Journal ArticleDOI
A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo).
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TLDR
A new muscle damaging toxin, myotoxin II, was purified from the venom of Bothrops asper by ion-exchange chromatography on CM-Sephadex C-25, and immunochemical tests indicate a high degree of homology between this toxin and a previously characterizedMyotoxin I.About:
This article is published in Toxicon.The article was published on 1989-01-01. It has received 213 citations till now. The article focuses on the topics: Myotoxin & Snake venom.read more
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Journal ArticleDOI
Phospholipase A2 myotoxins from Bothrops snake venoms
TL;DR: Current evidence suggests that these toxins interact with biological membranes via a molecular region distinct from their known catalytic site, which may lead to membrane destabilization and loss of selective permeability to ions such as calcium, both of which appear to be important mediators in the process of muscle necrosis.
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Phospholipase A2--a structural review.
Raghuvir K. Arni,Richard J. Ward +1 more
TL;DR: The salient structural features of the class I, II and III PLA2 are discussed with respect to their functional roles and the structural bases of other aspects of PLA2 function are still under debate.
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An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action.
TL;DR: It is proposed that all the toxic activities of Lys49 PLA2s are related to their ability to destabilize natural and artificial membranes, using a cationic/hydrophobic effector site located at their C-terminal loop.
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Host response to Bothrops asper snake venom. Analysis of edema formation, inflammatory cells, and cytokine release in a mouse model.
TL;DR: The present observations suggest that venom, besides its cytotoxic properties, induces early hematologic and immunologic alterations that may be of relevance in future treatment modalities.
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Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action
TL;DR: This work discusses how snake toxins achieve a similar cellular lesion, which is evolutionarily highly conserved, despite the differences listed above, with respect to venom PLA2s.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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A relation between non-esterified fatty acids in plasma and the metabolism of glucose
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Disk Electrophoresis of Basic Proteins and Peptides on Polyacrylamide Gels
TL;DR: DISK electrophoresis on small columns of polyacrylamide gels, a new method for the separation of serum proteins, has been developed by Ornstein and Davis1,2.
Book
Monoclonal Antibodies: Principles and Practice
TL;DR: The present volume has been comprehensively updated to cover recent rapid advances, particularly with respect to the applications of molecular biology, the use of antibodies in closing and heterologous expression of genes, immunohistology and phage display libraries.