Journal ArticleDOI
A model for intracellular energy transport.
G. W. Mainwood,K. Rakusan +1 more
TLDR
A viable alternative to the traditional Krogh model is presented which takes into account the inhomogeneity of the diffusion pathway as a result of mitochondrial clustering.Abstract:
A model for oxygen transfer to cells from capillaries is considered in which mitochondria are either clustered at the cell periphery around capillaries or homogeneously distributed through the cytosol. The capillary required to supply cells utilizing oxygen at the same rate is much less when mitochondria cluster around capillaries. Two alternative mechanisms are considered for distributing energy from peripheral mitochondria to the rest of the cell; i.e., diffusion of ATP or creatine phosphate with enough creatine kinase to ensure equilibrium between the ~P carriers. The latter has clear advantages and would appear to be adequate to supply a fairly large mitochondria-free cell core (e.g., 24-μm diameter) with very little change in ADP levels or in the free energy of ATP hydrolysis at maximum work rates. Thus, a viable alternative to the traditional Krogh model is presented which takes into account the inhomogeneity of the diffusion pathway as a result of mitochondrial clustering.read more
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Direct observation of radial intracellular gradients in a single cardiomyocyte of the rat
TL;DR: In this paper, the authors visualize radial gradients of intracellular P O 2 in a single individual cardiomyocyte isolated from the rat ventricle using microspectrophotometry with the use of cytosolic myoglobin.
Journal ArticleDOI
Diffusion distances, total capillary length and mitochondrial volume in pressure-overload myocardial hypertrophy.
Susan R Kayar,Harvey R. Weiss +1 more
TL;DR: Analysis of the distribution of mitochondria suggested that the new mitochondrial material was added to the center of myofibers, thereby further lengthening oxygen diffusion distances, and there was no evidence that the decreased performance of paced 1K1C hearts was attributable to an oxygen diffusion limitation to mitochondria.
Journal ArticleDOI
Horseshoe crab sperm contain a unique isoform of arginine kinase that is present in midpiece and flagellum
S. J. Strong,W. R. Ellington +1 more
TL;DR: Spermatozoa of the horseshoe crab, Limulus polyphemus, contained high activities of arginine kinase (AK), the bulk of which was completely solubilized in buffer lacking detergent, appearing to play a role in high energy phosphate transport to dynein ATPases in the flagellum.
Journal ArticleDOI
The effect of concurrent endurance and strength training on quantitative estimates of subsarcolemmal and intermyofibrillar mitochondria
TL;DR: It is concluded that IMF mitochondria increase in a linear manner throughout training, while SS mitochondria undergo a preferential increase late in training, which may be related to an increase in proportion of type I fibers.
Journal ArticleDOI
Mitochondrial distribution in relation to changes in muscle metabolism in rat soleus.
TL;DR: The distribution of mitochondria was significantly different in weekly-run versus endurance-trained animals which may reflect differences in substrate source or high-energy phosphate flux in these fibers.
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