleDOI
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
TL;DR: The CES-D scale as discussed by the authors is a short self-report scale designed to measure depressive symptomatology in the general population, which has been used in household interview surveys and in psychiatric settings.
Book
The global burden of disease: a comprehensive assessment of mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020.
TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
Journal Article
Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.
TL;DR: WOMAC is a disease-specific purpose built high performance instrument for evaluative research in osteoarthritis clinical trials and fulfil conventional criteria for face, content and construct validity, reliability, responsiveness and relative efficiency.
Journal ArticleDOI
The Pain Catastrophizing Scale: Development and validation.
TL;DR: In this paper, the Pain Catastrophizing Scale (PCS) was administered to 425 undergraduates and a three component solution comprising (a) rumination, (b) magnification, and (c) helplessness.
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